Dr. Pedro M. Fernández Salguero

Doctor en Bioquímicas y Biología molecular por la UEx. Licenciado en Ciencias (Sección de Biológicas)

Miembro desde 2017.

CV resumido

I got my masters degree in science (M.S.) and my Ph.D. in Biochemistry and Molecular Biology at the University of Extremadura (UEx) in 1991. I did my postdoctoral tenure at the National Cancer Institute (NCI), NIH, USA between Dec 1991 and Feb 1997. During this period,I was responsible for 3 research projects: (1) Generation of murine knockout models for cancer-related nuclear receptors; (2) Characterization of mutations in the DPYD gene causing lethal toxicity to 5-FU-treated patients; (3) Identification of P450 genes relevant to tobacco-related lung cancer. I am co-inventor of 3 patents on DPYD that produced a licensed diagnostic kit awarded by the USA national technology transfer award (FLC). I returned to the UEx in 1997 as associate professor for Biochemistry and Molecular Biology to be promoted to full professor in 2010. I established the brand-new research group Molecular Biology of Cancer at the University of Extremadura incorporating novel research lines and methodologies and constituting a motivated and successful team of investigators in our context. At that time, I also participate in setting the Biomedicine technical unit of the central services of the University. In addition to research, I also teach "Regulation of cell signaling" and “Mammalian transgenesis" to students of the Biology degree and Biotechnology master, respectively. I have established a catalogued laboratory on Molecular Biology of Cancer regularly funded by competitive projects of the Spanish Government, Red Temática de Investigación Cooperativa en Cáncer-RTICC, Junta de Extremadura and the UEx. I have published 114 scientific papers in peer review journals (JCR) that have received over 11.700 citations. I have a Hirsch index of 50 (Scopus). My laboratory is interested in understanding the role of nuclear receptors in cancer progression and metastasis, particularly in melanoma, glioblastoma and, more recently, hepatocellular carcinoma. We also investigate the role of repetitive elements in the functioning of tumoral cells with emphasis in normal and tumor cell differentiation and pluripotency. The functional interaction of these processes with senescence and tissue regeneration is also a major scientific interest of the group. We use Genetics, Molecular and Cellular Biology and omics methodologies in cellular models, transgenic animal and human tumor biopsies. A major effort is dedicated to collaborate with the Molecular Pathology and Liver transplant Units of the Medical Hospital. We believe that our research is relevant not only to acquire knowledge about the mechanisms driving tumorigenesis and metastatic dissemination but also to human health and to cancer diagnosis and therapy

Áreas de investigación

Papel del receptor de dioxina (AhR) en la progresión y la metástasis tumoral
Mecanismos moleculares de diferenciación y pluripotencia

Publicaciones destacadas

González-Rico FJ, Vicente-García C, Fernández A, Muñoz-Santos D, Montoliu L, Morales-Hernández A, Merino JM, Roman AC, Fernández-Salguero PM . Alu retrotransposons modulate Nanog expression through dynamic changes in regional chromatin. Epigenetics and Chromatin 13:15, 1-13, 2020.
Roman ÁC, Carvajal-Gonzalez JM, Merino JM, Mulero-Navarro S, Fernández-Salguero PM . The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value. Pharmacology & Therapeutics 185, 50-63, 2018.
Morales-Hernández A, Nacarino-Palma A, Moreno-Marín N, Barrasa E, Paniagua-Quiñones B, Catalina-Fernández I, Álvarez-Barrientos A, Bustelo XR, Merino JM, Fernández-Salguero PM . Lung regeneration after toxic injury is improved in absence of dioxin receptor. Stem Cell Research 25, 61-71, 2017.
Moreno-Marín N; Barrasa E; Morales-Hernández A; Paniagua B; Blanco-Fernández G; Merino JM; Fernández-Salguero P . Dioxin receptor adjusts liver regeneration after acute toxic injury and protects against liver carcinogénesis. Scientific Reports 7:10420, 1-12, 2017.
Morales-Hernández A; González-Rico FJ; Román AC; Rico-Leo E; Álvarez-Barrientos A; Sánchez L; Macia A; Heras SR; García-Pérez JL; Merino JM; Fernández-Salguero PM . Alu retrotransposons promote differentiation of human carcinoma cells through the aryl hydrocarbon receptor. Nucleic Acid Research 44, 4665-4683, 2016.


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