Prevalence by health areas of chronic kidney disease in the diabetic population of Extremadura in 2012, 2013 and 2014. An observational study.
Referencia: Fernández-Fernández L, Goujat-Salas J, Ceballos-Malagón C, Tejero-Mas M, Pérez-Caballero FL, Buitrago-Ramírez F. Prevalence by health areas of chronic kidney disease in the diabetic population of Extremadura in 2012, 2013 and 2014. An observational study. Nefrologia (Engl Ed). 2023 Feb 27:S2013-2514(23)00039-1.
Consensus document on asthma and smoking of the Regional Asthma Forum of SEPAR.
Referencia: Álvarez-Gutiérrez FJ, Blanco-Aparicio M, Signes-Costa J, Pastor-Esplá E, García-Rivero JL, Soto Campos JG, Callejas-González FJ, Romero-Palacios PJ, Riesco-Miranda JA, Jiménez-Ruiz CA. Consensus document on asthma and smoking of the Regional Asthma Forum of SEPAR. Adicciones. 2023 Jan 1;35(1):67-84.
Obstructive sleep apnoea is related to melanoma aggressiveness through paraspeckle protein-1 upregulation.
Referencia: Cubillos-Zapata C, Martínez-García MÁ, Díaz-García E, García-Tovar S, Campos-Rodríguez F, Sánchez-de-la-Torre M, Nagore E, Martorell-Calatayud A, Blasco LH, Pastor E, Abad-Capa J, Montserrat JM, Cabriada-Nuño V, Cano-Pumarega I, Corral- Peñafiel J, Arias E, Mediano O, Somoza-González M, Dalmau-Arias J, Almendros I, Farré R, Gozal D, García-Río F; Spanish Sleep Network. Obstructive sleep apnoea is related to melanoma aggressiveness through paraspeckle protein-1 upregulation. Eur Respir J. 2023 Feb 2;61(2):2200707.
Correlaciones entre la ingesta de sal en la dieta y la eliminación de sodio en la orina de 24 h en una muestra de población urbana de Cáceres [Correlations between dietary salt intake and 24-h urine sodium excretion in a sample of the urban population of Cáceres].
Referencia: Jiménez Rodríguez A, Palomo Cobos L, Rodríguez Martín A, Fernández Del Valle P, Novalbos-Ruiz JP. Correlaciones entre la ingesta de sal en la dieta y la
eliminación de sodio en la orina de 24 h en una muestra de población urbana de Cáceres [Correlations between dietary salt intake and 24-h urine sodium excretion in a sample of the urban population of Cáceres]. Aten Primaria. 2023 Jan;55(1):102513. Spanish.
Incidencia de cardiopatía isquémica en el estudio HERMEX y su asociación con los factores de riesgo cardiovascular clásicos [Incidence of ischemic heart disease in the HERMEX study and its association with classical cardiovascular risk factors].
Referencia: Fernández-Bergés D, Buitrago Ramírez F, Palomo Cobos L, Lozano Mera L, González-Fernández MR, Rubini A, Ramírez Moreno JM, Robles Pérez-Monteoliva NR, Félix-Redondo FJ. Incidencia de cardiopatía isquémica en el estudio HERMEX y su asociación con los factores de riesgo cardiovascular clásicos [Incidence of ischemic heart disease in the HERMEX study and its association with classical cardiovascular risk factors]. Semergen. 2022 Mar;48(2):88-95.
Pandemia de la COVID-19: efectos en la salud mental de los profesionales sanitarios [COVID-19 pandemic: Effects on the mental health of healthcare professionals].
Referencia: Buitrago Ramírez F, Ciurana Misol R, Fernández Alonso MDC, Tizón JL. Pandemia de la COVID-19: efectos en la salud mental de los profesionales sanitarios [COVID-19 pandemic: Effects on the mental health of healthcare professionals]. Aten Primaria. 2022 Jul;54(7):102359.
Long-term outcomes of extended DAPT in a real-life cohort of consecutive STEMI patients.
Referencia: Tizón-Marcos H, Toloba A, Subirana Cachinero I, Elosua R, Sionis A, Fernández-Avilés F, Bueno H, Carrillo A, Bayés A, Sánchez PL, Roqué M, Milà L, Elorriaga A, Vaquero J, Fernández-Bergés D, Bosch D, Alameda J, Martí Almor J, Jiménez-Navarro M, Martínez L, Sanchis J, Sánchez E, Rubert C, Ruiz-Valdepeñas L, Rodríguez M, Lozano Í, Abu-Assi E, González VB, Marrugat J. Long-term outcomes of extended DAPT in a real-life cohort of consecutive STEMI patients. Rev Esp Cardiol (Engl Ed). 2022 Dec 17:S1885-5857(22)00324-3.
Screening for cognitive impairment with the Montreal Cognitive Assessment in Spanish patients with minor stroke or transient ischaemic attack.
Referencia: Ramírez-Moreno JM, Bartolomé Alberca S, Muñoz Vega P, Guerrero Barona EJ. Screening for cognitive impairment with the Montreal Cognitive Assessment in Spanish patients with minor stroke or transient ischaemic attack. Neurologia (Engl Ed). 2022 Jan-Feb;37(1):38-44.
Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy.
Referencia: Mota-Zamorano S, González LM, Robles NR, Valdivielso JM, Arévalo-Lorido JC, López-Gómez J, Gervasini G. Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy. Ann Med. 2022 Dec;54(1):3039-3051.
Tag-SNPs in Phospholipase-Related Genes Modify the Susceptibility to Nephrosclerosis and its Associated Cardiovascular Risk.
Referencia: González LM, Robles NR, Mota-Zamorano S, Arévalo-Lorido JC, Valdivielso JM, López-Gómez J, Gervasini G. Tag-SNPs in Phospholipase-Related Genes Modify the Susceptibility to Nephrosclerosis and its Associated Cardiovascular Risk. Front Pharmacol. 2022 May 2;13:817020.
The psychological impact on frontline nurses in Spain of caring for people with COVID-19.
Referencia: Rodríguez-Martín B, Ramírez-Moreno JM, Caro-Alonso PÁ, Novo A, Martínez- Andrés M, Clavijo-Chamorro MZ, Rodríguez-Almagro J, López-Espuela F. The psychological impact on frontline nurses in Spain of caring for people with COVID-19. Arch Psychiatr Nurs. 2022 Dec;41:27-34.
La investigación en los servicios públicos de salud y su reconocimiento en las carreras profesionales de las comunidades autónomas en España [Research in public health services and its recognition in the professional careers in the regions of Spain].
Referencia: Félix-Redondo FJ, Cobaleda-Velasco M. La investigación en los servicios públicos de salud y su reconocimiento en las carreras profesionales de las comunidades autónomas en España [Research in public health services and its recognition in the professional careers in the regions of Spain]. Aten Primaria. 2022 Oct;54(10):102446.
Strength of association of classical vascular risk factors in young patients with ischaemic stroke: a case-control study.
Referencia: Ramírez-Moreno JM, Rebollo B, Macías-Sedas P, Valverde N, Parejo A, Felix-Redondo FJ, Roa Montero AM, Constantino AB, Gómez Baquero MJ, Ceberino-Muñoz D, Fernández-Bergés D. Strength of association of classical vascular risk factors in young patients with ischaemic stroke: a case-control study. Neurologia (Engl Ed). 2022 Oct 26:S2173-5808(22)00142-0.
Incidencia de cardiopatía isquémica en el estudio HERMEX y su asociación con los factores de riesgo cardiovascular clásicos [Incidence of ischemic heart disease in the HERMEX study and its association with classical cardiovascular risk factors].
Referencia: Fernández-Bergés D, Buitrago Ramírez F, Palomo Cobos L, Lozano Mera L, González-Fernández MR, Rubini A, Ramírez Moreno JM, Robles Pérez-Monteoliva NR, Félix-Redondo FJ. Incidencia de cardiopatía isquémica en el estudio HERMEX y su asociación con los factores de riesgo cardiovascular clásicos [Incidence of ischemic heart disease in the HERMEX study and its association with classical cardiovascular risk factors]. Semergen. 2022 Mar;48(2):88-95.
Frailty Health Team: The need of an interdisciplinary team and better clinical records.
Referencia: Fernández-Bergés D. Frailty Health Team: The need of an interdisciplinary team and better clinical records. Eur J Prev Cardiol. 2022 Aug 22:zwac181.
Correction to: Assessment of the cost of the Mediterranean diet in a low-income region: adherence and relationship with available incomes.
Referencia: Rubini A, Vilaplana-Prieto C, Flor-Alemany M, Yeguas-Rosa L, Hernández-González M, Félix-García FJ, Félix-Redondo FJ, Fernández-Bergés D. Correction to: Assessment of the cost of the Mediterranean diet in a low-income region: adherence and relationship with available incomes. BMC Public Health. 2022 Jan 21;22(1):149.
Evolución del perfil clínico y pronóstico de pacientes con alta hospitalaria por insuficiencia cardíaca en las dos primeras décadas del siglo xxi. El Registro INCA-Ex [Clinical and prognostic profile evolution of patients discharged from hospital due to heart failure in the first two decades of the 21st century. The INCA-Ex Registry].
Referencia: Fernández-Bergés D, González-Fernández R, Félix-Redondo FJ, Arevalo Lorido J, Yeguas Rosa L, Hernández-González M, Rubini A, Galán Montejano M, Gamero MC, Lozano Mera L. Evolución del perfil clínico y pronóstico de pacientes con alta hospitalaria por insuficiencia cardíaca en las dos primeras décadas del siglo xxi. El Registro INCA-Ex [Clinical and prognostic profile evolution of patients discharged from hospital due to heart failure in the first two decades of the 21st century. The INCA-Ex Registry]. Aten Primaria. 2022 Jul;54(7):102357.
Endarterectomy, Stenting, or Medical Treatment for Symptomatic Carotid Near-Occlusion: Results from CAOS, a Multicenter Registry Study.
Referencia: Garcia-Pastor A, Gil-Núñez A, Ramirez-Moreno JM, González-Nafría N, Tejada J, Moniche F, Portilla-Cuenca JC, Martínez-Sánchez P, Fuentes B, Gamero-García MA, de Leciñana MA, Masjuan J, Verge DC, Aladro Y, Parkhutik V, Lago A, de Arce-Borda AM, Usero-Ruiz M, Delgado-Mederos R, Pampliega A, Ximenez-Carrillo Á, Bártulos-Iglesias M, Castro-Reyes E; Stroke Project of the Spanish Cerebrovascular Diseases Study Group. Endarterectomy, Stenting, or Medical Treatment for Symptomatic Carotid Near-Occlusion: Results from CAOS, a Multicenter Registry Study. AJNR Am J Neuroradiol. 2022 Sep;43(9):1304-1310.
Prevención de los trastornos de la salud mental. Embarazo en la adolescencia [Prevention of mental health disorders in primary care: Pregnancy in adolescence].
Referencia: Buitrago Ramírez F, Ciurana Misol R, Fernández Alonso MDC, Tizón JL; Miembros del Grupo de Salud Mental. Prevención de los trastornos de la salud mental. Embarazo en la adolescencia [Prevention of mental health disorders in primary care: Pregnancy in adolescence]. Aten Primaria. 2022 Oct;54 Suppl 1(Suppl1):102494.
Historical Archive of Blood Pressure and Evolution of Hypertension.
Referencia: Tengiz I, Fıcı F, Ercan E, Grassi G, Robles NR, Faikoglu G, Historical Archive of Blood Pressure and Evolution of Hypertension. Journal of Drug Delivery and Therapeutics. 2022; 12(3):215-219.
Prevención de los trastornos de la salud mental. Hijos de familias monoparentales [Prevention of mental health disorders in primary care: Children of single-parent families. Pregnancy in adolescence].
Referencia: Buitrago Ramírez F, Ciurana Misol R, Fernández Alonso MDC, Tizón JL; Miembros del Grupo de Salud Mental. Prevención de los trastornos de la salud mental. Hijos de familias monoparentales [Prevention of mental health disorders in primary care: Children of single-parent families. Pregnancy in adolescence]. Aten Primaria. 2022 Oct;54 Suppl 1(Suppl 1):102445.
Tag-SNPs in Phospholipase-Related Genes Modify the Susceptibility to Nephrosclerosis and its Associated Cardiovascular Risk.
Referencia: González LM, Robles NR, Mota-Zamorano S, Arévalo-Lorido JC, Valdivielso JM, López-Gómez J, Gervasini G. Tag-SNPs in Phospholipase-Related Genes Modify the Susceptibility to Nephrosclerosis and its Associated Cardiovascular Risk. Front Pharmacol. 2022 May 2;13:817020.
Cognitive Function and Neuropsychiatric Disorders after COVID-19: A Long Term Social and Clinical Problem?
Referencia: Ramírez Moreno JM, Muñoz Sanz A, Vaz-Leal FJ. Cognitive Function and Neuropsychiatric Disorders after COVID-19: A Long Term Social and Clinical Problem? BioMed 2022, 2(1), 50-59
Assessment of the Cost of the Mediterranean Diet in a Low-Income Region: Adherence and Relationship with Available Incomes.
Referencia: Rubini A, Vilaplana-Prieto C, Flor-Alemany M, Yeguas-Rosa L, Hernández-González M, Félix-García FJ, Félix-Redondo FJ, Fernández-Bergés D. Assessment of the Cost of the Mediterranean Diet in a Low-Income Region: Adherence and Relationship with Available Incomes. BMC Public Health. 2022 Jan 10;22(1):58.
The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress.
Referencia: Yakhine-Diop SMS, Rodríguez-Arribas M, Canales-Cortés S, Martínez-Chacón G, Uribe-Carretero E, Blanco-Benítez M, Duque-González G, Paredes-Barquero M, Alegre-Cortés E, Climent V, Aiastui A, López de Munain A, Bravo-San Pedro JM, Niso-Santano M, Fuentes JM, González-Polo RA. The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress. Cell Biol Toxicol. 2022 Oct;38(5):889-911.
Delay of EGF-Stimulated EGFR Degradation in Myotonic Dystrophy Type 1 (DM1).
Referencia: Alegre-Cortés E, Giménez-Bejarano A, Uribe-Carretero E, Paredes-Barquero M, Marques ARA, Lopes-da-Silva M, Vieira OV, Canales-Cortés S, Camello PJ, Martínez-Chacón G, Aiastui A, Fernández-Torrón R, López de Munain A, Gomez-Suaga P, Niso-Santano M, González-Polo RA, Fuentes JM, Yakhine-Diop SMS. Delay of EGF-Stimulated EGFR Degradation in Myotonic Dystrophy Type 1 (DM1). Cells. 2022 Sep 27;11(19):3018.
Fibrilación auricular y deterioro cognitivo: una revisión narrativa [Atrial fibrillation and cognitive impairment: a narrative review].
Referencia: Morales-Bacas E, Duque-Holguera M, Portilla-Cuenca JC, Casado-Naranjo I. Fibrilación auricular y deterioro cognitivo: una revisión narrativa [Atrial fibrillation and cognitive impairment: a narrative review]. Rev Neurol. 2022 Nov 16;75(10):311-318.
Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson´s Disease: The Implication of Lipid Droplets and Lipophagy.
Referencia: Alarcon-Gil J, Sierra-Magro A, Morales-Garcia JA, Sanz-SanCristobal M, Alonso-Gil S, Cortes-Canteli M, Niso-Santano M, Martínez-Chacón G, Fuentes JM, Santos A, Perez-Castillo A. Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson´s Disease: The Implication of Lipid Droplets and Lipophagy. Cells. 2022 Jul 26;11(15):2297.
Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles.
Referencia: Uribe-Carretero E, Martinez-Chacón G, Yakhine-Diop SMS, Duque-González G, Rodríguez-Arribas M, Alegre-Cortés E, Paredes-Barquero M, Canales-Cortés S, Pizarro-Estrella E, Cuadrado A, González-Polo RA, Fuentes JM, Niso-Santano M. Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles. Antioxidants (Basel). 2022 Jul 19;11(7):1398.
In vitro and in vivo models to study the biological and pharmacological properties of queen bee acid (QBA, 10-hydroxy-2-decenoic acid): A systematic review.
Referencia: Paredes-Barquero M, Niso-Santano M, Fuentes JM, Martínez-Chacón G. In vitro and in vivo models to study the biological and pharmacological properties of queen bee acid (QBA, 10-hydroxy-2-decenoic acid): A systematic review. Journal of Functional Foods. 2022: 94, 105143.
Decomposition of Growth Curves into Growth Rate and Acceleration: a Novel Procedure To Monitor Bacterial Growth and the Time-Dependent Effect of Antimicrobials.
Referencia: Navarro-Pérez ML, Fernández-Calderón MC, Vadillo-Rodríguez V. Decomposition of Growth Curves into Growth Rate and Acceleration: a Novel Procedure To Monitor Bacterial Growth and the Time-Dependent Effect of Antimicrobials. Appl Environ Microbiol. 2022 Feb 8;88(3):e0184921.
Role of Inflammatory Cytokines in the Conversion of Mild Cognitive Impairment to Dementia: A Prospective Study.
Referencia: Romero-Sevilla R, López-Espuela F, Fuentes JM, de San Juan BD, Portilla-Cuenca JC, Hijon CC, Casado-Naranjo I. Role of Inflammatory Cytokines in the Conversion of Mild Cognitive Impairment to Dementia: A Prospective Study. Curr Alzheimer Res. 2022;19(1):68-75.
Antibacterial and Antibiofilm Activity of Carvacrol against Oral Pathogenic Bacteria.
Referencia: Fernández-Babiano I, Navarro-Pérez ML, Pérez-Giraldo C, Fernández-Calderón MC. Antibacterial and Antibiofilm Activity of Carvacrol against Oral Pathogenic Bacteria. Metabolites. 2022 Dec 13;12(12):1255.
Modification of physico-chemical surface properties and growth of Staphylococcus aureus under hyperglycemia and ketoacidosis conditions.
Referencia: Fernández-Grajera M, Pacha-Olivenza MA, Gallardo-Moreno AM, González-Martín ML, Pérez-Giraldo C, Fernández-Calderón MC. Modification of physico-chemical surface properties and growth of Staphylococcus aureus under hyperglycemia and ketoacidosis conditions. Colloids Surf B Biointerfaces. 2022 Jan;209(Pt1):112137.
Bacterial Response to the Surface Aging of PLA Matrices Loaded with Active Compounds.
Referencia: Fernández-Grajera M, Gallardo-Moreno AM, Luque-Agudo V, González-Martín ML, Hierro-Oliva M. Bacterial Response to the Surface Aging of PLA Matrices Loaded with Active Compounds. Polymers (Basel). 2022 Nov 17;14(22):4976.
From radial to unidirectional water pumping in zeta-potential modulated Nafion nanostructures.
Referencia: Esplandiu MJ, Reguera D, Romero-Guzmán D, Gallardo-Moreno AM, Fraxedas J. From radial to unidirectional water pumping in zeta-potential modulated Nafion nanostructures. Nat Commun. 2022 May 19;13(1):2812.
Decomposition of Growth Curves into Growth Rate and Acceleration: a Novel Procedure To Monitor Bacterial Growth and the Time-Dependent Effect of Antimicrobials.
Referencia: Navarro-Pérez ML, Fernández-Calderón MC, Vadillo-Rodríguez V. Decomposition of Growth Curves into Growth Rate and Acceleration: a Novel Procedure To Monitor Bacterial Growth and the Time-Dependent Effect of Antimicrobials. Appl Environ Microbiol. 2022 Feb 8;88(3):e0184921.
Modification of physico-chemical surface properties and growth of Staphylococcus aureus under hyperglycemia and ketoacidosis conditions.
Referencia: Fernández-Grajera M, Pacha-Olivenza MA, Gallardo-Moreno AM, González-Martín ML, Pérez-Giraldo C, Fernández-Calderón MC. Modification of physico-chemical surface properties and growth of Staphylococcus aureus under hyperglycemia and ketoacidosis conditions. Colloids Surf B Biointerfaces. 2022 Jan;209(Pt1):112137.
Identification of environmental factors that promote intestinal inflammation.
Referencia: Sanmarco LM, Chao CC, Wang YC, Kenison JE, Li Z, Rone JM, Rejano-Gordillo CM, Polonio CM, Gutierrez-Vazquez C, Piester G, Plasencia A, Li L, Giovannoni F, Lee HG, Faust Akl C, Wheeler MA, Mascanfroni I, Jaronen M, Alsuwailm M, Hewson P, Yeste A, Andersen BM, Franks DG, Huang CJ, Ekwudo M, Tjon EC, Rothhammer V, Takenaka M, de Lima KA, Linnerbauer M, Guo L, Covacu R, Queva H, Fonseca-Castro PH, Bladi MA, Cox LM, Hodgetts KJ, Hahn ME, Mildner A, Korzenik J, Hauser R, Snapper SB, Quintana FJ. Identification of environmental factors that promote intestinal inflammation. Nature. 2022 Nov;611(7937):801-809.
Adenoma tubulopapilar quístico con diferenciación apocrina: descripción de un caso con mutación de BRAF V600E y revisión de la literatura [Cystic tubulopapillary adenoma with apocrine differentiation and BRAF V600E mutation. A case report and review of the literature].
Referencia: Moreno Ontalba A, Gómez Durán Á, Ruiz Cabezas L, Cidoncha Pérez E, Díaz Delgado M, Rubio Fernández A. Adenoma tubulopapilar quístico con diferenciación apocrina: descripción de un caso con mutación de BRAF V600E y revisión de la literatura [Cystic tubulopapillary adenoma with apocrine differentiation and BRAF V600E mutation. A case report and review of the literature]. Rev Esp Patol. 2022 Sep;55 Suppl 1:S64-S68.
Liver resection in elderly patients with extensive CRLM: Are we offering an adequate treatment? A propensity score matched analysis.
Referencia: Di Martino M, Dorcaratto D, Primavesi F, Syn N, Blanco-Terés L, Dupré A, Piardi T, Rhaiem R, Fernández GB, De Armas Conde N, Rodríguez Sanjuán JC, Santiago RF, Fernández-Moreno MC, Ferret G, Ben SL, Suárez Muñoz MÁ, Perez-Alonso AJ, Koh YX, Jones R, Vennarecci G, Martín-Pérez E. Liver resection in elderly patients with extensive CRLM: Are we offering an adequate treatment? A propensity score matched analysis. Eur J Surg Oncol. 2022 Jun;48(6):1331-1338.
Reaching a consensus on the definition of "difficult" cholecystectomy among Spanish experts. A Delphi project. A qualitative study.
Referencia: Manuel-Vázquez A, Latorre-Fragua R, Alcázar C, Requena PM, de la Plaza R, Blanco Fernández G, Serradilla-Martín M, Ramia JM; SCORELAP group. Reaching a consensus on the definition of "difficult" cholecystectomy among Spanish experts. A Delphi project. A qualitative study. Int J Surg. 2022 Jun;102:106649.
Prognostic value of pre-operative systemic immune-inflammation index and platelet to lymphocyte ratio in peritoneal carcinomatosis of ovarian origin.
Referencia: Ramón-Rodríguez J, De-Armas-Conde N, Jaén-Torrejimeno I, Prada-Villaverde A, Rojas-Holguín A, López-Guerra D, Blanco-Fernández G. Prognostic value of pre-operative systemic immune-inflammation index and platelet to lymphocyte ratio in peritoneal carcinomatosis of ovarian origin. Surg Oncol. 2022 Jun;42:101750.
ASO Visual Abstract: Long-Term Outcomes of Perioperative versus Neoadjuvant Chemotherapy for Resectable Colorectal Liver Metastases-An International Multicenter Propensity-Score Matched Analysis with Stratification by Contemporary Risk Scoring.
Referencia: Di Martino M, Primavesi F, Syn N, Dorcaratto D, de la Hoz Rodríguez Á, Dupré A, Piardi T, Rhaiem R, Blanco Fernández G, de Armas Conde N, Rodríguez Sanjuán JC, Fernández Santiago R, Fernández-Moreno MC, Ferret G, López Ben S, Suárez Muñóz MÁ, Perez-Alonso AJ, Koh YX, Jones R, Martín-Pérez E. ASO Visual Abstract: Long-Term Outcomes of Perioperative versus Neoadjuvant Chemotherapy for Resectable Colorectal Liver Metastases-An International Multicenter Propensity-Score Matched Analysis with Stratification by Contemporary Risk Scoring. Ann Surg Oncol. 2022 Oct;29(11):6845-6846.
Surgical treatment of liver hydatid cyst in elderly patients: A propensity score-matching retrospective cohort study.
Referencia: Jaén-Torrejimeno I, López-Guerra D, Rojas-Holguín A, De-Armas-Conde N, Blanco-Fernández G. Surgical treatment of liver hydatid cyst in elderly patients: A propensity score-matching retrospective cohort study. Acta Trop. 2022 Aug;232:106466.
Pancreatic mucinous cystic neoplasms located in the distal pancreas: a multicenter study.
Referencia: Ramia JM, Del Rio Martín J, Blanco-Fernández G, Cantalejo-Diaz M, Pardo F, Muñoz-Forner E, Carabias A, Manuel-Vazquez A, Hernández-Rivera PJ, Jaén-Torrejimeno I, Kälviäinen-Mejia HK, Rotellar-Sastre F, Garcés-Albir M, Latorre R, Longoria-Dubocq T, De Armas-Conde N, Serrablo-Requejo A, Esteban Gordillo S, Sabater L, Serradilla-Martín M. Pancreatic mucinous cystic neoplasms located in the distal pancreas: a multicenter study. Gland Surg. 2022 May;11(5):795-804.
Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells.
Referencia: Nacarino-Palma A, Rico-Leo EM, Campisi J, Ramanathan A, González-Rico FJ, Rejano-Gordillo CM, Ordiales-Talavero A, Merino JM, Fernández-Salguero PM. Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells. Aging (Albany NY). 2022 May 26;14(10):4281-4304.
From Nucleus to Organs: Insights of Aryl Hydrocarbon Receptor Molecular Mechanisms.
Referencia: Rejano-Gordillo CM, Marín-Díaz B, Ordiales-Talavero A, Merino JM, González-Rico FJ, Fernández-Salguero PM. From Nucleus to Organs: Insights of Aryl Hydrocarbon Receptor Molecular Mechanisms. Int J Mol Sci. 2022 Nov 29;23(23):14919.
Aryl Hydrocarbon Receptor: From Homeostasis to Tumor Progression.
Referencia: Rejano-Gordillo C, Ordiales-Talavero A, Nacarino-Palma A, Merino JM, González-Rico FJ, Fernández-Salguero PM. Aryl Hydrocarbon Receptor: From Homeostasis to Tumor Progression. Front Cell Dev Biol. 2022 Apr 7;10:884004.
Dynamic BOLD MRI Shows Greater Foot Ischemia and Blunted Reperfusion Following Cuff-Occlusion Challenge in Diabetic Patients with Foot Ulcers.
Referencia: Scott J. Edwards, Jingting Yao, Marcos Coutinho Schechter, Maya Fayfman, Gabriel Santamarina, Paula Nesbeth, Vincent Giacalone, Gerado Blanco, Rabindra Tirouvanziam, Jessica Alvarez, Benjamin Risk, Ravi Rajani, and David A. Reiter. Dynamic BOLD MRI Shows Greater Foot Ischemia and Blunted Reperfusion Following Cuff-Occlusion Challenge in Diabetic Patients with Foot Ulcers. ISMRM-ESMRMB ISMRT 31st Annual Meeting, 2022
Elevated Foot Diffusion and Resting Perfusion in Patients with Diabetic Foot Ulcer: A Pilot and Feasibility Study.
Referencia: David A Reiter, Jingting Yao, Scott Edwards, Marcos Coutinho Schechter, Maya Fayfman, Gabriel Santamarina, Paula Nesbeth, Vincent Giacalone, Gerardo Blanco, Thorsten Feiweier, Rabindra Tirouvanziam, Jessica Alvarez, Benjamine Risk, and Ravi Rajani. Elevated Foot Diffusion and Resting Perfusion in Patients with Diabetic Foot Ulcer: A Pilot and Feasibility Study. ISMRM-ESMRMB ISMRT 31st Annual Meeting, 2022.
Resection of isolated pancreatic metastases from pulmonary neoplasia: a systematic review.
Referencia: Jaén-Torrejimeno I, López-Guerra D, Rojas-Holguín A, De-Armas-Conde N, Blanco-Fernández G. Resection of isolated pancreatic metastases from pulmonary neoplasia: a systematic review. Updates Surg. 2022 Dec;74(6):1817-1825.
Liver regeneration after partial hepatectomy is improved in the absence of aryl hydrocarbon receptor.
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Adenosquamous cancer of the pancreas: A multicenter retrospective study.
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Influence of the tumor site and histopathology after resection for non-colorectal non-neuroendocrine liver metastases. A single center experience.
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Effectiveness of CPAP vs. Noninvasive Ventilation Based on Disease Severity in Obesity Hypoventilation Syndrome and Concomitant Severe Obstructive Sleep Apnea.
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International Consensus Document on Obstructive Sleep Apnea.
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Primary versus Specialist Care for Obstructive Sleep Apnea: A Systematic Review and Individual-Participant Data-Level Meta-Analysis.
Referencia: Van Ryswyk EM, Benitez ID, Sweetman AM, Nadal N, Chai-Coetzer CL, Masa JF, Gómez de Terreros FJ, Adams RJ, Sánchez-de-la-Torre M, Stocks N, Kaambwa B, McEvoy RD, Barbé F. Primary versus Specialist Care for Obstructive Sleep Apnea: A Systematic Review and Individual-Participant Data-Level Meta-Analysis. Ann Am Thorac Soc. 2022 Apr;19(4):668-677.
Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome.
Referencia: Zapater A, Solelhac G, Sánchez-de-la-Torre A, Gracia-Lavedan E, Benitez ID, Torres G, De Batlle J, Haba-Rubio J, Berger M, Abad J, Duran-Cantolla J, Urrutia A, Mediano O, Masdeu MJ, Ordax-Carbajo E, Masa JF, De la Peña M, Mayos M, Coloma R, Montserrat JM, Chiner E, Mínguez O, Pascual L, Cortijo A, Martínez D, Dalmases M, Lee CH, McEvoy RD, Barbé F, Heinzer R, Sánchez-de-la-Torre M; Spanish Sleep Network. Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome. Front Med (Lausanne). 2022 Jun 27;9:870906.
Long-Term Effect of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Treatment on Blood Pressure in Patients with Acute Coronary Syndrome: A Clinical Trial.
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Effect of CPAP treatment on BP in resistant hypertensive patients according to the BP dipping pattern and the presence of nocturnal hypertension.
Referencia: Sapiña-Beltrán E, Benitez ID, Torres G, Fortuna-Gutiérrez AM, Ponte Márquez P, Masa JF, Drager LF, Cabrini M, Félez M, Vázquez S, Abad J, Lee C, García-Río F, Casitas R, Mediano O, Romero Peralta S, Martínez D, Sánchez-de-la-Torre M, Barbé F, Dalmases M. Effect of CPAP treatment on BP in resistant hypertensive patients according to the BP dipping pattern and the presence of nocturnal hypertension. Hypertens Res. 2022 Mar;45(3):436-444.
Effectiveness of CPAP vs. Noninvasive Ventilation Based on Disease Severity in Obesity Hypoventilation Syndrome and Concomitant Severe Obstructive Sleep Apnea.
Referencia: Masa JF, Benítez ID, Sánchez-Quiroga MÁ, Gomez de Terreros FJ, Corral J, Romero A, Caballero-Eraso C, Ordax-Carbajo E, Troncoso MF, González M, López- Martín S, Marin JM, Martí S, Díaz-Cambriles T, Chiner E, Egea C, Barca J, Vázquez-Polo FJ, Negrín MA, Martel-Escobar M, Barbé F, Mokhlesi B; Spanish Sleep Network; Authors from Spanish Sleep Network. Effectiveness of CPAP vs. Noninvasive Ventilation Based on Disease Severity in Obesity Hypoventilation Syndrome and Concomitant Severe Obstructive Sleep Apnea. Arch Bronconeumol. 2022 Mar;58(3):228-236.
International Consensus Document on Obstructive Sleep Apnea.
Referencia: Mediano O, González Mangado N, Montserrat JM, Alonso-Álvarez ML, Almendros I, Alonso-Fernández A, Barbé F, Borsini E, Caballero-Eraso C, Cano-Pumarega I, de Carlos Villafranca F, Carmona-Bernal C, Carrillo Alduenda JL, Chiner E, Cordero Guevara JA, de Manuel L, Durán-Cantolla J, Farré R, Franceschini C, Gaig C, Garcia Ramos P, García-Río F, Garmendia O, Gómez García T, González Pondal S, Hoyo Rodrigo MB, Lecube A, Madrid JA, Maniegas Lozano L, Martínez Carrasco JL, Masa JF, Masdeu Margalef MJ, Mayos Pérez M, Mirabet Lis E, Monasterio C, Navarro Soriano N, Olea de la Fuente E, Plaza G, Puertas Cuesta FJ, Rabec C, Resano P, Rigau D, Roncero A, Ruiz C, Salord N, Saltijeral A, Sampol Rubio G, Sánchez Quiroga MÁ, Sans Capdevila Ó, Teixeira C, Tinahones Madueño F, Maria Togeiro S, Troncoso Acevedo MF, Vargas Ramírez LK, Winck J, Zabala Urionaguena N, Egea C; el Spanish Sleep Network. International Consensus Document on Obstructive Sleep Apnea. Arch Bronconeumol. 2022 Jan;58(1):52-68.
International Consensus Document on Obstructive Sleep Apnea.
Referencia: Mediano O, González Mangado N, Montserrat JM, Alonso-Álvarez ML, Almendros I, Alonso-Fernández A, Barbé F, Borsini E, Caballero-Eraso C, Cano-Pumarega I, de Carlos Villafranca F, Carmona-Bernal C, Carrillo Alduenda JL, Chiner E, Cordero Guevara JA, de Manuel L, Durán-Cantolla J, Farré R, Franceschini C, Gaig C, Garcia Ramos P, García-Río F, Garmendia O, Gómez García T, González Pondal S, Hoyo Rodrigo MB, Lecube A, Madrid JA, Maniegas Lozano L, Martínez Carrasco JL, Masa JF, Masdeu Margalef MJ, Mayos Pérez M, Mirabet Lis E, Monasterio C, Navarro Soriano N, Olea de la Fuente E, Plaza G, Puertas Cuesta FJ, Rabec C, Resano P, Rigau D, Roncero A, Ruiz C, Salord N, Saltijeral A, Sampol Rubio G, Sánchez Quiroga MÁ, Sans Capdevila Ó, Teixeira C, Tinahones Madueño F, Maria Togeiro S, Troncoso Acevedo MF, Vargas Ramírez LK, Winck J, Zabala Urionaguena N, Egea C; el Spanish Sleep Network. International Consensus Document on Obstructive Sleep Apnea. Arch Bronconeumol. 2022 Jan;58(1):52-68.
Primary versus Specialist Care for Obstructive Sleep Apnea: A Systematic Review and Individual Participant Data-Level Meta-Analysis.
Referencia: Van Ryswyk EM, Benitez ID, Sweetman AM, Nadal N, Chai-Coetzer CL, Masa JF, Gómez de Terreros FJ, Adams RJ, Sánchez-de-la-Torre M, Stocks N, Kaambwa B, McEvoy RD, Barbé F. Primary versus Specialist Care for Obstructive Sleep Apnea: A Systematic Review and Individual Participant Data-Level Meta-Analysis. Ann Am Thorac Soc. 2022 Apr;19(4):668-677.
An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.
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The Influence of Obesity and Weight Loss on the Bioregulation of Innate/Inflammatory Responses: Macrophages and Immunometabolism.
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An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.
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Influence of Codiagnosis of Chronic Fatigue Syndrome and Habitual Physical Exercise on the Psychological Status and Quality of Life of Patients with Fibromyalgia.
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Case report: is there a link between morning glory syndrome and TANGO2 mutation disease, or is this an unusual association?
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Balneotherapy year in review 2021: focus on the mechanisms of action of balneotherapy in rheumatic diseases.
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Answer to the Letter to the Editor: Methotrexate in interstitial lung disease associated with rheumatoid arthritis.
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A Systematic Review of the Effectiveness of Virtual Reality-Based Interventions on Pain and Range of Joint Movement Associated with Burn Injuries.
Referencia: Garrido-Ardila EM, Santos-Domínguez M, Rodríguez-Mansilla J, Torres-Piles ST, Rodríguez-Domínguez MT, González-Sánchez B, Jiménez-Palomares M. A Systematic Review of the Effectiveness of Virtual Reality-Based Interventions on Pain and Range of Joint Movement Associated with Burn Injuries. J Pers Med. 2022 Jul 31;12(8):1269.
Recommendations for prevention of infection in systemic autoimmune rheumatic diseases.
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Acute intermittent porphyria: is oseltamivir safe in these patients?
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Incidence and factors associated with COVID-19 in 13 hemodialysis units.
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A one-year follow-up study of treatment-compliant suicide attempt survivors: relationship of CYP2D6-CYP2C19 and polypharmacy with suicide reattempts.
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Current perspectives on interethnic variability in multiple myeloma: Single cell technology, population pharmacogenetics and molecular signal transduction.
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Pharmacogenetics of Metformin Transporters Suggests No Association with Therapeutic Inefficacy among Diabetes Type 2 Mexican Patients.
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Frequency of CYP2C9 Promoter Variable Number Tandem Repeat Polymorphism in a Spanish Population: Linkage Disequilibrium with CYP2C9*3 Allele.
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Pharmacogenetics research in Brazil: a systematic review.
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Pharmacogenetics research in Brazil: a systematic review.
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An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.
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Effects of dapagliflozin on mortality in patients with chronic kidney disease: a pre-specified analysis from the DAPA-CKD randomized controlled trial.
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Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight.
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Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population representative studies with 104 million participants.
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Impact of the COVID-19 pandemic on the clinical practice of strokes in a region of the health system of Spain.
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Genetic Variants in PGE2 Receptors Modulate the Risk of Nephrosclerosis and Clinical Outcomes in These Patients.
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Evaluation of the mediterranean diet cost in Extremadura: adherence and relationship with available income
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Study of the effect of chronic kidney disease on the incidence of cardiovascular events in a native Spanish population.
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[COVID-19 pandemic and mental health: Initial considerations from spanish primary health care].
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[Impact of the COVID-19 pandemic on the mental health of the general population: Reflections and proposals].
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[Prevalence and degree of control of cardiovascular risk factors in patients with ischemic cardiopathy of an urban health center.].
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Referencia: Nacarino-Palma A, Rejano-Gordillo CM, González-Rico FJ, Ordiales-Talavero A, Román ÁC, Cuadrado M, Bustelo XR, Merino JM, Fernández-Salguero PM. Loss of Aryl Hydrocarbon Receptor Favors K-Ras G12D -Driven Non-Small Cell Lung Cancer. Cancers (Basel). 2021 Aug 13;13(16):4071.
Durvalumab as a Successful Downstaging Therapy for Liver Transplantation in Hepatocellular Carcinoma
Referencia: Sogbe M, López-Guerra D, Blanco-Fernández G, Sangro B, Narváez-Rodriguez I. Durvalumab as a Successful Downstaging Therapy for Liver Transplantation in Hepatocellular Carcinoma: The Importance of a Washout Period. Transplantation. 2021 Dec 1;105(12):e398-e400.
Melatonin Modulates the Antioxidant Defenses and the Expression of Proinflammatory Mediators in Pancreatic Stellate Cells Subjected to Hypoxia
Referencia: Estaras M, Gonzalez-Portillo MR, Martinez R, Garcia A, Estevez M, Fernandez- Bermejo M, Mateos JM, Vara D, Blanco-Fernández G, Lopez-Guerra D, Roncero V, Salido GM, Gonzalez A. Melatonin Modulates the Antioxidant Defenses and the Expression of Proinflammatory Mediators in Pancreatic Stellate Cells Subjected to Hypoxia. Antioxidants (Basel). 2021 Apr 8;10(4):577.
Prospective Study Correlating External Biliary Stenting and Pancreatic Fistula Following Pancreaticoduodenectomy
Referencia: Blanco-Fernández G, Jaén-Torrejimeno I, De-Armas-Conde N, Rojas-Holguín A, Naharro JS, Castillo Tuñón JM, López-Guerra D. Prospective Study Correlating External Biliary Stenting and Pancreatic Fistula Following Pancreaticoduodenectomy. J Gastrointest Surg. 2021 Nov;25(11):2881-2888.
Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients.
Referencia: Colmenero J, Rodríguez-Perálvarez M, Salcedo M, Arias-Milla A, Muñoz-Serrano A, Graus J, Nuño J, Gastaca M, Bustamante-Schneider J, Cachero A, Lladó L, Caballero A, Fernández-Yunquera A, Loinaz C, Fernández I, Fondevila C, Navasa M, Iñarrairaegui M, Castells L, Pascual S, Ramírez P, Vinaixa C, González-Dieguez ML, González-Grande R, Hierro L, Nogueras F, Otero A, Álamo JM, Blanco-Fernández G, Fábrega E, García-Pajares F, Montero JL, Tomé S, De la Rosa G, Pons JA. Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients. J Hepatol. 2021 Jan;74(1):148-155.
Prospective Study Correlating External Biliary Stenting and Pancreatic Fistula Following Pancreaticoduodenectomy.
Referencia: Blanco-Fernández G, Jaén-Torrejimeno I, De-Armas-Conde N, Rojas-Holguín A, Naharro JS, Castillo Tuñón JM, López-Guerra D. Prospective Study Correlating External Biliary Stenting and Pancreatic Fistula Following Pancreaticoduodenectomy. J Gastrointest Surg. 2021 Nov;25(11):2881-2888.
Implementation of a regional reference center in pancreatic surgery. Experience after 631 procedures.
Referencia: Castillo Tuñón JM, Valle Rodas ME, Botello Martínez F, Rojas Holguín A, López Guerra D, Santos Naharro J, Jaén Torrejímeno I, Blanco Fernández G. Implementation of a regional reference center in pancreatic surgery. Experience after 631 procedures. Cir Esp (Engl Ed). 2021 Dec;99(10):745-756.
Jaundice as a clinical presentation in liver hydatidosis increases the risk of postoperative biliary fistula.
Referencia: Jaén-Torrejimeno I, Latorre-Fragua R, López-Guerra D, Rojas-Holguín A, Manuel-Vázquez A, Blanco Fernández G, Ramia JM. Jaundice as a clinical presentation in liver hydatidosis increases the risk of postoperative biliary fistula. Langenbecks Arch Surg. 2021 Jun;406(4):1139-1147.
Melatonin Induces Apoptosis and Modulates Cyclin Expression and MAPK Phosphorylation in Pancreatic Stellate Cells Subjected to Hypoxia.
Referencia: Estaras M, Gonzalez-Portillo MR, Fernandez-Bermejo M, Mateos JM, Vara D, Blanco-Fernandez G, Lopez Guerra D, Roncero V, Salido GM, González A. Melatonin Induces Apoptosis and Modulates Cyclin Expression and MAPK Phosphorylation in Pancreatic Stellate Cells Subjected to Hypoxia. Int J Mol Sci. 2021 May 24;22(11):5555.
Perioperative chemotherapy versus surgery alone for resectable colorectal liver metastases: an international multicentre propensity score matched analysis on long-term outcomes according to established prognostic risk scores.
Referencia: Di Martino M, Primavesi F, Syn N, Dorcaratto D, de la Hoz Rodríguez Á, Dupré A, Piardi T, Rhaiem R, Blanco Fernández G, Prada Villaverde A, Rodríguez Sanjuán JC, Fernández Santiago R, Fernández Moreno MC, Ferret G, López Ben S, Suárez Muñoz MÁ, Perez-Alonso AJ, Koh YX, Jones R, Martín-Pérez E. Perioperative chemotherapy versus surgery alone for resectable colorectal liver metastases: an international multicentre propensity score matched analysis on long-term outcomes according to established prognostic risk scores. HPB (Oxford). 2021 Dec;23(12):1873-1885.
Preoperative hepatic artery embolization before distal pancreatectomy plus celiac axis resection does not improve surgical results: A Spanish multicentre study.
Referencia: Ramia JM, de Vicente E, Pardo F, Sabater L, Lopez-Ben S, Quijano M Y, Villegas T, Blanco-Fernandez G, Diez-Valladares L, Lopez-Rojo I, Martin-Perez E, Pereira F, Gonzalez AJ, Herrera J, García-Domingo MI, Serradilla-Martín M. Preoperative hepatic artery embolization before distal pancreatectomy plus celiac axis resection does not improve surgical results: A Spanish multicentre study. Surgeon. 2021 Oct;19(5):e117-e124.
Summary of Recommendations and Key Points of the Consensus of Spanish Scientific Societies (SEPAR, SEMICYUC, SEMES, SECIP, SENEO, SEDAR, SENP) on the Use of Non-Invasive Ventilation and High-Flow Oxygen Therapy with Nasal Cannulas in Adult, Pediatric, and Neonatal Patients With Severe Acute Respiratory Failure.
Referencia: Luján M, Peñuelas Ó, Cinesi Gómez C, García-Salido A, Moreno Hernando J, Romero Berrocal A, Gutiérrez Ibarluzea I, Masa Jiménez JF, Mas A, Carratalá Perales JM, Gaboli M, Concheiro Guisán A, García Fernández J, Escámez J, Parrilla Parrilla J, Farrero Muñoz E, González M, Heili-Frades SB, Sánchez Quiroga MÁ, Rialp Cervera G, Hernández G, Sánchez Torres A, Uña R, Ferrando Ortolà C, Ferrer Monreal M, Egea Santaolalla C. Summary of Recommendations and Key Points of the Consensus of Spanish Scientific Societies (SEPAR, SEMICYUC, SEMES; SECIP, SENEO, SEDAR, SENP) on the Use of Non-Invasive Ventilation and High-Flow Oxygen Therapy with Nasal Cannulas in Adult, Pediatric, and Neonatal Patients With Severe Acute Respiratory Failure. Arch Bronconeumol (Engl Ed). 2021 Jun;57(6):415-427.
Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia: a systematic review and individual participant data meta-analysis.
Referencia: Lebret M, Léotard A, Pépin JL, Windisch W, Ekkernkamp E, Pallero M, Sánchez- Quiroga MÁ, Hart N, Kelly JL, Patout M, Funk GC, Duiverman ML, Masa JF, Simonds A, Murphy PB, Wijkstra PJ, Dreher M, Storre J, Khouri C, Borel JC. Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia: a systematic review and individual participant data meta-analysis. Thorax. 2021 Nov;76(11):1108-1116.
The HIPARCO-2 study: long-term effect of continuous positive airway pressure on blood pressure in patients with resistant hypertension: a multicenter prospective study.
Referencia: Navarro-Soriano C, Torres G, Barbé F, Sánchez-de-la-Torre M, Mañas P, Lloberes P, Cambriles TD, Somoza M, Masa JF, González M, Mañas E, de la Peña M, García-Río F, Montserrat JM, Muriel A, Oscullo G, García-Ortega A, Posadas T, Campos-Rodríguez F, Martínez-García MÁ; on behalf the Spanish Sleep Network. The HIPARCO-2 study: long-term effect of continuous positive airway pressure on blood pressure in patients with resistant hypertension: a multicenter prospective study. J Hypertens. 2021 Feb 1;39(2):302-309.
Association of Obstructive Sleep Apnea with the Aging Process.
Referencia: Pinilla L, Santamaria-Martos F, Benítez ID, Zapater A, Targa A, Mediano O, Masa JF, Masdeu MJ, Minguez O, Aguilà M, Barbé F, Sánchez-de-la-Torre M. Association of Obstructive Sleep Apnea with the Aging Process. Ann Am Thorac Soc. 2021 Sep;18(9):1540-1547.
Reorganizing the respiratory high dependency unit for pandemics.
Referencia: Masa JF, Patout M, Scala R, Winck JC. Reorganizing the respiratory high dependency unit for pandemics. Expert Rev Respir Med. 2021 Dec;15(12):1505-1515.
Summary of Recommendations and Key Points of the Consensus of Spanish Scientific Societies (SEPAR, SEMICYUC, SEMES. SECIP, SENEO, SEDAR, SENP) on the Use of Non-Invasive Ventilation and High-Flow Oxygen Therapy with Nasal Cannulas in Adult, Pediatric, and Neonatal Patients With Severe Acute Respiratory Failure.
Referencia: Luján M, Peñuelas Ó, Cinesi Gómez C, García-Salido A, Moreno Hernando J, Romero Berrocal A, Gutiérrez Ibarluzea I, Masa Jiménez JF, Mas A, Carratalá Perales JM, Gaboli M, Concheiro Guisán A, García Fernández J, Escámez J, Parrilla Parrilla J, Farrero Muñoz E, González M, Heili-Frades SB, Sánchez Quiroga MÁ, Rialp Cervera G, Hernández G, Sánchez Torres A, Uña R, Ferrando Ortolà C, Ferrer Monreal M, Egea Santaolalla C. Summary of Recommendations and Key Points of the Consensus of Spanish Scientific Societies (SEPAR, SEMICYUC, SEMES; SECIP, SENEO, SEDAR, SENP) on the Use of Non-Invasive Ventilation and High-Flow Oxygen Therapy with Nasal Cannulas in Adult, Pediatric, and Neonatal Patients With Severe Acute Respiratory Failure. Arch Bronconeumol (Engl Ed). 2021 Jun;57(6):415-427.
Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia: a systematic review and individual participant data meta-analysis.
Referencia: Lebret M, Léotard A, Pépin JL, Windisch W, Ekkernkamp E, Pallero M, Sánchez- Quiroga MÁ, Hart N, Kelly JL, Patout M, Funk GC, Duiverman ML, Masa JF, Simonds A, Murphy PB, Wijkstra PJ, Dreher M, Storre J, Khouri C, Borel JC. Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia: a systematic review and individual participant data meta-analysis. Thorax. 2021 Nov;76(11):1108-1116.
Abdominal obesity and myocardial infarction risk - We demonstrate the anthropometric and mathematical reasons that justify the association bias of the waist-to-hip ratio.
Referencia: Martín Castellanos Á, Martín Castellanos P, Martín E, Barca Durán FJ. Abdominal obesity and myocardial infarction risk - We demonstrate the anthropometric and mathematical reasons that justify the association bias of the waist-to-hip ratio. Nutr Hosp. 2021 Jun 10;38(3):502-510.
Abdominal obesity and myocardial infarction risk - We demonstrate the anthropometric and mathematical reasons that justify the association bias of the waist-to-hip ratio.
Referencia: Martín Castellanos Á, Martín Castellanos P, Martín E, Barca Durán FJ. Abdominal obesity and myocardial infarction risk - We demonstrate the anthropometric and mathematical reasons that justify the association bias of the waist-to-hip ratio. Nutr Hosp. 2021 Jun 10;38(3):502-510.
Forum COPD working group consensus on the diagnosis, treatment and follow-up of COPD.
Referencia: López-Campos JL, Calle Rubio M, Izquierdo Alonso JL, Fernández-Villar A, Abascal-Bolado B, Alcázar B, García-Río F, Peces-Barba G, Serra Batlles J, Martínez Garcerán JJ, Riesco Miranda JA, Figueira-Gonçalves JM, Soler-Cataluña JJ, Temprano M, Ortega Ruiz F, Santos Pérez S, Álvarez Martínez CJ. Forum COPD working group consensus on the diagnosis, treatment and follow-up of COPD. Arch Bronconeumol. 2021 Sep;57(9):596-599.
Forum COPD Working Group Consensus on the Diagnosis, Treatment and Follow-Up of COPD.
Referencia: López-Campos JL, Calle Rubio M, Izquierdo Alonso JL, Fernández-Villar A, Abascal-Bolado B, Alcázar B, García-Río F, Peces-Barba G, Serra Batlles J, Martínez Garcerán JJ, Riesco Miranda JA, Figueira-Gonçalves JM, Soler-Cataluña JJ, Temprano M, Ortega Ruiz F, Santos Pérez S, Álvarez Martínez CJ. Forum COPD Working Group Consensus on the Diagnosis, Treatment and Follow-Up of COPD. Arch Bronconeumol (Engl Ed). 2021 Jan 27:S0300-2896(21)00023-5.
Certified Smoking Cessation Units in Spain: High Potential for Detection of Undiagnosed Chronic Obstructive Pulmonary Disease and Profile of Newly Diagnosed Cases.
Referencia: Riesco-Miranda JA, Solano-Reina S, Rábade-Castedo C, de Granda-Orive JI, Pastor-Esplá E, García-Rueda M, Callejas-Gonzalez FJ, Azpeitia-Anadón Á, Mas S, Jiménez-Ruiz CA. Certified Smoking Cessation Units in Spain: High Potential for Detection of Undiagnosed Chronic Obstructive Pulmonary Disease and Profile of Newly Diagnosed Cases. Int J Chron Obstruct Pulmon Dis. 2021 Feb 25;16:443-450.
Balneotherapy year in review 2021: focus on the mechanisms of action of balneotherapy in rheumatic diseases
Referencia: Cheleschi, S., Tenti, S., Seccafico, I.,..Fioravanti, A., Ortega, E..Balneotherapy year in review 2021: focus on the mechanisms of action of balneotherapy in rheumatic diseases.Environ Sci Pollut Res Int, 2021 29(6):8054-8073.2021
Differential Health Effects on Inflammatory, Immunological and Stress Parameters in Professional Soccer Players and Sedentary Individuals after Consuming a Synbiotic. A Triple-Blinded, Randomized, Placebo-Controlled Pilot Study.
Referencia: Quero CD, Manonelles P, Fernández M, Abellán-Aynés O, López-Plaza D, Andreu-Caravaca L, Hinchado MD, Gálvez I, Ortega E.Differential Health Effects on Inflammatory, Immunological and Stress Parameters in Professional Soccer Players and Sedentary Individuals after Consuming a Synbiotic. A Triple-Blinded, Randomized, Placebo-Controlled Pilot Study..Nutrients.2021
Referencia: Maraver F, Armijo F, Fernandez-Toran MA, Armijo O, Ejeda JM, Vazquez I, Corvillo I, Torres-Piles S.Peloids as Thermotherapeutic Agents..Int J Environ Res Public Health.2021
Health-related quality of life in diabetes mellitus patients in primary health care
Referencia: Gálvez Galán I, Cáceres León MC, Guerrero-Martín J, López Jurado CF, Durán- Gómez N. Health-related quality of life in diabetes mellitus patients in primary health care. Enferm Clin (Engl Ed). 2021 Sep-Oct;31(5):313-322.
Routine assessment of kidney urea clearance, dialysis dose and protein catabolic rate in the once- weekly haemodialysis regimen.
Referencia: Casino FG, Deira J, Suárez MA, Aguilar J, Basile C. Routine assessment of kidney urea clearance, dialysis dose and protein catabolic rate in the once- weekly haemodialysis regimen. J Nephrol. 2021 Dec;34(6):2009-2015.
Relevance of NR1I2 variants on carbamazepine therapy in Mexican Mestizos with epilepsy at a tertiary-care hospital.
Referencia: Fricke-Galindo I, Jung-Cook H, Martínez-Juárez IE, Monroy-Jaramillo N, Ortega-Vázquez A, Rojas-Tomé IS, Dorado P, Peñas-Lledó E, Llerena A, López-López M. Relevance of NR1I2 variants on carbamazepine therapy in Mexican Mestizos with epilepsy at a tertiary-care hospital. Pharmacogenomics. 2021 Oct;22(15):983-996.
Detection of alcohol use disorders using the camouflaged CAGE questionnaire in three population groups.
Referencia: Zamora-Rodríguez FJ, Tolosa-Gutiérrez L, Sánchez-Autet M, Arranz B, Gónzález-Martínez I, Benítez-Vega C, Garriga M, Sánchez-Waisen Hernández MR, Guisado-Macías JA, Vaz-Leal FJ. Detection of alcohol use disorders using the camouflaged CAGE questionnaire in three population groups. Adicciones. 2021 Mar 31;33(2):121-136.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update.
Referencia: Karnes JH, Rettie AE, Somogyi AA, Huddart R, Fohner AE, Formea CM, Ta Michael Lee M, Llerena A, Whirl-Carrillo M, Klein TE, Phillips EJ, Mintzer S, Gaedigk A, Caudle KE, Callaghan JT. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update. Clin Pharmacol Ther. 2021 Feb;109(2):302-309.
Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population.
Referencia: de Andrés F, Altamirano-Tinoco C, Ramírez-Roa R, Montes-Mondragón CF, Dorado P, Peñas-Lledó EM, LLerena A. Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population. Pharmacogenomics J. 2021 Apr;21(2):140-151.
Systematic review of the impact of drugs on diffuse interstitial lung disease associated with rheumatoid arthritis.
Referencia: Carrasco Cubero C, Chamizo Carmona E, Vela Casasempere P. Systematic review of the impact of drugs on diffuse interstitial lung disease associated with rheumatoid arthritis. Reumatol Clin (Engl Ed). 2021 Nov;17(9):504-513.
Systematic review of the impact of drugs on diffuse interstitial lung disease associated with rheumatoid arthritis.
Referencia: Rúa-Figueroa Fernández de Larrinoa Í, Carreira PE, Brito García N, Díaz Del Campo Fontecha P, Pego Reigosa JM, Gómez Puerta JA, Ortega-Castro R, Tejera Segura B, Aguado García JM, Torre Cisneros J, Valencia-Martín JL, Pereda CA, Nishishinya-Aquino MB, Otón Sánchez MT, Silva Fernández L, Maese Manzano J, Chamizo Carmona E, Correyero Plaza M. Recommendations for prevention of infection in systemic autoimmune rheumatic diseases. Reumatol Clin (Engl Ed). 2021 Jun 24:S1699-258X(21)00124-8.
Recommendations for prevention of infection in systemic autoimmune rheumatic diseases.
Referencia: Carrasco Cubero C, Chamizo Carmona E. Answer to the Letter to the Editor: Methotrexate in Interstitial Lung Disease Associated With Rheumatoid Arthritis. Reumatol Clin (Engl Ed). 2021 Feb 5:S1699-258X(20)30303-X.
Cardiovascular mortality and cardiovascular event rates in patients with inflammatory rheumatic diseases in the CARdiovascular in rheuMAtology (CARMA) prospective study-results at 5 years of follow-up.
Referencia: Martín-Martínez MA, Castañeda S, Sánchez-Alonso F, García-Gómez C, González- Juanatey C, Sánchez-Costa JT, Belmonte-López MA, Tornero-Molina J, Santos-Rey J, Sánchez González CO, Quesada E, Moreno-Gil MP, Cobo-Ibáñez T, Pinto-Tasnde JA, Babío-Herráez J, Bonilla G, Juan Mas A, Manero-Ruiz FJ, Romera-Baurés M, Bachiller-Corral J, Chamizo-Carmona E, Uriarte Ecenarro M, Barbadillo C, Fernández-Carballido C, Aurrecoechea E, Möller-Parrera I, Llorca J, González-Gay MA; CARMA Project Collaborative Group. Cardiovascular mortality and cardiovascular event rates in patients with inflammatory rheumatic diseases in the CARdiovascular in rheuMAtology (CARMA) prospective study-results at 5 years of follow-up. Rheumatology (Oxford). 2021 Jun 18;60(6):2906-2915.
[Prognostic importance of diagnosticated peripheral arterial disease through the ankle brachial index in spanish general population].
Referencia: Félix-Redondo FJ, Subirana I, Baena-Diez JM, Ramos R, Cancho B, Fernández- Bergés D, Robles NR. Importancia pronóstica de la enfermedad arterial periférica diagnosticada mediante el índice tobillo-brazo en población general española [Prognostic importance of diagnosticated peripheral arterial disease through the ankle brachial index in spanish general population]. Aten Primaria. 2020 Nov;52(9):627-636.
National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries.
Referencia: NCD Risk Factor Collaboration (NCD-RisC). National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries. Int J Epidemiol. 2020 Feb 1;49(1):173-192.
[Scenario and relevance of clinical research in the era of big data].
Referencia: Fernández-Bergés D, Lozano L, Félix-Redondo F.J. Scenario and relevance of clinical research in the era of big data. 2020. REC: CardioClinics. 55(2):62-64.
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants.
Referencia: NCD Risk Factor Collaboration (NCD-RisC). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. Lancet. 2020 Nov 7;396(10261):1511-1524.
Repositioning of the global epicentre of non-optimal cholesterol.
Referencia: NCD Risk Factor Collaboration (NCD-RisC). Repositioning of the global epicentre of non-optimal cholesterol. Nature. 2020 Jun;582(7810):73-77.
Real-world assessment of direct oral anticoagulants and left atrial appendage closure in complex clinical situations.
Referencia: López-Mínguez JR, Nogales-Asensio JM, González-Fernández R. Real-world assessment of direct oral anticoagulants and left atrial appendage closure in complex clinical situations. Rev Esp Cardiol (Engl Ed). 2020 Jan;73(1):4-7.
Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction.
Referencia: Fernández-Bergés D, Degano IR, Gonzalez Fernandez R, Subirana I, Vila J, Jiménez-Navarro M, Perez Fernandez S, Roqué M, Bayes-Genis A, Fernandez-Aviles F, Mayorga A, Bertomeu-Gonzalez V, Sanchis J, Rodríguez Esteban M, Sanchez- Hidalgo A, Sanchez-Insa E, Elorriaga A, Abu Assi E, Nuñez A, Garcia Ruiz JM, Morrondo Valdeolmillos P, Bosch-Portell D, Lekuona I, Carrillo-Lopez A, Zamora A, Vega-Hernandez B, Alameda Serrano J, Rubert C, Ruiz-Valdepeñas L, Quintas L, Rodríguez-Padial L, Vaquero J, Martinez Dolz L, Barrabes JA, Sanchez PL, Sionis A, Martí-Almor J, Elosua R, Lidon RM, Garcia-Dorado D, Marrugat J; ATHOS investigators. Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction. Open Heart. 2020 Aug;7(2):e001169.
Impacto de los factores de riesgo cardiovascular en la población extremeña: aportación de la cohorte HERMEX para una estrategia preventiva [Impact of cardiovascular risk factors in the Extremadura population: HERMEX cohort contributions for a preventive strategy].
Referencia: Félix-Redondo FJ, Lozano Mera L, Alvarez-Palacios Arrighi P, Grau Magana M, Ramírez-Romero JM, Fernández-Bergés D. Impacto de los factores de riesgo cardiovascular en la población extremeña: aportación de la cohorte HERMEX para una estrategia preventiva [Impact of cardiovascular risk factors in the Extremadura population: HERMEX cohort contributions for a preventive strategy]. Aten Primaria. 2020 Jan;52(1):3-13.
The Value of Transcranial Doppler Sonography in Hyperperfusion Syndrome after Carotid Artery Stenting: A Nationwide Prospective Study.
Referencia: Moniche F, Escudero-Martínez I, Mancha F, Tomasello A, Ribó M, Delgado-Acosta F, Ochoa JJ, Gil J, Gil R, González-Delgado M, Murias E, Luna A, Gil A, Mosteiro S, Fernández-Couto MD, Alarcón LF, Ramírez Moreno JM, Zamarro J, Parrilla G, Caniego JL, Zapata-Wainberg G, González-Mandly A, Heras JAL, López-Mesonero L, Ortega J, Arenillas JF, García E, Alcázar PP, Zapata-Arriaza E, de Albóniga- Chindurza A, Cabezas JA, Algaba P, Cayuela A, Montaner J, García AG. The Value of Transcranial Doppler Sonography in Hyperperfusion Syndrome after Carotid Artery Stenting: A Nationwide Prospective Study. J Stroke. 2020 May;22(2):254-257.
Association between self-perceived psychological stress and transitory ischaemic attack and minor stroke: A case-control study.
Referencia: Ramírez-Moreno JM, Muñoz Vega P, Espada S, Bartolomé Alberca S, Aguirre J, Peral D. Association between self-perceived psychological stress and transitory ischaemic attack and minor stroke: A case control study. Neurologia (Engl Ed). 2020 Oct;35(8):556-562.
Progression of carotid near-occlusion to complete occlusion: related factors and clinical implications.
Referencia: García-Pastor A, Gil-Núñez A, Ramírez-Moreno JM, González-Nafría N, Tejada J, Moniche F, Portilla Cuenca JC, Martínez-Sánchez P, Fuentes B, Gamero-García MÁ, Alonso de Leciñana M, Masjuan J, Cánovas D, Aladro Y, Parkhutik V, Lago A, De Arce AM, Usero-Ruiz M, Delgado-Mederos R, Pampliega A, Ximénez-Carrillo Á, Bártulos-Iglesias M, Castro-Reyes E. Progression of carotid near-occlusion to complete occlusion: related factors and clinical implications. J Neurointerv Surg. 2020 Dec;12(12):1180 1185.
Cardiovascular risk assessment after one-year acute ischemic stroke based on uric acid levels and renal dysfunction. A clinical study.
Referencia: Arévalo-Lorido JC, Carretero-Gómez J, Robles NR. Cardiovascular risk assessment after one-year acute ischemic stroke based on uric acid levels and renal dysfunction. A clinical study. Int J Neurosci. 2021 Jun;131(6):609-614.
Risk factors for non-diabetic renal disease in diabetic patients.
Referencia: Bermejo S, González E, López-Revuelta K, Ibernon M, López D, Martín-Gómez A, Garcia-Osuna R, Linares T, Díaz M, Martín N, Barros X, Marco H, Navarro MI, Esparza N, Elias S, Coloma A, Robles NR, Agraz I, Poch E, Rodas L, Lozano V, Fernández B, Hernández E, Martínez MI, Stanescu RI, Moirón JP, García N, Goicoechea M, Calero F, Bonet J, Galceran JM, Liaño F, Pascual J, Praga M, Fulladosa X, Soler MJ. Risk factors for non-diabetic renal disease in diabetic patients. Clin Kidney J. 2020 Jan 3;13(3):380-388.
Recommendations for the management of renal involvement in the tuberous sclerosis complex.
Referencia: Ariceta G, Buj MJ, Furlano M, Martínez V, Matamala A, Morales M, Robles NR, Sans L, Villacampa F, Torra R. Recommendations for the management of renal involvement in the tuberous sclerosis complex. Nefrologia (Engl Ed). 2020 Mar- Apr;40(2):142-151.
Referencia: Robles NR, Fici F, Ari Bakir E, Grassi G. Does established vascular kidney disease exist? J Clin Hypertens (Greenwich). 2020 Feb;22(2):296-298.
PAIT-Survey Follow-Up: Changes in Albuminuria in Hypertensive Diabetic Patients with Mild-Moderate Chronic Kidney Disease.
Referencia: Fici F, Ari Bakir E, Ilkay Yüce E, Kanuncu S, Makel W, Tarim BA, Robles NR. PAIT-Survey Follow-Up: Changes in Albuminuria in Hypertensive Diabetic Patients with Mild-Moderate Chronic Kidney Disease. High Blood Press Cardiovasc Prev. 2020 Feb;27(1):43-49.
[Mental health in epidemics: A perspective from the Spanish Primary Health Care].
Referencia: Buitrago Ramírez F, Ciurana Misol R, Fernández Alonso MDC, Tizón García JL; Grupo de Salud Mental del PAPPS. Salud mental en epidemias: una perspectiva desde la Atención Primaria de Salud española [Mental health in epidemics: A perspective from the Spanish Primary Health Care]. Aten Primaria. 2020 Nov;52 Suppl 2(Suppl 2):93-113.
Prognostic importance of diagnosticated peripheral arterial disease through the ankle brachial index in spanish general population.
Referencia: Félix-Redondo FJ, Subirana I, Baena-Diez JM, Ramos R, Cancho B, Fernández- Bergés D, Robles NR. Importancia pronóstica de la enfermedad arterial periférica diagnosticada mediante el índice tobillo brazo en población general española [Prognostic importance of diagnosticated peripheral arterial disease through the ankle brachial index in spanish general population]. Aten Primaria. 2020 Nov;52(9):627-636.
Estudio ISCHEMIA: ¿una victoria del tratamiento conservador en la enfermedad coronaria estable?.
Referencia: Consuegra-Sánchez L, Fernández-Bergés D, López-Palop R. Estudio ISCHEMIA: ¿una victoria del tratamiento conservador en la enfermedad coronaria estable?. 2020. REC:Interv Cardiol. 2:306.
Toxicity of Necrostatin-1 in Parkinson´s Disease Models.
Referencia: Alegre-Cortés E, Muriel-González A, Canales-Cortés S, Uribe-Carretero E, Martínez-Chacón G, Aiastui A, López de Munain A, Niso-Santano M, Gonzalez-Polo RA, Fuentes JM, Yakhine-Diop SMS. Toxicity of Necrostatin-1 in Parkinson´s Disease Models. Antioxidants (Basel). 2020 Jun 15;9(6):524.
Depressed Mood after Stroke: Predictive Factors at Six Months Follow-Up.
Referencia: López-Espuela F, Roncero-Martín R, Canal-Macías ML, Moran JM, Vera V, Gomez- Luque A, Lendinez-Mesa A, Pedrera-Zamorano JD, Casado-Naranjo I, Lavado-García J. Depressed Mood after Stroke: Predictive Factors at Six Months Follow-Up. Int J Environ Res Public Health. 2020 Dec 20;17(24):9542.
Will neurological care change over the next 5 years due to the COVID-19 pandemic? Key informant consensus survey.
Referencia: Matías-Guiu J, Matias-Guiu JA, Alvarez-Sabin J, Ramon Ara J, Arenillas J, Casado-Naranjo I, Castellanos M, Jimenez-Hernandez MD, Lainez-Andres JM, Moral E, Morales A, Rodriguez Antigüedad A, Segura T, Serrano-Castro P, Diez-Tejedor E. Will neurological care change over the next 5 years due to the COVID-19 pandemic? Key informant consensus survey. Neurologia (Engl Ed). 2020 May;35(4):252-257.
Animal models used to study direct peripheral nerve repair: a systematic review.
Referencia: Vela FJ, Martínez-Chacón G, Ballestín A, Campos JL, Sánchez-Margallo FM, Abellán E. Animal models used to study direct peripheral nerve repair: a systematic review. Neural Regen Res. 2020 Mar;15(3):491-502.
Metabolic alterations in plasma from patients with familial and idiopathic Parkinson´s disease.
Referencia: Yakhine-Diop SMS, Morales-García JA, Niso-Santano M, González-Polo RA, Uribe- Carretero E, Martinez-Chacon G, Durand S, Maiuri MC, Aiastui A, Zulaica M, Ruíz- Martínez J, López de Munain A, Pérez-Tur J, Pérez-Castillo A, Kroemer G, Bravo- San Pedro JM, Fuentes JM. Metabolic alterations in plasma from patients with familial and idiopathic Parkinson´s disease. Aging (Albany NY). 2020 Sep 9;12(17):16690-16708.
Impact of PLA/Mg films degradation on surface physical properties and biofilm survival.
Referencia: Fernández-Calderón MC, Romero-Guzmán D, Ferrández-Montero A, Pérez-Giraldo C, González-Carrasco JL, Lieblich M, Benavente R, Ferrari B, González-Martín ML, Gallardo-Moreno AM. Impact of PLA/Mg films degradation on surface physical properties and biofilm survival. Colloids Surf B Biointerfaces. 2020 Jan 1;185:110617.
The role of magnesium in biomaterials related infections.
Referencia: Luque-Agudo V, Fernández-Calderón MC, Pacha-Olivenza MA, Pérez-Giraldo C, Gallardo-Moreno AM, González-Martín ML. The role of magnesium in biomaterials related infections. Colloids Surf B Biointerfaces. 2020 Jul;191:110996.
Chemical Profile and Antibacterial Activity of a Novel Spanish Propolis with New Polyphenols also Found in Olive Oil and High Amounts of Flavonoids.
Referencia: Fernández-Calderón MC, Navarro-Pérez ML, Blanco-Roca MT, Gómez-Navia C, Pérez-Giraldo C, Vadillo Rodríguez V. Chemical Profile and Antibacterial Activity of a Novel Spanish Propolis with New Polyphenols also Found in Olive Oil and High Amounts of Flavonoids. Molecules. 2020 Jul 22;25(15):3318.
Efficacy of laser shock processing of biodegradable Mg and Mg-1Zn alloy on their in vitro corrosion and bacterial response.
Referencia: Pacha-Olivenza MA, Galván JC, Porro JA, Lieblich M, Díaz M, Angulo I, Cordovilla F, García-Galván FR, Fernández-Calderón MC, González-Martín ML, González-Carrasco JL, Ocaña JL. Efficacy of laser shock processing of biodegradable Mg and Mg-1Zn alloy on their in vitro corrosion and bacterial response. Surface and Coatings Technology. 2020; 384, 125320.
Referencia: Lenis JA, Rico P, Ribelles JLG, Pacha-Olivenza MA, González-Martín ML, Bolívar FJ. Structure, morphology, adhesion and in vitro biological evaluation of antibacterial multi-layer HA-Ag/SiO2/TiN/Ti coatings obtained by RF magnetron sputtering for biomedical applications. Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111268.
The role of magnesium in biomaterials related infections.
Referencia: Luque-Agudo V, Fernández-Calderón MC, Pacha-Olivenza MA, Pérez-Giraldo C, Gallardo-Moreno AM, González-Martín ML. The role of magnesium in biomaterials related infections. Colloids Surf B Biointerfaces. 2020 Jul;191:110996.
Chemical composition of explanted deteriorated nephrostomy polyurethane-catheters through X-ray photoelectron spectroscopy.
Referencia: Fernández M, Hierro M, Fernández L, Gallardo AM. Chemical composition of explanted deteriorated nephrostomy polyurethane-catheters through X-ray photoelectron spectroscopy. Materials Chemistry and Physics. 2020; 239(3):121979
Chemical Profile and Antibacterial Activity of a Novel Spanish Propolis with New Polyphenols also Found in Olive Oil and High Amounts of Flavonoids.
Referencia: Fernández-Calderón MC, Navarro-Pérez ML, Blanco-Roca MT, Gómez-Navia C, Pérez-Giraldo C, Vadillo Rodríguez V. Chemical Profile and Antibacterial Activity of a Novel Spanish Propolis with New Polyphenols also Found in Olive Oil and High Amounts of Flavonoids. Molecules. 2020 Jul 22;25(15):3318.
Mechanically Induced Bacterial Death Imaged in Real Time: A Simultaneous Nanoindentation and Fluorescence Microscopy Study.
Referencia: Del Valle A, Torra J, Bondia P, Tone CM, Pedraz P, Vadillo-Rodriguez V, Flors C. Mechanically Induced Bacterial Death Imaged in Real Time: A Simultaneous Nanoindentation and Fluorescence Microscopy Study. ACS Appl Mater Interfaces. 2020 Jul 15;12(28):31235-31241.
Alu retrotransposons modulate Nanog expression through dynamic changes in regional chromatin.
Referencia: González-Rico FJ, Vicente-García C, Fernández A, Muñoz-Santos D, Montoliu L, Morales-Hernández A, Merino JM, Román AC, Fernández-Salguero PM. Alu retrotransposons modulate Nanog expression through dynamic changes in regional chromatin conformation via aryl hydrocarbon receptor. Epigenetics Chromatin. 2020 Mar 14;13(1):15.
Melatonin modulates proliferation of pancreatic stellate cells through caspase-3 activation and changes in cyclin A and D expression.
Referencia: Estaras M, Peña FJ, Tapia JA, Fernandez-Bermejo M, Mateos JM, Vara D, Roncero V, Blanco G, Lopez D, Salido GM, Gonzalez A. Melatonin modulates proliferation of pancreatic stellate cells through caspase-3 activation and changes in cyclin A and D expression. J Physiol Biochem. 2020 May;76(2):345-355.
Confident Perception of Primary Care Physicians Correlates to the Attitude Toward Donation and Organ Transplantation: A Multicenter Study of Medical And Nursing Spanish Students.
Referencia: Martínez-Alarcón L, Ríos A, Gutiérrez PR, Gómez FJ, Santainés-Borredá E, Agras-Suarez MC, Iriarte J, Cañadas-De la Fuente GA, Herruzo R, Hurtado-Pardos B, Blanco G, Bárcena-Calvo C, Llorca JF, Perelló Campaner C, Asunsolo A, Arribas Marin JM, Sánchez P, Mayor-García S, Fernández A, Soto-Ruíz MN, de Jesús MT, Navalón JC, Lana A, Noguer CB, Fuentes L, Peña Amaro MP, Hernández JR, Jiménez- Herrera MF, Virseda J, Blanco-Sánchez R, Yelamos J, Calvo-Sánchez MD, Bondía JA, Prado Laguna MC, González-García A, Martínez-Rodríguez A, Bas-Sarmiento P, Faus- Gabandé F, Muiños-Álvarez A, Peyró Gregori L, Hernández-Martínez H, López-Navas AI, Parrilla P, Ramírez P. Confident Perception of Primary Care Physicians Correlates to the Attitude Toward Donation and Organ Transplantation: A Multicenter Study of Medical And Nursing Spanish Students. Transplant Proc. 2020 Mar;52(2):491-495.
Organ Donation Related With Attitude Toward the Law of Presumed Consent: Spanish University Medical and Nursing Students Study.
Referencia: Martínez-Alarcón L, Ríos A, Gutiérrez PR, Gómez FJ, Santainés-Borredá E, Agras-Suarez MC, Iriarte J, Cañadas-De la Fuente GA, Herruzo R, Hurtado-Pardos B, Blanco G, Bárcena-Calvo C, Llorca FJ, Perelló Campaner C, Asunsolo A, Arribas-Marin JM, Sánchez P, García-Mayor S, Fernández A, Soto-Ruíz MN, Teresa de Jesús M, Navalón JC, Lana A, Bertran-Noguer C, Fuentes L, Peña-Amaro MP, Hernández JR, Jiménez-Herrera MF, Virseda J, Blanco-Sánchez R, Yelamos J, Calvo- Sánchez MD, Bondía JA, Prado Laguna MC, González-García A, Martínez-Rodríguez A, Bas-Sarmiento P, Faus-Gabandé F, Muiños Álvarez A, Peyró-Gregori L, Hernández- Martínez H, López-Navas AI, Parrilla P, Ramírez P. Organ Donation Related With Attitude Toward the Law of Presumed Consent: Spanish University Medical and Nursing Students Study. Transplant Proc. 2020 Mar;52(2):439-442.
Pancreatic stellate cells exhibit adaptation to oxidative stress evoked by hypoxia. Biol Cell.112(10):280-299,
Referencia: Estaras M, Martinez-Morcillo S, García A, Martinez R, Estevez M, Perez-Lopez M, Miguez MP, Fernandez Bermejo M, Mateos JM, Vara D, Blanco G, Lopez D, Roncero V, Salido GM, Gonzalez A. Pancreatic stellate cells exhibit adaptation to oxidative stress evoked by hypoxia. Biol Cell. 2020 Oct;112(10):280-299.
Melatonin modulates red-ox state and decreases viability of rat pancreatic stellate cells.
Referencia: Gonzalez A, Estaras M, Martinez-Morcillo S, Martinez R, García A, Estévez M, Santofimia-Castaño P, Tapia JA, Moreno N, Pérez-López M, Míguez MP, Blanco- Fernández G, Lopez-Guerra D, Fernandez-Bermejo M, Mateos JM, Vara D, Roncero V, Salido GM. Melatonin modulates red-ox state and decreases viability of rat pancreatic stellate cells. Sci Rep. 2020 Apr 14;10(1):6352.
Side-to-side duodenojejunostomy after resection of third and fourth duodenal portions with pancreatic preservation
Referencia: Blanco-Fernández G, Rojas-Holguín A, De-Armas-Conde N, Gallarín-Salamanca I, López-Guerra D, Jaén Torrejimeno I. Side-to-side duodenojejunostomy after resection of third and fourth duodenal portions with pancreatic preservation. Updates Surg. 2020 Dec;72(4):1105-1113.
Distal pancreatectomy with multivisceral resection: A retrospective multicenter study - Case series.
Referencia: Ramia JM, Del Río-Martín JV, Blanco-Fernández G, Cantalejo-Díaz M, Rotellar- Sastre F, Sabater-Orti L, Carabias-Hernandez A, Manuel-Vázquez A, Hernández- Rivera PJ, Jaén-Torrejimeno I, Kalviainen-Mejia HK, Esteban-Gordillo S, Muñoz- Forner E, De la Plaza R, Longoria-Dubocq T, De Armas-Conde N, Pardo Sanchez F, Garcés-Albir M, Serradilla-Martín M. Distal pancreatectomy with multivisceral resection: A retrospective multicenter study - Case series. Int J Surg. 2020 Oct;82:123-129.
Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial.
Referencia: Sánchez-de-la-Torre M, Sánchez-de-la-Torre A, Bertran S, Abad J, Duran- Cantolla J, Cabriada V, Mediano O, Masdeu MJ, Alonso ML, Masa JF, Barceló A, de la Peña M, Mayos M, Coloma R, Montserrat JM, Chiner E, Perelló S, Rubinós G, Mínguez O, Pascual L, Cortijo A, Martínez D, Aldomà A, Dalmases M, McEvoy RD, Barbé F; Spanish Sleep Network. Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial. Lancet Respir Med. 2020 Apr;8(4):359-367.
The Effect of Sleep Apnea on Cardiovascular Events in Different Acute Coronary Syndrome Phenotypes.
Referencia: Zapater A, Sánchez-de-la-Torre M, Benítez ID, Targa A, Bertran S, Torres G, Aldomà A, De Batlle J, Abad J, Duran-Cantolla J, Cabriada-Nuño V, Mediano O, Masdeu MJ, Muñoz C, Masa JF, De la Peña M, Mayos M, Coloma R, Montserrat JM, Chiner E, Mínguez O, Pascual L, Cortijo A, Martínez D, Dalmases M, McEvoy RD, Barbé F, Sánchez-de-la-Torre A; Spanish Sleep Network. The Effect of Sleep Apnea on Cardiovascular Events in Different Acute Coronary Syndrome Phenotypes. Am J Respir Crit Care Med. 2020 Dec 15;202(12):1698-1706.
Intra- and Inter-Physician Agreement in Therapeutic Decision for Sleep Apnea Syndrome.
Referencia: Lugo VM, Torres M, Garmendia O, Suarez-Giron M, Ruiz C, Carmona C, Chiner E, Tarraubella N, Dalmases M, Pedro AM, Egea CJ, Abellana M, Mayos M, Monasterio C, Masa JF, Farré R, Montserrat JM. Intra- and Inter-Physician Agreement in Therapeutic Decision for Sleep Apnea Syndrome. Arch Bronconeumol (Engl Ed). 2020 Jan;56(1):18-22.
Weight Loss Interventions as Treatment of Obesity Hypoventilation Syndrome. A Systematic Review.
Referencia: Kakazu MT, Soghier I, Afshar M, Brozek JL, Wilson KC, Masa JF, Mokhlesi B. Weight Loss Interventions as Treatment of Obesity Hypoventilation Syndrome. A Systematic Review. Ann Am Thorac Soc. 2020 Apr;17(4):492-502.
The Role of Positive Airway Pressure Therapy in Adults with Obesity Hypoventilation Syndrome. A Systematic Review and Meta-Analysis.
Referencia: Afshar M, Brozek JL, Soghier I, Kakazu MT, Wilson KC, Masa JF, Mokhlesi B. The Role of Positive Airway Pressure Therapy in Adults with Obesity Hypoventilation Syndrome. A Systematic Review and Meta-Analysis. Ann Am Thorac Soc. 2020 Mar;17(3):344-360.
The Effect of Hospital Discharge with Empiric Noninvasive Ventilation on Mortality in Hospitalized Patients with Obesity Hypoventilation Syndrome. An Individual Patient Data Meta-Analysis.
Referencia: Mokhlesi B, Masa JF, Afshar M, Almadana Pacheco V, Berlowitz DJ, Borel JC, Budweiser S, Carrillo A, Castro-Añón O, Ferrer M, Gagnadoux F, Golpe R, Hart N, Howard ME, Murphy PB, Palm A, Perez de Llano LA, Piper AJ, Pépin JL, Priou P, Sánchez-Gómez JF, Soghier I, Tamae Kakazu M, Wilson KC. The Effect of Hospital Discharge with Empiric Noninvasive Ventilation on Mortality in Hospitalized Patients with Obesity Hypoventilation Syndrome. An Individual Patient Data Meta-Analysis. Ann Am Thorac Soc. 2020 May;17(5):627-637.
Clinical Practice Guideline Summary for Clinicians: Evaluation and Management of Obesity Hypoventilation Syndrome.
Referencia: Gómez de Terreros FJ, Cooksey JA, Sunwoo BY, Mokhlesi B, Masa JF, Ruminjo JK, Thomson CC. Clinical Practice Guideline Summary for Clinicians: Evaluation and Management of Obesity Hypoventilation Syndrome. Ann Am Thorac Soc. 2020 Jan;17(1):11-15.
Effectiveness of different treatments in obesity hypoventilation syndrome.
Referencia: Ramírez Molina VR, Masa Jiménez JF, Gómez de Terreros Caro FJ, Corral Peñafiel J. Effectiveness of different treatments in obesity hypoventilation syndrome. Pulmonology. 2020 Nov-Dec;26(6):370-377.
Proangiogenic factor midkine is increased in melanoma patients with sleep apnea and induces tumor cell proliferation.
Referencia: Cubillos-Zapata C, Martínez-García MÁ, Díaz-García E, Toledano V, Campos- Rodríguez F, Sánchez-de-la-Torre M, Nagore E, Martorell-Calatayud A, Hernández Blasco L, Pastor E, Abad Capa J, Montserrat JM, Cabriada-Nuño V, Cano-Pumarega I, Corral-Peñafiel J, Arias E, Mediano O, Somoza-González M, Dalmau-Arias J, Almendros I, Farré R, López-Collazo E, Gozal D, García Río F; Spanish Sleep Network. Proangiogenic factor midkine is increased in melanoma patients with sleep apnea and induces tumor cell proliferation. FASEB J. 2020 Dec;34(12):16179-16190.
Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial.
Referencia: Sánchez-de-la-Torre M, Sánchez-de-la-Torre A, Bertran S, Abad J, Duran- Cantolla J, Cabriada V, Mediano O, Masdeu MJ, Alonso ML, Masa JF, Barceló A, de la Peña M, Mayos M, Coloma R, Montserrat JM, Chiner E, Perelló S, Rubinós G, Mínguez O, Pascual L, Cortijo A, Martínez D, Aldomà A, Dalmases M, McEvoy RD, Barbé F; Spanish Sleep Network. Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial. Lancet Respir Med. 2020 Apr;8(4):359-367.
The Effect of Sleep Apnea on Cardiovascular Events in Different Acute Coronary Syndrome Phenotypes.
Referencia: Zapater A, Sánchez-de-la-Torre M, Benítez ID, Targa A, Bertran S, Torres G, Aldomà A, De Batlle J, Abad J, Duran-Cantolla J, Cabriada-Nuño V, Mediano O, Masdeu MJ, Muñoz C, Masa JF, De la Peña M, Mayos M, Coloma R, Montserrat JM, Chiner E, Mínguez O, Pascual L, Cortijo A, Martínez D, Dalmases M, McEvoy RD, Barbé F, Sánchez-de-la-Torre A; Spanish Sleep Network. The Effect of Sleep Apnea on Cardiovascular Events in Different Acute Coronary Syndrome Phenotypes. Am J Respir Crit Care Med. 2020 Dec 15;202(12):1698-1706.
Intra- and Inter-Physician Agreement in Therapeutic Decision for Sleep Apnea Syndrome.
Referencia: Lugo VM, Torres M, Garmendia O, Suarez-Giron M, Ruiz C, Carmona C, Chiner E, Tarraubella N, Dalmases M, Pedro AM, Egea CJ, Abellana M, Mayos M, Monasterio C, Masa JF, Farré R, Montserrat JM. Intra- and Inter-Physician Agreement in Therapeutic Decision for Sleep Apnea Syndrome. Arch Bronconeumol (Engl Ed). 2020 Jan;56(1):18-22.
Weight Loss Interventions as Treatment of Obesity Hypoventilation Syndrome. A Systematic Review.
Referencia: Kakazu MT, Soghier I, Afshar M, Brozek JL, Wilson KC, Masa JF, Mokhlesi B. Weight Loss Interventions as Treatment of Obesity Hypoventilation Syndrome. A Systematic Review. Ann Am Thorac Soc. 2020 Apr;17(4):492-502.
The Role of Positive Airway Pressure Therapy in Adults with Obesity Hypoventilation Syndrome. A Systematic Review and Meta-Analysis.
Referencia: Afshar M, Brozek JL, Soghier I, Kakazu MT, Wilson KC, Masa JF, Mokhlesi B. The Role of Positive Airway Pressure Therapy in Adults with Obesity Hypoventilation Syndrome. A Systematic Review and Meta-Analysis. Ann Am Thorac Soc. 2020 Mar;17(3):344-360.
Influence of obesity and exercise on β2-adrenergic-mediated anti-inflammatory effects in peritoneal murine macrophages.
Referencia: Martín-Cordero L, Gálvez I, Hinchado MD, Ortega E. Influence of Obesity and Exercise on β2-Adrenergic Mediated Anti-Inflammatory Effects in Peritoneal Murine Macrophages. Biomedicines. 2020 Nov 30;8(12):556.
The Effect of Hospital Discharge with Empiric Noninvasive Ventilation on Mortality in Hospitalized Patients with Obesity Hypoventilation Syndrome. An Individual Patient Data Meta-Analysis.
Referencia: Mokhlesi B, Masa JF, Afshar M, Almadana Pacheco V, Berlowitz DJ, Borel JC, Budweiser S, Carrillo A, Castro-Añón O, Ferrer M, Gagnadoux F, Golpe R, Hart N, Howard ME, Murphy PB, Palm A, Perez de Llano LA, Piper AJ, Pépin JL, Priou P, Sánchez-Gómez JF, Soghier I, Tamae Kakazu M, Wilson KC. The Effect of Hospital Discharge with Empiric Noninvasive Ventilation on Mortality in Hospitalized Patients with Obesity Hypoventilation Syndrome. An Individual Patient Data Meta-Analysis. Ann Am Thorac Soc. 2020 May;17(5):627-637.
Effect of mud-bath therapy on the innate/inflammatory responses in elderly patients with osteoarthritis: a discussion of recent results and a pilot study on the role of the innate function of monocytes.
Referencia: Gálvez I, Torres-Piles S, Ortega E. Effect of mud-bath therapy on the innate/inflammatory responses in elderly patients with osteoarthritis: a discussion of recent results and a pilot study on the role of the innate function of monocytes. Int J Biometeorol. 2020 Jun;64(6):927-935.
Clinical Practice Guideline Summary for Clinicians: Evaluation and Management of Obesity Hypoventilation Syndrome.
Referencia: Gómez de Terreros FJ, Cooksey JA, Sunwoo BY, Mokhlesi B, Masa JF, Ruminjo JK, Thomson CC. Clinical Practice Guideline Summary for Clinicians: Evaluation and Management of Obesity Hypoventilation Syndrome. Ann Am Thorac Soc. 2020 Jan;17(1):11-15.
β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise.
Referencia: Gálvez I, Martín-Cordero L, Hinchado MD, Ortega E. β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Circulating Monocytes: Influence of Obesity and Exercise. Nutrients. 2020 May 16;12(5):1438.
Effectiveness of different treatments in obesity hypoventilation syndrome.
Referencia: Ramírez Molina VR, Masa Jiménez JF, Gómez de Terreros Caro FJ, Corral Peñafiel J. Effectiveness of different treatments in obesity hypoventilation syndrome. Pulmonology. 2020 Nov-Dec;26(6):370-377.
Probiotics, prebiotics and synbiotics: useful for athletes and active individuals? A systematic review.
Referencia: Calero CDQ, Rincón EO, Marqueta PM. Probiotics, prebiotics and synbiotics: useful for athletes and active individuals? A systematic review. Benef Microbes. 2020 Mar 27;11(2):135-149.
Proangiogenic factor midkine is increased in melanoma patients with sleep apnea and induces tumor cell proliferation.
Referencia: Cubillos-Zapata C, Martínez-García MÁ, Díaz-García E, Toledano V, Campos- Rodríguez F, Sánchez-de-la-Torre M, Nagore E, Martorell-Calatayud A, Hernández Blasco L, Pastor E, Abad Capa J, Montserrat JM, Cabriada-Nuño V, Cano-Pumarega I, Corral-Peñafiel J, Arias E, Mediano O, Somoza-González M, Dalmau-Arias J, Almendros I, Farré R, López-Collazo E, Gozal D, García Río F; Spanish Sleep Network. Proangiogenic factor midkine is increased in melanoma patients with sleep apnea and induces tumor cell proliferation. FASEB J. 2020 Dec;34(12):16179-16190.
Obesity attenuates the effect of sleep apnea on active TGF-ß1 levels and tumor aggressiveness in patients with melanoma.
Referencia: Cubillos-Zapata C, Martínez-García MÁ, Díaz-García E, Jaureguizar A, Campos- Rodríguez F, Sánchez-de-la-Torre M, Nagore E, Martorell-Calatayud A, Blasco LH, Pastor E, Abad-Capa J, Montserrat JM, Cabriada-Nuño V, Cano-Pumarega I, Corral- Peñafiel J, Arias E, Mediano O, Somoza-González M, Dalmau-Arias J, Almendros I, Farré R, López-Collazo E, Gozal D, García Río F. Obesity attenuates the effect of sleep apnea on active TGF-ß1 levels and tumor aggressiveness in patients with melanoma. Sci Rep. 2020 Sep 23;10(1):15528.
CPAP titration failure is not equivalent to long-term CPAP treatment failure in patients with obesity hypoventilation syndrome: a case series.
Referencia: Lastra AC, Masa JF, Mokhlesi B. CPAP titration failure is not equivalent to long-term CPAP treatment failure in patients with obesity hypoventilation syndrome: a case series. J Clin Sleep Med. 2020 Nov 15;16(11):1975-1981.
A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Referencia: Hicks JK, Bishop JR, Gammal RS, Sangkuhl K, Bousman CA, Leeder JS, Llerena A, Mueller DJ, Ramsey LB, Scott SA, Skaar TC, Caudle KE, Klein TE, Gaedigk A. A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy. Clin Pharmacol Ther. 2020 Jan;107(1):50-52.
High prevalence of CYP2D6 ultrarapid metabolizers in a mestizo Colombian population in relation to Hispanic mestizo populations.
Referencia: Sarmiento A, Dorado P, Borbón A, de Andrés F, LLerena A; CEIBA Consortium of the Ibero American Network of Pharmacogenetics and Pharmacogenomics RIBEF. High prevalence of CYP2D6 ultrarapid metabolizers in a mestizo Colombian population in relation to Hispanic mestizo populations. Pharmacogenomics. 2020 Nov;21(17):1227-1236.
Clinical implementation of pharmacogenetics and personalized drug prescription based on e-health: the MedeA initiative.
Referencia: LLerena A, Peñas-LLedó E, de Andrés F, Mata-Martín C, Sánchez CL, Pijierro A, Cobaleda J. Clinical implementation of pharmacogenetics and personalized drug prescription based on e-health: the MedeA initiative. Drug Metab Pers Ther. 2020 Sep 1;35(3).
Pharmacogenetics and therapeutic drug monitoring of fluoxetine in a real-world setting: A PK/PD analysis of the influence of (non-)genetic factors.
Referencia: Magalhães P, Alves G, Fortuna A, Llerena A, Falcão A; Clinical Collaborators of the GnG-PK/PD AD Study. Pharmacogenetics and therapeutic drug monitoring of fluoxetine in a real-world setting: A PK/PD analysis of the influence of (non-)genetic factors. Exp Clin Psychopharmacol. 2020 Oct;28(5):589-600.
The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What´s next? An urgent clinical unmet need for patients.
Referencia: Taron M, Llerena A, Manolopoulos VG, Rodriguez-Antona C, Stankovic S, van Schaik RHN. The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What´s next? An urgent clinical unmet need for patients. Drug Metab Pers Ther. 2020 Nov 13;35(4).
Current Insights into Interethnic Variability in Testicular Cancers: Population Pharmacogenetics, Clinical Trials, Genetic Basis of Chemotherapy- Induced Toxicities and Molecular Signal Transduction.
Referencia: Vasistha A, Kothari R, Mishra A, De Andrés F, LLerena A, Nair S. Current Insights into Interethnic Variability in Testicular Cancers: Population Pharmacogenetics, Clinical Trials, Genetic Basis of Chemotherapy- Induced Toxicities and Molecular Signal Transduction. Curr Top Med Chem. 2020;20(20):1824-1838.
RIBEF Ibero-American Network of Pharmacogenetics and Pharmacogenomics. Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans.
Referencia: Rodrigues-Soares F, Peñas-Lledó EM, Tarazona-Santos E, Sosa-Macías M, Terán E, López-López M, Rodeiro I, Moya GE, Calzadilla LR, Ramírez-Roa R, Grazina M, Estévez-Carrizo FE, Barrantes R, LLerena A; RIBEF Ibero-American Network of Pharmacogenetics and Pharmacogenomics. Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans. Clin Pharmacol Ther. 2020 Jan;107(1):257-268.
Influence of genetic variants and antiepileptic drug co-treatment on lamotrigine plasma concentration in Mexican Mestizo patients with epilepsy.
Referencia: Ortega-Vázquez A, Fricke-Galindo I, Dorado P, Jung-Cook H, Martínez-Juárez IE, Monroy Jaramillo N, Rojas-Tomé IS, Peñas-Lledó E, Llerena A, López-López M. Influence of genetic variants and antiepileptic drug co-treatment on lamotrigine plasma concentration in Mexican Mestizo patients with epilepsy. Pharmacogenomics J. 2020 Dec;20(6):845-856.
Challenges and Opportunities for Clinical Pharmacogenetic Research Studies in Resource-limited Settings: Conclusions From the Council for International Organizations of Medical Sciences-Ibero-American Network of Pharmacogenetics and Pharmacogenomics Meeting.
Referencia: Peñas-LLedó E, Terán E, Sosa-Macías M, Galaviz-Hernández C, Gil JP, Nair S, Diwakar S, Hernández I, Lara-Riegos J, Ramírez-Roa R, Verde I, Tarazona-Santos E, Molina-Guarneros J, Moya G, Rägo L, LLerena A. Challenges and Opportunities for Clinical Pharmacogenetic Research Studies in Resource-limited Settings: Conclusions From the Council for International Organizations of Medical Sciences-Ibero-American Network of Pharmacogenetics and Pharmacogenomics Meeting. Clin Ther. 2020 Aug;42(8):1595-1610.e5.
Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics, and clinical outcomes: GnG-PK/PD-AD study.
Referencia: Magalhães P, Alves G, Fortuna A, Llerena A, Falcão A. Real-world clinical characterization of subjects with depression treated with antidepressant drugs focused on (non-)genetic factors, pharmacokinetics, and clinical outcomes: GnG-PK/PD-AD study. Exp Clin Psychopharmacol. 2020 Apr;28(2):202-215.
Pharmacogenomics education in medical and pharmacy schools: conclusions of a global survey.
Referencia: Karas Kuželički N, Prodan Žitnik I, Gurwitz D, Llerena A, Cascorbi I, Siest S, Simmaco M, Ansari M, Pazzagli M, Di Resta C, Brandslund I, Schwab M, Vermeersch P, Lunshof JE, Dedoussis G, Flordellis CS, Fuhr U, Stingl JC, van Schaik RH, Manolopoulos VG, Marc J; Pharmacogenomics Education Working Group (PGxEWG); European Society of Pharmacogenomics and Personalized Therapy (ESPT). Pharmacogenomics education in medical and pharmacy schools: conclusions of a global survey. Pharmacogenomics. 2019 Jun;20(9):643-657.
4th ESPT summer school: precision medicine and personalised health.
Referencia: Mlakar V, Marc J, Manolopoulos VG, Cascorbi I, Stanković S, Llerena A, Simmaco M, Visvikis Siest S, Amstutz U, Sipeky C, Meyer UA, Meier-Abt P, van Schaik RH, Ansari M. 4th ESPT summer school: precision medicine and personalised health. Pharmacogenomics. 2019 May;20(7):471-474.
Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial.
Referencia: Gómez-Silva M, Piñeyro-Garza E, Vargas-Zapata R, Gamino-Peña ME, León-García A, de León MB, Llerena A, León-Cachón RBR. Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial. Sci Rep. 2019 Nov 28;9(1):17833.
Frequency of CYP2C9 (*2, *3 and IVS8-109A>T) allelic variants, and their clinical implications, among Mexican patients with diabetes mellitus type 2 undergoing treatment with glibenclamide and metformin.
Referencia: Cuautle-Rodríguez P, Rodríguez-Rivera N, De Andrés F, Castillo-Nájera F, Llerena A, Molina Guarneros JA. Frequency of CYP2C9 (*2, *3 and IVS8-109A>T) allelic variants, and their clinical implications, among Mexican patients with diabetes mellitus type 2 undergoing treatment with glibenclamide and metformin. Biomed Rep. 2019 May;10(5):283-295.
4th ESPT Conference:pharmacogenomics and personalized medicine-research progress and clinical implementation.
Referencia: Sipeky C, Llerena A, Manolopoulos VG, Pearson E, Mlakar V, Gozzo L, Simmaco M, Marchetti P, Re MD, Stankovic S, Meyer U, Cascorbi I, Ingelman-Sundberg M, Suarez-Kurtz G, Marc J, Katsila T, Paulmichl M, Nofziger C, Ansari M, Drago F,van Schaik RH. 4th ESPT Conference:pharmacogenomics and personalized medicine-research progress and clinical implementation. Pharmacogenomics. 2019 Oct;20(15):1063-1069.
[Performance of cardiovascular risk functions proposed for Spain in the Extremadura population of the HERMEX cohort].
Referencia: Félix-Redondo FJ, Subirana I, Lozano L, Buitrago F, Palomo L, Pérez JF, Fernández-Bergés D. Performance of cardiovascular risk functions proposed for Spain in the Extremadura population of the HERMEX cohort. 2019. REC: CardioClinics. 54(3):173-182.
Screening for cognitive impairment with the Montreal Cognitive Assessment in Spanish patients with minor stroke or transient ischaemic attack.
Referencia: Ramírez-Moreno JM, Bartolomé Alberca S, Muñoz Vega P, Guerrero Barona EJ. Screening for cognitive impairment with the Montreal Cognitive Assessment in Spanish patients with minor stroke or transient ischaemic attack. Neurologia (Engl Ed). 2022 Jan-Feb;37(1):38-44.
Infective endocarditis after transcatheter aortic valve implantation: Contributions of a single-centre experience on incidence and associated factors.
Referencia: Rodríguez-Vidigal FF, Nogales-Asensio JM, Calvo-Cano A, González-Fernández R, Martínez-Carapeto A, Gómez-Sanchez I, Bengla-Limpo B, Merchán-Herrera A, Nogales-Muñoz N, Vera-Tomé A, Muñoz-Sanz A, López-Mínguez JR. Infective endocarditis after transcatheter aortic valve implantation: Contributions of a single-centre experience on incidence and associated factors. Enferm Infecc Microbiol Clin (Engl Ed). 2019 Aug-Sep;37(7):428-434.
Validez y limitaciones de los métodos para medir la ingesta y la eliminación de sal [Validity and limitations of methods to measure the intake and elimination of salt].
Referencia: Jiménez Rodríguez A, Palomo Cobos L, Novalbos Ruiz JP, Rodríguez Martín A. Validez y limitaciones de los métodos para medir la ingesta y la eliminación de sal [Validity and limitations of methods to measure the intake and elimination of salt]. Aten Primaria. 2019 Dec;51(10):645-653.
Health-Related Quality of Life and Fatigue After Transient Ischemic Attack and Minor Stroke.
Referencia: Ramírez-Moreno JM, Muñoz-Vega P, Alberca SB, Peral-Pacheco D. Health-Related Quality of Life and Fatigue After Transient Ischemic Attack and Minor Stroke. J Stroke Cerebrovasc Dis. 2019 Feb;28(2):276 284.
Clinical Predictors of Hyperperfusion Syndrome Following Carotid Stenting: Results From a National Prospective Multicenter Study.
Referencia: González García A, Moniche F, Escudero-Martínez I, Mancha F, Tomasello A, Ribó M, Delgado-Acosta F, Ochoa JJ, de Las Heras JA, López-Mesonero L, González- Delgado M, Murias E, Gil J, Gil R, Zamarro J, Parrilla G, Mosteiro S, Fernández- Couto MD, Fernández de Alarcón L, Ramírez-Moreno JM, Luna A, Gil A, González- Mandly A, Caniego JL, Zapata-Wainberg G, García E, Alcázar PP, Ortega J, Arenillas JF, Algaba P, Zapata-Arriaza E, Alcalde-López J, de Albóniga-Chindurza A, Cayuela A, Montaner J. Clinical Predictors of Hyperperfusion Syndrome Following Carotid Stenting: Results From a National Prospective Multicenter Study. JACC Cardiovasc Interv. 2019 May 13;12(9):873-882.
The risk of recurrent stroke at 24 months in patients with symptomatic carotid near-occlusion: results from CAOS, a multicentre registry study.
Referencia: García-Pastor A, Gil-Núñez A, Ramírez-Moreno JM, González-Nafría N, Tejada J, Moniche F, Portilla Cuenca JC, Martínez-Sánchez P, Fuentes B, Gamero-García MÁ, Alonso de Leciñana M, Masjuán J, Cánovas-Verge D, Aladro Y, Parkhutik V, Lago- Martín A, de Arce-Borda AM, Usero-Ruíz M, Delgado Mederos R, Pampliega A, Ximenez-Carrillo Á, Bártulos-Iglesias M, Castro-Reyes E; Stroke Project of the Spanish Cerebrovascular Diseases Study Group. The risk of recurrent stroke at 24 months in patients with symptomatic carotid near-occlusion: results from CAOS, a multicentre registry study. Eur J Neurol. 2019 Nov;26(11):1391-1398.
[Needs of schoolchildren with type 1 diabetes in Extremadura: Family perceptions].
Referencia: Tomé Pérez Y, Barroso Martínez V, Félix-Redondo FJ, Tobajas Belvis L, Cordón Arroyo AM. Necesidades del alumnado con diabetes tipo 1 en Extremadura: percepción de las familias [Needs of schoolchildren with type 1 diabetes in Extremadura: Family perceptions]. An Pediatr (Engl Ed). 2019 Mar;90(3):173-179.
[Predictive variables of serious victims, critical or deceased in traffic accidents in Extremadura, Spain].
Referencia: Morales-Gabardino JA, Redondo-Lobato L, Buitrago-Ramírez F. Variables predictoras de víctimas graves, críticas o fallecidas en los accidentes de tráfico en Extremadura [Predictive variables of serious victims, critical or deceased in traffic accidents in Extremadura, Spain]. Rev Esp Salud Publica. 2019 Nov 15;93:e201911069.
Prevalence of diabetes and frequency of glycated haemoglobin monitoring in Extremadura (Spain) during 2012, 2013 and 2014: An observational study.
Referencia: Barquilla García A, Sánchez Vega J, Romero Vigara JC, Fernández L, Gamero Samino MJ, Buitrago F. Prevalence of diabetes and frequency of glycated haemoglobin monitoring in Extremadura (Spain) during 2012, 2013 and 2014: An observational study. Prim Care Diabetes. 2019 Aug;13(4):324-329.
Effectiveness of individual and group multicomponent interventions for smoking cessation in primary care: A quasi-experimental study.
Referencia: Suárez-Varela Úbeda JF, Rodríguez-Vázquez S, Ordóñez Barranco JA, Vega Caldera G, Pérez Alvárez PP, Buitrago F. Effectiveness of individual and group multicomponent interventions for smoking cessation in primary care: a quasi-experimental study. Fam Pract. 2019 Oct 8;36(5):627-633.
Rising rural body-mass index is the main driver of the global obesity epidemic in adults.
Referencia: NCD Risk Factor Collaboration (NCD-RisC). Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature. 2019 May;569(7755):260-264.
Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation.
Referencia: Mota-Zamorano S, González LM, Luna E, Fernández JJ, Gómez Á, Nieto-Fernández A, Robles NR, Gervasini G. Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation. PLoS One. 2019 Oct 17;14(10):e0224129.
Prognostic Role of Hyponatremia in Heart Failure Patients Depending on Renal Disease: Clinical Evidence.
Referencia: Arévalo-Lorido JC, Carretero-Gómez J, Robles NR, Llácer P, Carrera M, Suárez- Pedreira I, Álvarez-Rocha P, Manzano-Espinosa L, Cepeda-Rodrigo JM, Montero- Pérez-Barquero M; on behalf of the RICA Investigators Group. Prognostic Role of Hyponatremia in Heart Failure Patients Depending on Renal Disease: Clinical Evidence. Cardiology. 2019;144(1-2):1-8.
A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery.
Referencia: Ballestín A, Casado JG, Abellán E, Vela FJ, Campos JL, Martínez-Chacón G, Bote J, Blázquez R, Sánchez-Margallo FM. A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery. J Vis Exp. 2019 Nov 8;(153).
MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation.
Referencia: Martí-Fàbregas J, Medrano-Martorell S, Merino E, Prats-Sánchez L, Marín R, Delgado-Mederos R, Martínez-Domeño A, Camps-Renom P, Jiménez-Xarrié E, Zedde M, Gómez-Choco M, Lara L, Boix A, Calleja A, De Arce-Borda AM, Bravo Y, Fuentes B, Hernández-Pérez M, Cánovas D, Llull L, Zandio B, Freijo M, Casado-Naranjo I, Sanahuja J, Cocho D, Krupinski J, Rodríguez-Campello A, Palomeras E, De Felipe A, Serrano M, Zapata-Arriaza E, Zaragoza-Brunet J, Díaz-Maroto I, Fernández- Domínguez J, Lago A, Maestre J, Rodríguez-Yáñez M, Gich I; HERO study investigators. MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation. Neurology. 2019 May 21;92(21):e2432-e2443.
Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack.
Referencia: Martinez-Arroyo O, Gruevska A, Victor VM, González-Polo RA, Yakhine-Diop SMS, Fuentes JM, Esplugues JV, Blas-Garcia A, Apostolova N. Mitophagy in human astrocytes treated with the antiretroviral drug Efavirenz: Lack of evidence or evidence of the lack. Antiviral Res. 2019 Aug;168:36-50.
LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer´s disease brains.
Referencia: Mórotz GM, Glennon EB, Gomez-Suaga P, Lau DHW, Robinson ED, Sedlák É, Vagnoni A, Noble W, Miller CCJ. LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer´s disease brains. Acta Neuropathol Commun. 2019 May 8;7(1):73.
Natural Products in the Promotion of Healthspan and Longevity.
Referencia: Niso-Santano M, González-Polo RA, Paredes-Barquero M, Fuentes JM, Aschner M. Natural Products in the Promotion of Healthspan and Longevity. Clin Pharmacol Transl Med. 2019;3(1):149-151.
The paradigm of protein acetylation in Parkinson´s disease.
Referencia: Yakhine-Diop SMS, Martínez-Chacón G, Uribe-Carretero E, Niso-Santano M, González-Polo RA, Fuentes JM. The paradigm of protein acetylation in Parkinson´s disease. Neural Regen Res. 2019 Jun;14(6):975-976.
Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson´s Disease Patients.
Referencia: Yakhine-Diop SMS, Niso-Santano M, Rodríguez-Arribas M, Gómez-Sánchez R, Martínez-Chacón G, Uribe-Carretero E, Navarro-García JA, Ruiz-Hurtado G, Aiastui A, Cooper JM, López de Munaín A, Bravo-San Pedro JM, González-Polo RA, Fuentes JM. Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson´s Disease Patients. Mol Neurobiol. 2019 Apr;56(4):2466-2481.
Candida tropicalis biofilm formation and expression levels of the CTRG ALS-like genes in sessile cells.
Referencia: Galán-Ladero MÁ, Blanco-Blanco MT, Fernández-Calderón MC, Lucio L, Gutiérrez- Martín Y, Blanco MT, Pérez-Giraldo C. Candida tropicalis biofilm formation and expression levels of the CTRG ALS-like genes in sessile cells. Yeast. 2019 Feb;36(2):107-115.
Relevance of topographic parameters on the adhesion and proliferation of human gingival fibroblasts and oral bacterial strains.
Referencia: Pacha-Olivenza MÁ, Tejero R, Fernández-Calderón MC, Anitua E, Troya M, González-Martín ML. Relevance of Topographic Parameters on the Adhesion and Proliferation of Human Gingival Fibroblasts and Oral Bacterial Strains. Biomed Res Int. 2019 Feb 10;2019:8456342.
Force spectroscopy-based simultaneous topographical and mechanical characterization to study polymer-to-polymer interactions in coated alginate microspheres.
Referencia: Virumbrales-Muñoz M, Santos-Vizcaino E, Paz L, Gallardo-Moreno AM, Orive G, Hernandez RM, Doblaré M, Gonzalez-Martin ML, Fernández LJ, Pedraz JL, Ochoa I. Force spectroscopy-based simultaneous topographical and mechanical characterization to study polymer-to-polymer interactions in coated alginate microspheres. Sci Rep. 2019 Dec 27;9(1):20112.
Antibacterial hyaluronic acid/chitosan multilayers onto smooth and micropatterned titanium surfaces.
Referencia: Valverde A, Pérez-Álvarez L, Ruiz-Rubio L, Pacha Olivenza MA, García Blanco MB, Díaz-Fuentes M, Vilas Vilela JL. Antibacterial hyaluronic acid/chitosan multilayers onto smooth and micropatterned titanium surfaces. Carbohydr Polym. 2019 Mar 1;207:824-833.
Kinetic of Adhesion of S. epidermidis with Different EPS Production on Ti6Al4V Surfaces.
Referencia: Pacha-Olivenza MÁ, Rodríguez-Cano A, González-Martín ML, Gallardo-Moreno AM. Kinetic of Adhesion of S. epidermidis with Different EPS Production on Ti6Al4V Surfaces. Biomed Res Int. 2019 Nov 26;2019:1437806.
Relevance of topographic parameters on the adhesion and proliferation of human gingival fibroblasts and oral bacterial strains.
Referencia: Pacha-Olivenza MÁ, Tejero R, Fernández-Calderón MC, Anitua E, Troya M, González-Martín ML. Relevance of Topographic Parameters on the Adhesion and Proliferation of Human Gingival Fibroblasts and Oral Bacterial Strains. Biomed Res Int. 2019 Feb 10;2019:8456342.
Bactericidal effect of magnesium ions over planktonic and sessile Staphylococcus epidermidis and Escherichia coli.
Referencia: Rodríguez J, Pacha MA, González-Martín ML. Bactericidal effect of magnesium ions over planktonic and sessile Staphylococcus epidermidis and Escherichia coli. Materials Chemistry and Physics. 2019; 221, 342 - 348.
Melatonin induces reactive oxygen species generation and changes in glutathione levels and reduces viability in human pancreatic stellate cells.
Referencia: Estaras M, Moreno N, Santofimia-Castaño P, Martinez-Morcillo S, Roncero V, Blanco G, Lopez D, Fernandez-Bermejo M, Mateos JM, Iovanna JL, Salido GM, Gonzalez A. Melatonin induces reactive oxygen species generation and changes in glutathione levels and reduces viability in human pancreatic stellate cells. J Physiol Biochem. 2019 Jun;75(2):185-197.
Pattern of Relapse in Hepatic Hydatidosis: Analysis of 238 Cases in a Single Hospital.
Referencia: Jaén-Torrejimeno I, López-Guerra D, Prada-Villaverde A, Blanco-Fernández G. Pattern of Relapse in Hepatic Hydatidosis: Analysis of 238 Cases in a Single Hospital. J Gastrointest Surg. 2020 Feb;24(2):361-367.
The Impact of Culturing the Organ Preservation Fluid on Solid Organ Transplantation: A Prospective Multicenter Cohort Study
Referencia: Oriol I, Sabe N, Càmara J, Berbel D, Ballesteros MA, Escudero R, Lopez- Medrano F, Linares L, Len O, Silva JT, Oliver E, Soldevila L, Pérez-Recio S, Guillem LL, Camprubí D, LLadó L, Manonelles A, González Costello J, Domínguez MA, Fariñas MC, Lavid N, González-Rico C, Garcia-Cuello L, Arnaiz de Las Revillas F, Fortun J, Aguado JM, Jimenez-Romero C, Bodro M, Almela M, Paredes D, Moreno A, Pérez-Cameo C, Muñoz-Sanz A, Blanco-Fernández G, Cabo-González JA, García-López JL, Nuño E, Carratalà J. The Impact of Culturing the Organ Preservation Fluid on Solid Organ Transplantation: A Prospective Multicenter Cohort Study. Open Forum Infect Dis. 2019 Apr 26;6(6):ofz180.
A survey of Heads of Surgery and Residents on accessibility and employment in liver transplant teams in Spain
Referencia: Blanco Fernández G, Gómez Bravo MÁ, Briceño Delgado J, Valdivieso López A; Grupo Español de Trabajo sobre Trasplante Hepático; Grupo Español de Trabajo sobre Trasplante Hepático. A survey of Heads of Surgery and Residents on accessibility and employment in liver transplant teams in Spain. Cir Esp (Engl Ed). 2019 Dec;97(10):560-567.
Actualización en el manejo de sarcomas retroperitoneales y pévicos; el papel de la cirugía compartimental.
Referencia: Asencio JM, Fernandez JA, Blanco G, Muñoz C, Alvarez R, Fox B, Lozano A, Rodríguez M, Cantín S, Artigas V. Actualización en el manejo de sarcomas retroperitoneales y pévicos; el papel de la cirugía compartimental. Cir esp. 2019; 97(9):480-488
Postoperative bleeding and biliary leak after liver resection: A cohort study between two different fibrin sealant patches.
Referencia: López-Guerra D, Santos-Naharro J, Rojas-Holguín A, Jaen-Torrejimeno I, Prada- Villaverde A, Blanco Fernández G. Postoperative bleeding and biliary leak after liver resection: A cohort study between two different fibrin sealant patches. Sci Rep. 2019 Aug 19;9(1):12001.
Obesity affects β2 adrenergic regulation of the inflammatory profile and phenotype of circulating monocytes from exercised animals.
Referencia: Gálvez I, Martín-Cordero L, Hinchado MD, Álvarez-Barrientos A, Ortega E. Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and Phenotype of Circulating Monocytes from Exercised Animals. Nutrients. 2019 Nov 2;11(11):2630.
Anti-inflammatory effect of β2 adrenergic stimulation on circulating monocytes with a pro-inflammatory state in high-fat diet-induced obesity.
Referencia: Gálvez I, Martín-Cordero L, Hinchado MD, Álvarez-Barrientos A, Ortega E. Anti-inflammatory effect of β2 adrenergic stimulation on circulating monocytes with a pro-inflammatory state in high-fat diet-induced obesity. Brain Behav Immun. 2019 Aug;80:564-572.
Adrenergic regulation of macrophage-mediated innate/inflammatory responses in obesity and exercise in this condition: Role of β2 adrenergic receptors Endocrine, Metabolic and Immune Disorders.
Referencia: Ortega E, Gálvez I, Martín-Cordero L. Adrenergic Regulation of Macrophage- Mediated Innate/Inflammatory Responses in Obesity and Exercise in this Condition: Role of β2 Adrenergic Receptors. Endocr Metab Immune Disord Drug Targets. 2019;19(8):1089-1099.
β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Macrophages from Obese and Lean Mice: Effects of Exercise.
Referencia: Martín-Cordero L, Gálvez I, Hinchado MD, Ortega E. β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of Macrophages from Obese and Lean Mice: Effects of Exercise. Nutrients. 2019 Nov 9;11(11):2721.
Comprehensive management of obstructive sleep apnea by telemedicine: Clinical improvement and cost-effectiveness of a Virtual Sleep Unit. A randomized controlled trial.
Referencia: Lugo VM, Garmendia O, Suarez-Girón M, Torres M, Vázquez-Polo FJ, Negrín MA, Moraleda A, Roman M, Puig M, Ruiz C, Egea C, Masa JF, Farré R, Montserrat JM. Comprehensive management of obstructive sleep apnea by telemedicine: Clinical improvement and cost-effectiveness of a Virtual Sleep Unit. A randomized controlled trial. PLoS One. 2019 Oct 24;14(10):e0224069.
Noninvasive Ventilation versus CPAP as Initial Treatment of Obesity Hypoventilation Syndrome.
Referencia: Soghier I, Brożek JL, Afshar M, Tamae Kakazu M, Wilson KC, Masa JF, Mokhlesi B. Noninvasive Ventilation versus CPAP as Initial Treatment of Obesity Hypoventilation Syndrome. Ann Am Thorac Soc. 2019 Oct;16(10):1295-1303.
Good long- term adherence to continuous positive airway pressure therapy in patients with resistant hypertension and sleep apnea.
Referencia: Campos-Rodriguez F, Navarro-Soriano C, Reyes-Nuñez N, Torres G, Caballero-Eraso C, LloberesP,Diaz-Cambriles T, Somoza M, Masa JF, Gonzalez M, Mañas E,de la Peña M, Barbe F, Garcia-Rio F, Montserrat JM, Muriel A, Garcia-Ortega A, Selma MJ, Martinez-Garcia MA; on behalf the Spanish Sleep Network. Good long- term adherence to continuous positive airway pressure therapy in patients with resistant hypertension and sleep apnea. J Sleep Res. 2019 Oct;28(5):e12805.
Evaluation and Management of Obesity Hypoventilation Syndrome. An Official American Thoracic Society Clinical Practice Guideline.
Referencia: Mokhlesi B, Masa JF, Brozek JL, Gurubhagavatula I, Murphy PB, Piper AJ, Tulaimat A, Afshar M, Balachandran JS, Dweik RA, Grunstein RR, Hart N, Kaw R, Lorenzi-Filho G, Pamidi S, Patel BK, Patil SP, Pépin JL, Soghier I, Tamae Kakazu M, Teodorescu M. Evaluation and Management of Obesity Hypoventilation Syndrome. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2019 Aug 1;200(3):e6-e24.
Biomarker panel in sleep apnea patients after an acute coronary event.
Referencia: Bauça JM, Barcelo A, Fueyo L, Sanchís P, Pierola J, de la Peña M, Arqué M, Gómez C, Morell Garcia D, Sánchez-de-la-Torre A, Sánchez-de-la-Torre M, Abad J, Duran-Cantolla J, Mediano O, Masdeu MJ, Urrutia-Gajate A, Masa JF, Barbé F; Spanish Sleep Group. Biomarker panel in sleep apnea patients after an acute coronary event. Clin Biochem. 2019 Jun;68:24-29.
Prevalence, Characteristics, and Association of Obstructive Sleep Apnea with Blood Pressure Control in Patients with Resistant Hypertension.
Referencia: Sapiña-Beltrán E, Torres G, Benitez I, Fortuna-Gutiérrez AM, Márquez PP, Masa JF, Corral Peñafiel J, Drager LF, Cabrini M, Félez M, Vázquez S, Abad J, Lee CH, Aung AT, García-Río F, Casitas R, Sanchez-de-la-Torre M, Gaeta AM, Barbé F,Dalmases M. Prevalence, Characteristics, and Association of Obstructive Sleep Apnea with Blood Pressure Control in Patients with Resistant Hypertension. Ann Am Thorac Soc. 2019 Nov;16(11):1414-1421.
Factors associated with the changes from a resistant to a refractory phenotype in hypertensive patients: a Pragmatic Longitudinal Study.
Referencia: Navarro-Soriano C, Martínez-García MA, Torres G, Barbé F, Caballero-Eraso C, Lloberes P, Cambriles TD, Somoza M, Masa JF, González M, Mañas E, de la Peña M, García-Río F, Montserrat JM, Muriel A, Oscullo G, Olmos LF, García-Ortega A, Calhoun D, Campos-Rodriguez F; Spanish Sleep Network. Factors associated with the changes from a resistant to a refractory phenotype in hypertensive patients: a Pragmatic Longitudinal Study. Hypertens Res. 2019 Nov;42(11):1708-1715.
Effect of continuous positive airway pressure in patients with true refractory hypertension and sleep apnea: a post-hoc intention-to-treat analysis of the HIPARCO randomized clinical trial.
Referencia: Navarro-Soriano C, Martínez-García MA, Torres G, Barbé F, Caballero-Eraso C, Lloberes P, Diaz Cambriles T, Somoza M, Masa JF, González M, Mañas E, de la Peña M, García-Río F, Montserrat JM, Muriel A, Oscullo G, Feced Olmos L, García- Ortega A, Calhoun D, Campos-Rodriguez F; on behalf the Spanish Sleep Network. Effect of continuous positive airway pressure in patients with true refractory hypertension and sleep apnea: a post-hoc intention-to-treat analysis of the HIPARCO randomized clinical trial. J Hypertens. 2019 Jun;37(6):1269-1275.
Continuous Positive Airway Pressure Treatment Does not Reduce Uric Acid Levels in OSA Women.
Referencia: Campos-Rodriguez F, Reyes-Nuñez N, Queipo-Corona C, Sanchez-Armengol A, Jurado-Gamez B, Cordero-Guevara J, Troncoso MF, Abad-Fernandez A, Caballero- Rodriguez J, Martin-Romero M, Encabo-Motiño A, Sacristan-Bou L, Navarro-Esteva J, Somoza-Gonzalez M, Masa JF, Sanchez Quiroga MA, Jara-Chinarro B, Orosa-Bertol B, Martinez-Garcia MA; Spanish Sleep Network; Spanish Sleep Network is composed of the following individuals. Continuous Positive Airway Pressure Treatment Does not Reduce Uric Acid Levels in OSA Women. Arch Bronconeumol (Engl Ed). 2019 Apr;55(4):201-207.
Soluble PD-L1 is a potential biomarker of cutaneous melanoma aggressiveness and metastasis in obstructive sleep apnoea patients.
Referencia: Cubillos-Zapata C, Martínez-García MÁ, Campos-Rodríguez F, Sánchez de la Torre M, Nagore E, Martorell-Calatayud A, Hernández Blasco L, Chiner Vives E, Abad-Capa J, Montserrat JM, Cabriada-Nuño V, Cano-Pumarega I, Corral-Peñafiel J, Diaz-Cambriles T, Mediano O, Somoza González M, Dalmau-Arias J, Almendros I, Farré R, López-Collazo E, Gozal D, García-Río F; Spanish Sleep Network. Soluble PD-L1 is a potential biomarker of cutaneous melanoma aggressiveness and metastasis in obstructive sleep apnoea patients. Eur Respir J. 2019 Jan 31;53(2):1801298.
Pharmacogenetics of adverse reactions to antiepileptic drugs.
Referencia: Fricke-Galindo I, Jung-Cook H, LLerena A, López-López M. Pharmacogenetics of adverse reactions to antiepileptic drugs. Neurologia (Engl Ed). 2018 Apr;33(3):165-176.
Referencia: Fricke-Galindo I, LLerena A, Jung-Cook H, López-López M. Carbamazepine adverse drug reactions. Expert Rev Clin Pharmacol. 2018 Jul;11(7):705-718.
Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis.
Referencia: Bioque M, García-Portilla MAP, García-Rizo C, Cabrera B, Lobo A, González- Pinto A, Díaz-Caneja CM, Corripio I, Vieta E, Castro-Fornieles J, Bobes J, Gutiérrez-Fraile M, Rodriguez-Jimenez R, Mezquida G, Llerena A, Saiz-Ruiz J, Bernardo M; PEPs GROUP. Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis. Schizophr Res. 2018 Mar;193:188-196.
Siest Prize awarded to Alžběta Hlaváčková at the 9th Santorini Conference.
Referencia: LLerena A, Jahnke H. Gérard Siest Prize awarded to Alžběta Hlaváčková at the 9th Santorini Conference. Drug Metab Pers Ther. 2018 Dec 19;33(4):157.
New perspectives in personalised medicine for ethnicity in cancer: population pharmacogenomics and pharmacometrics.
Referencia: Nair S, LLerena A. New perspectives in personalised medicine for ethnicity in cancer: population pharmacogenomics and pharmacometrics. Drug Metab Pers Ther. 2018 Jun 27;33(2):61-64.
Genetic structure of pharmacogenetic biomarkers in Brazil inferred from a systematic review and population-based cohorts: a RIBEF/EPIGEN- Brazil initiative.
Referencia: Rodrigues-Soares F, Kehdy FSG, Sampaio-Coelho J, Andrade PXC, Céspedes-Garro C, Zolini C, Aquino MM, Barreto ML, Horta BL, Lima-Costa MF, Pereira AC, Llerena A, Tarazona-Santos E. Genetic structure of pharmacogenetic biomarkers in Brazil inferred from a systematic review and population-based cohorts: a RIBEF/EPIGEN- Brazil initiative. Pharmacogenomics J. 2018 Dec;18(6):749-759.
Impact of NTRK2, DRD2 and ACE polymorphisms on prolactin levels in antipsychotic-treated patients with first-episode psychosis.
Referencia: Gassó P, Mas S, Bioque M, Cabrera B, Lobo A, González-Pinto A, Díaz-Caneja CM, Corripio I, Vieta E, Castro-Fornieles J, Sarró S, Mané A, Sanjuan J, Llerena A, Lafuente A, Saiz-Ruiz J, Bernardo M; PEPs Group. Impact of NTRK2, DRD2 and ACE polymorphisms on prolactin levels in antipsychotic-treated patients with first-episode psychosis. J Psychopharmacol. 2018 Jun;32(6):702-710.
Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations.
Referencia: Bedada W, de Andrés F, Engidawork E, Hussein J, LLerena A, Aklillu E. Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations. Sci Rep. 2018 Aug 24;8(1):12726.
Interethnic Variability in CYP2D6, CYP2C9, and CYP2C19 Genes and Predicted Drug Metabolism Phenotypes Among 6060 Ibero- and Native Americans: RIBEF-CEIBA Consortium Report on Population Pharmacogenomics.
Referencia: Naranjo MG, Rodrigues-Soares F, Peñas-Lledó EM, Tarazona-Santos E, Fariñas H, Rodeiro I, Terán E, Grazina M, Moya GE, López-López M, Sarmiento AP, Calzadilla LR, Ramírez-Roa R, Ortiz-López R, Estévez-Carrizo FE, Sosa-Macías M, Barrantes R, LLerena A; CEIBA-Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics RIBEF. Interethnic Variability in CYP2D6, CYP2C9, and CYP2C19 Genes and Predicted Drug Metabolism Phenotypes Among 6060 Ibero- and Native Americans: RIBEF-CEIBA Consortium Report on Population Pharmacogenomics. OMICS. 2018 Sep;22(9):575-588.
A comparison of cystatin C concentrations between patients with chronic interstitial nephritis and glomerular diseases.
Referencia: Robles NR, Mena C, Chavez E, Bayo MA, Gonzalez Candia B, Cidoncha A, Lopez Gomez J, Cubero JJ. A comparison of cystatin C concentrations between patients with chronic interstitial nephritis and glomerular diseases. J Clin Lab Anal. 2018 Jan;32(1):e22166.
Trends in stroke hospitalisation rates in Extremadura between 2002 and 2014: Changing the notion of stroke as a disease of the elderly.
Referencia: Ramírez-Moreno JM, Felix-Redondo FJ, Fernández-Bergés D, Lozano-Mera L. Trends in stroke hospitalisation rates in Extremadura between 2002 and 2014: Changing the notion of stroke as a disease of the elderly. Neurologia (Engl Ed). 2018 Nov-Dec;33(9):561-569.
Association of Resting Heart Rate With Arterial Stiffness and Low-Grade Inflammation in Women With Systemic Lupus Erythematosus.
Referencia: Vargas-Hitos JA, Soriano-Maldonado A, Martínez-Bordonado J, Sánchez-Berná I, Fernández-Bergés D, Sabio JM. Association of Resting Heart Rate With Arterial Stiffness and Low-Grade Inflammation in Women With Systemic Lupus Erythematosus. Angiology. 2018 Sep;69(8):672-676.
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants.
Referencia: NCD Risk Factor Collaboration (NCD-RisC). Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants. Int J Epidemiol. 2018 Jun 1;47(3):872-883i.
Left Atrial Appendage Perforation Does Not Always Mean Pericardial Effusion.
Referencia: López-Mínguez JR, González-Fernández R, Nogales-Asensio JM, Bengla-Limpo B, Martínez-Carapeto A, Sánchez-Quintana D. Left Atrial Appendage Perforation Does Not Always Mean Pericardial Effusion. JACC Cardiovasc Interv. 2018 Jun 11;11(11):1110-1112.
Late Thrombosis Associated With Left Atrial Appendage Closure Devices. Is It Rare or Is It Underdiagnosed?
Referencia: Limpo B, López-Mínguez JR, Millán-Núñez MV, Fuentes-Cañamero ME, González- Fernández R, Nogales-Asensio JM. Late Thrombosis Associated With Left Atrial Appendage Closure Devices. Is It Rare or Is It Underdiagnosed? Rev Esp Cardiol (Engl Ed). 2018 Sep;71(9):767-769.
Safety of MitraClip Implantation in Patients With a Left Ventricular Endocardial Lead for Cardiac Resynchronization Therapy Through the Interventricular Septum.
Referencia: López-Mínguez JR, Estévez-Loureiro R, Millán-Núñez V, Fuentes-Cañamero ME, González-Fernández R, Garrote-Coloma C. Safety of MitraClip Implantation in Patients With a Left Ventricular Endocardial Lead for Cardiac Resynchronization Therapy Through the Interventricular Septum. Rev Esp Cardiol (Engl Ed). 2018 Oct;71(10):867-869.
Usefulness of The Piko-6 Portable Device for Early COPD Detection in Primary Care.
Referencia: Hidalgo Sierra V, Hernández Mezquita MÁ, Palomo Cobos L, García Sánchez M, Castellanos RD, Jodra Sánchez S, Cordovilla Pérez R, Barrueco Ferrero M. Usefulness of The Piko-6 Portable Device for Early COPD Detection in Primary Care. Arch Bronconeumol (Engl Ed). 2018 Sep;54(9):460-466.
Factors associated with poor anticoagulation control with vitaminK antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study.
Referencia: Contreras Muruaga MM, Reig G, Vivancos J, González A, Cardona P, Ramírez- Moreno JM, Martí Fábregas J, Suárez Fernández C; en nombre de los investigadores del estudio ALADIN; Listado de investigadores del estudio ALADIN. Factors associated with poor anticoagulation control with vitaminK antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study. Rev Clin Esp (Barc). 2018 Oct;218(7):327-335.
Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.
Referencia: Kasner SE, Swaminathan B, Lavados P, Sharma M, Muir K, Veltkamp R, Ameriso SF, Endres M, Lutsep H, Messé SR, Spence JD, Nedeltechev K, Perera K, Santo G, Olavarria V, Lindgren A, Bangdiwala S, Shoamanesh A, Berkowitz SD, Mundl H, Connolly SJ, Hart RG; NAVIGATE ESUS Investigators. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial. Lancet Neurol. 2018 Dec;17(12):1053 1060.
Serum uric acid levels and outcome during admission in acute ischaemic stroke, depending on renal function.
Referencia: Arévalo-Lorido JC, Carretero-Gómez J, Robles NR. Serum uric acid levels and outcome during admission in acute ischaemic stroke, depending on renal function. Int J Neurosci. 2018 Oct;128(10):906-912.
Anemia as very late-onset cytomegalovirus disease after kidney transplantation.
Referencia: Hernández-Gallego R, Cerezo I, Robles NR, Barroso S, Romanciuc A, Cubero JJ. Anemia as very late onset cytomegalovirus disease after kidney transplantation. Transpl Infect Dis. 2018 Feb;20(1).
Lack of Correlation of Carotid Intima-Media Index and Peripheral Artery Disease.
Referencia: Laguna P, Robles NR, Lopez Gomez J, Barroso S, Collado G. Lack of Correlation of Carotid Intima Media Index and Peripheral Artery Disease. High Blood Press Cardiovasc Prev. 2018 Dec;25(4):379 383.
PAIT-survey-Prevalence of albuminuria in patients with diabetes and hypertension in Turkey.
Referencia: Fici F, Bakir EA, Beyaz S, Makel W, Robles NR. PAIT-survey-Prevalence of albuminuria in patients with diabetes and hypertension in Turkey. Prim Care Diabetes. 2018 Dec;12(6):558-564.
Analysis of mobile emergency response unit times in attending traffic accidents in Extremadura, Spain.
Referencia: Morales-Gabardino JA, Redondo-Lobato L, Buitrago-Ramírez F. Analysis of mobile emergency response unit times in attending traffic accidents in Extremadura, Spain. Emergencias. 2018 Ago;30(4):265-267.
The mnemonic POUNDing rule in the diagnosis of patients with migraine.
Referencia: Tejero Mas M, Burgos Blanco R, Aguirre Sánchez JJ, Buitrago Ramírez F. The mnemonic POUNDing rule in the diagnosis of patients with migraine. Rev Clin Esp (Barc). 2018 Oct;218(7):388-389.
Numerical analysis of the pressure drop across highly-eccentric coronary stenoses: Application to the calculation of the fractional flow reserve.
Referencia: Agujetas R, González-Fernández MR, Nogales-Asensio JM, Montanero JM. Numerical analysis of the pressure drop across highly-eccentric coronary stenoses: application to the calculation of the fractional flow reserve. Biomed Eng Online. 2018 May 30;17(1):67.
Prevención de los trastornos de la salud mental en atención primaria. Actualización PAPPS 2018.
Referencia: Buitrago Ramírez F, Ciurana Misol R, Chocrón Bentata L, Carmen Fernández Alonso MD, García Campayo J, Montón Franco C, Tizón García JL; Grupo de Salud Mental del PAPPS. Prevención de los trastornos de la salud mental en atención primaria. Actualización PAPPS 2018. Aten Primaria. 2018 May;50 Suppl 1(Suppl 1):83-108.
Vascular Risk Factors and Lesions of Vascular Nature in Magnetic Resonance as Predictors of Progression to Dementia in Patients with Mild Cognitive Impairment.
[Evaluation of quality of life, social stigma and treatment adherence in patients with epilepsy in the Caceres Healthcare Area: a cross-sectional study].
Balancing microbial and mammalian cell functions on calcium ion-modified implant surfaces.
Referencia: Anitua E, Tejero R, Pacha-Olivenza MÁ, Fernández-Calderón MC, Delgado- Rastrollo M, Zalduendo MM, Troya M, Pérez-Giraldo C, González-Martín ML. Balancing microbial and mammalian cell functions on calcium ion-modified implant surfaces. J Biomed Mater Res B Appl Biomater. 2018 Jan;106(1):421-432.
Corrosion behavior of surface modifications on titanium dental implant. In situ bacteria monitoring by electrochemical techniques.
Referencia: Díaz I, Pacha-Olivenza MÁ, Tejero R, Anitua E, González-Martín ML, Escudero ML, García-Alonso MC. Corrosion behavior of surface modifications on titanium dental implant. In situ bacteria monitoring by electrochemical techniques. J Biomed Mater Res B Appl Biomater. 2018 Apr;106(3):997-1009.
The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value.
Referencia: Roman ÁC, Carvajal-Gonzalez JM, Merino JM, Mulero-Navarro S, Fernández- Salguero PM. The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value. Pharmacol Ther. 2018 May;185:50-63.
A Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism.
Referencia: Miret-Casals L, Sebastián D, Brea J, Rico-Leo EM, Palacín M, Fernández- Salguero PM, Loza MI, Albericio F, Zorzano A. Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism. Cell Chem Biol. 2018 Mar 15;25(3):268-278.e4.
Innate/inflammatory bioregulation and clinical effectiveness of whole-body hyperthermia (balneotherapy) in elderly patients with osteoarthritis.
Referencia: Gálvez I, Torres-Piles S, Ortega E. Innate/inflammatory bioregulation and clinical effectiveness of whole-body hyperthermia (balneotherapy) in elderly patients with osteoarthritis. Int J Hyperthermia. 2018;35(1):340-347.
Balneotherapy, immune system, and stress response: A hormetic strategy?
Referencia: Gálvez I, Torres-Piles S, Ortega-Rincón E. Balneotherapy, Immune System, and Stress Response: A Hormetic Strategy? Int J Mol Sci. 2018 Jun 6;19(6):1687.
Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis.
Referencia: Bioque M, García-Portilla MAP, García-Rizo C, Cabrera B, Lobo A, González- Pinto A, Díaz-Caneja CM, Corripio I, Vieta E, Castro-Fornieles J, Bobes J, Gutiérrez-Fraile M, Rodriguez-Jimenez R, Mezquida G, Llerena A, Saiz-Ruiz J, Bernardo M; PEPs GROUP. Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis. Schizophr Res. 2018 Mar;193:188-196.
An update on HLA alleles associated with adverse drug reactions.
Referencia: Fricke-Galindo I, LLerena A, López-López M. An update on HLA alleles associated with adverse drug reactions. Drug Metab Pers Ther. 2017 May 24;32(2):73-87.
Intuitive pharmacogenetic dosing of risperidone according to CYP2D6 phenotype extrapolated from genotype in a cohort of first episode psychosis patients.
Referencia: Mas S, Gassó P, Torra M, Bioque M, Lobo A, González-Pinto A, Olmeda MS, Corripio I, Vieta E, Castro Fornieles J, Rodriguez-Jimenez R, Bobes J, Usall J, Llerena A, Saiz-Ruiz J, Bernardo M, Lafuente A, PEPs Group. Intuitive pharmacogenetic dosing of risperidone according to CYP2D6 phenotype extrapolated from genotype in a cohort of first episode psychosis patients. Eur Neuropsychopharmacol. 2017 Jul;27(7):647-656.
Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment.
Referencia: Jukić MM, Opel N, Ström J, Carrillo-Roa T, Miksys S, Novalen M, Renblom A, Sim SC, Peñas-Lledó EM, Courtet P, Llerena A, Baune BT, de Quervain DJ, Papassotiropoulos A, Tyndale RF, Binder EB, Dannlowski U, Ingelman-Sundberg M. Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment. Mol Psychiatry. 2017 Aug;22(8):1155-1163.
VEGF-related polymorphisms identified by GWAS increase risk for major depression
Referencia: Xie T, Stathopoulou MG, de Andrés F, Siest G, Murray H, Martin M, Cobaleda J, Delgado A, Lamont J, Peñas-LIedó E, LLerena A, Visvikis-Siest S. VEGF-related polymorphisms identified by GWAS and risk for major depression. Transl Psychiatry. 2017 Mar 7;7(3):e1055.
Smoking and Second hand Tobacco Smoke Effects on CYP1A2 and CYP2A6 Phenotypes as Measured by Caffeine Urine Test Omics
Referencia: Yılmaz ŞG, Llerena A, De Andrés F, Karakaş Ü, Gündoğar H, Erciyas K, Kimyon S, Mete A, Güngör K, Özdemir V. Water pipe (Shisha, Hookah, Arghile) Smoking and Secondhand Tobacco Smoke Effects on CYP1A2 and CYP2A6 Phenotypes as Measured by Caffeine Urine Test. OMICS. 2017 Mar;21(3):177-182.
Lessons from Cuba for Global Precision Medicine: CYP2D6 Genotype Is Not a Robust Predictor of CYP2D6 Ultrarapid Metabolism Omics
Referencia: Dorado P, González I, Naranjo ME, de Andrés F, Peñas-Lledó EM, Calzadilla LR, LLerena A. Lessons from Cuba for Global Precision Medicine: CYP2D6 Genotype Is Not a Robust Predictor of CYP2D6 Ultrarapid Metabolism. OMICS. 2017 Jan;21(1):17-26.
Anti inflammatory effect as a mechanism of effectiveness underlying the clinical benefits of pelotherapy in osteoarthritis patients: regulation of the altered inflammatory and stress feedback response.
Referencia: Ortega E, Gálvez I, Hinchado MD, Guerrero J, Martín-Cordero L, Torres-Piles S. Anti inflammatory effect as a mechanism of effectiveness underlying the clinical benefits of pelotherapy in osteoarthritis patients: regulation of the altered inflammatory and stress feedback response. Int J Biometeorol. 2017 Oct;61(10):1777-1785.
Immune-Neuroendocrine Dysregulation in Patients with Osteoarthritis: A Revision and a Pilot Study.
Referencia: Galvez I, Torres-Piles S, Hinchado MD, Alvarez-Barrientos A, Torralbo-Jimenez P, Guerrero J, Martin-Cordero L, Ortega E. Immune-Neuroendocrine Dysregulation in Patients with Osteoarthritis: A Revision and a Pilot Study. Endocr Metab Immune Disord Drug Targets. 2017;17(1):78-85.
Relevance of the ancestry for the variability of the drug metabolizing enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population.
Referencia: Céspedes-Garro C, Rodrigues-Soares F, Jiménez-Arce G, Naranjo MG, Tarazona- Santos E, Fariñas H, Barrantes R, Llerena A; CEIBA.FP Consortium of the Ibero- American Network of Pharmacogenetics & Pharmacogenomics RIBEF. Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican population. Rev Biol Trop. 2016 Sep;64(3):1067-76.
Can the CEIBA Cocktail Designed for Human Cytochrome P450 Enzymes be Used in the Rat for Drug Interaction Studies?
Referencia: Magalhães P, De Andrés F, Falcão A, LLerena A, Alves G. Can the CEIBA Cocktail Designed for Human Cytochrome P450 Enzymes be Used in the Rat for Drug Interaction Studies? J Pharm Pharm Sci. 2016 Oct-Dec;19(4):520-529.
Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment.
Referencia: Jukić MM, Opel N, Ström J, Carrillo-Roa T, Miksys S, Novalen M, Renblom A, Sim SC, Peñas-Lledó EM, Courtet P, Llerena A, Baune BT, de Quervain DJ, Papassotiropoulos A, Tyndale RF, Binder EB, Dannlowski U, Ingelman-Sundberg M. Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment. Mol Psychiatry. 2017 Aug;22(8):1155-1163.
To Genotype or Phenotype for Personalized Medicine? CYP450 Drug Metabolizing Enzyme Genotype-Phenotype Concordance and Discordance in the Ecuadorian Population.
Referencia: De Andrés F, Terán S, Hernández F, Terán E, LLerena A. To Genotype or Phenotype for Personalized Medicine? CYP450 Drug Metabolizing Enzyme Genotype-Phenotype Concordance and Discordance in the Ecuadorian Population. OMICS. 2016 Dec;20(12):699-710.
Genetic variability of CYP2C9*2 and CYP2C9*3 in seven indigenous groups from Mexico
Referencia: Sánchez-Pozos K, Rivera-Santiago C, García-Rodríguez MH, Ortiz-López MG, Peña-Espinoza BI, Granados-Silvestre MLÁ, Llerena A, Menjívar M. Genetic variability of CYP2C9*2 and CYP2C9*3 in seven indigenous groups from Mexico. Pharmacogenomics. 2016 Nov;17(17):1881-1889.
Pharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America.
Referencia: Sosa-Macías M, Teran E, Waters W, Fors MM, Altamirano C, Jung-Cook H,Galaviz-Hernández C, López- López M, Remírez D, Moya GE, Hernández F, Fariñas H, Ramírez R, Céspedes-Garro C, Tarazona-Santos E, LLerena A. Pharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America. Pharmacogenomics. 2016 Nov;17(16):1741-1747.
Allele and genotype frequencies of genes relevant to anti-epileptic drug therapy in Mexican-Mestizo healthy volunteers.
Referencia: Fricke-Galindo I, Ortega-Vázquez A, Monroy-Jaramillo N, Dorado P, Jung-Cook H, Peñas-Lledó E, LLerena A, López-López M. Allele and genotype frequencies of genes relevant to anti-epileptic drug therapy in Mexican-Mestizo healthy volunteers. Pharmacogenomics. 2016 Nov;17(17):1913-1930.
Simultaneous Determination of Cytochrome P450 Oxidation Capacity in Humans: A Review on the Phenotyping Cocktail Approach Current
Referencia: de Andrés F, LLerena A. Simultaneous Determination of Cytochrome P450 Oxidation Capacity in Humans: A Review on the Phenotyping Cocktail Approach. Curr Pharm Biotechnol. 2016;17(13):1159-1180.
Pharmacogenetic study of antipsychotic induced acute extrapyramidal symptoms in a first episode psychosis cohort: role of dopamine, serotonin and glutamate candidate genes.
Referencia: Mas S, Gassó P, Lafuente A, Bioque M, Lobo A, Gonzàlez-Pinto A, Olmeda MS, Corripio I, Llerena A, Cabrera B, Saiz-Ruiz J, Bernardo M; PEPs GROUP. Pharmacogenetic study of antipsychotic induced acute extrapyramidal symptoms in a first episode psychosis cohort: role of dopamine, serotonin and glutamate candidate genes. Pharmacogenomics J. 2016 Oct;16(5):439-45.
High frequency of CYP2D6 ultrarapid metabolizers in Spain: controversy about their misclassification in worldwide population studies.
Referencia: Naranjo ME, de Andrés F, Delgado A, Cobaleda J, Peñas-Lledó EM, LLerena A. High frequency of CYP2D6 ultrarapid metabolizers in Spain: controversy about their misclassification in worldwide population studies. Pharmacogenomics J. 2016 Oct;16(5):485-90.
An Open Letter in Support of Transformative Biotechnology and Social Innovation: SANKO University Innovation Summit in Medicine and Integrative Biology
Referencia: Saygılı Eİ, Abou-Zeid AH, Akkın SM, Aklillu E, Barlas İÖ, Borda-Rodriguez A, Boschele FA, Çetin Z, Coşkun E, Coşkun Y, Dağlı G, Dai TU, Dandara C, Dereli T, Elbeyli L, Endrenyi L, Eyigün CP, Georgakilas A, Günbulut B, Güngör K, Güzelbey A, Hekim C, Huzair F, Kimyon S, Karakaş Ü, Lin B, LLerena A, Masimirembwa C, McNally R, Mete A, Sancar P, Srivastava S, Steuten LM, Tanrıöver O, Tyfield D, Töre Vİ, Vuruşkan D, Wang W, Warnich L, Wonkam A, Yıldırım YZ, Yılmaz İ, Sınav A, Hekim N. An Open Letter in Support of Transformative Biotechnology and Social Innovation: SANKO University Innovation Summit in Medicine and Integrative Biology, Gaziantep, Turkey, May 5-7, 2016. OMICS. 2016 Apr;20(4):259-62.
High frequency of CYP2D6 ultrarapid metabolizer genotypes in an Ashkenazi Jewish population from Argentina.
Referencia: Moya G, Dorado P, Ferreiro V, Naranjo MEG, Peñas-Lledó EM, LLerena A. High frequency of CYP2D6 ultrarapid metabolizer genotypes in an Ashkenazi Jewish population from Argentina. Pharmacogenomics J. 2017 Jul;17(4):378-381.
Predictive biomarkers candidates for patients with metastatic colorectal cancer treated with bevacizumab-containing regimen.
Referencia: González-Vacarezza N, Alonso I, Arroyo G, Martínez J, De Andrés F, LLerena A, Estévez-Carrizo F. Predictive biomarkers candidates for patients with metastatic colorectal cancer treated with bevacizumab-containing regimen. Drug Metab Pers Ther. 2016 Jun 1;31(2):83-90.
Progress in pharmacogenetics: consortiums and new strategies
Referencia: Maroñas O, Latorre A, Dopazo J, Pirmohamed M, Rodríguez-Antona C, Siest G, Carracedo Á, LLerena A. Progress in pharmacogenetics: consortiums and new strategies. Drug Metab Pers Ther. 2016 Mar;31(1):17-23.
Interethnic variability of pharmacogenetic biomarkers in Mexican healthy volunteers: a report from the RIBEF (Ibero-American Network of Pharmacogenetics and Pharmacogenomics).
Referencia: Fricke-Galindo I, Jung-Cook H, LLerena A, López-López M. Interethnic variability of pharmacogenetic biomarkers in Mexican healthy volunteers: a report from the RIBEF (Ibero-American Network of Pharmacogenetics and Pharmacogenomics). Drug Metab Pers Ther. 2016 Jun 1;31(2):61-81.
CYP450 genotype and pharmacogenetic association studies: a critical appraisal.
Referencia: Shah RR, Gaedigk A, LLerena A, Eichelbaum M, Stingl J, Smith RL. CYP450 genotype and pharmacogenetic association studies: a critical appraisal. Pharmacogenomics. 2016 Feb;17(3):259-75.
Multiplex Phenotyping for Systems Medicine: A One- Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach.
Referencia: de Andrés F, Terán S, Bovera M, Fariñas H, Terán E, LLerena A. Multiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach. OMICS. 2016 Feb;20(2):88-96.
A Pharmacovigilance Study In First Episode Of Psychosis; Psychopharmacological Interventions And Safety Profiles In The Peps Project.
Referencia: Bioque M, Llerena A, Cabrera B, Mezquida G, Lobo A, González-Pinto A, Díaz- Caneja CM, Corripio I, Aguilar EJ, Bulbena A, Castro-Fornieles J, Vieta E, Lafuente A, Mas S, Parellada M, Saiz-Ruiz J, Cuesta MJ, Bernardo M; PEPs GROUP. A Pharmacovigilance Study in First Episode of Psychosis: Psychopharmacological Interventions and Safety Profiles in the PEPs Project. Int J Neuropsychopharmacol. 2016 Mar 31;19(4):pyv121.
Interethnic variation of CYP2C19 alleles, ´predicted´ phenotypes and ´measured´ metabolic phenotypes across world populations.
Referencia: Fricke-Galindo I, Céspedes-Garro C, Rodrigues-Soares F, Naranjo ME, Delgado Á, de Andrés F, López López M, Peñas-Lledó E, LLerena A. Interethnic variation of CYP2C19 alleles, ´predicted´ phenotypes and ´measured´ metabolic phenotypes across world populations. Pharmacogenomics J. 2016 Apr;16(2):113-23.
CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy.
Referencia: Ortega-Vázquez A, Dorado P, Fricke-Galindo I, Jung-Cook H, Monroy-Jaramillo N, Martínez-Juárez IE, Familiar-López I, Peñas-Lledó E, LLerena A, López-López M. CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy. Pharmacogenomics J. 2016 Jun;16(3):286-92.
Immunomodulatory effects of Santolina chamaecyparissus leaf extracts on human neutrophil functions.
Referencia: Boudoukha C, Bouriche H, Ortega E, Senator A. Immunomodulatory effects of Santolina chamaecyparissus leaf extracts on human neutrophil functions. Pharm Biol. 2016;54(4):667-73.
Hsp70 basal levels, a tissue marker of the rate of aging and longevity in mice.
Referencia: de Toda IM, Vida C, Ortega E, De La Fuente M. Hsp70 basal levels, a tissue marker of the rate of aging and longevity in mice. Exp Gerontol. 2016 Nov;84:21-28.
Risk for self-reported anorexia or bulimia nervosa based on drive for thinness and negative affect clusters/dimensions during adolescence: A three-year prospective study of the TChAD cohort.
Referencia: Peñas-Lledó E, Bulik CM, Lichtenstein P, Larsson H, Baker JH. Risk for self- reported anorexia or bulimia nervosa based on drive for thinness and negative affect clusters/dimensions during adolescence: A three-year prospective study of the TChAD cohort. Int J Eat Disord. 2015 Sep;48(6):692-9.
Worldwide interethnic variability and geographical distribution of CYP2C9 genotypes and phenotypes.
Referencia: Céspedes-Garro C, Fricke-Galindo I, Naranjo ME, Rodrigues-Soares F, Fariñas H, de Andrés F, López López M, Peñas-Lledó EM, LLerena A. Worldwide interethnic variability and geographical distribution of CYP2C9 genotypes and phenotypes. Expert Opin Drug Metab Toxicol. 2015;11(12):1893-905.
The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans.
Referencia: Bedada W, de Andrés F, Engidawork E, Pohanka A, Beck O, Bertilsson L, Llerena A, Aklillu E. The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans. J Clin Psychopharmacol. 2015 Dec;35(6):694-9.
Metabolic phenotype prediction from genotyping data: a bottleneck for the implementation of pharmacogenetics in drug development and clinical practice
Referencia: LLerena A, Peñas-Lledó EM. Metabolic phenotype prediction from genotyping data: a bottleneck for the implementation of pharmacogenetics in drug development and clinical practice. Drug Metab Pers Ther. 2015 Sep;30(3):143-5.
An Appeal to the Global Health Community for a Tripartite Innovation: an Essential Diagnostics List, Health in All Policies, and See-Through 21st Century Science and Ethics.
Referencia: Dove ES, Barlas IÖ, Birch K, Boehme C, Borda-Rodriguez A, Byne WM, Chaverneff F, Coşkun Y, Dahl ML, Dereli T, Diwakar S, Elbeyli L, Endrenyi L, Eroğlu-Kesim B, Ferguson LR, Güngör K, Gürsoy U, Hekim N, Huzair F, Kaushik K, Kickbusch I, Kıroğlu O, Kolker E, Könönen E, Lin B, Llerena A, Malhan F, Nair B, Patrinos GP, Şardaş S, Sert Ö, Srivastava S, Steuten LM, Toraman C, Vayena E, Wang W, Warnich L, Özdemir V. An Appeal to the Global Health Community for a Tripartite Innovation: An "Essential Diagnostics List," "Health in All Policies," and "See-Through 21(st) Century Science and Ethics". OMICS. 2015 Aug;19(8):435-42.
Success stories in genomic medicine from resource-limited countries
Referencia: Mitropoulos K, Al Jaibeji H, Forero DA, Laissue P, Wonkam A, Lopez-Correa C, Mohamed Z, Chantratita W, Lee MT, Llerena A, Brand A, Ali BR, Patrinos GP. Success stories in genomic medicine from resource limited countries. Hum Genomics. 2015 Jun 18;9(1):11.
Pharmacogenetics of adverse reactions to antiepileptic drugs.
Referencia: Fricke-Galindo I, Jung-Cook H, LLerena A, López-López M. Pharmacogenetics of adverse reactions to antiepileptic drugs. Neurologia (Engl Ed). 2018 Apr;33(3):165-176.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Referencia: Hicks JK, Bishop JR, Sangkuhl K, Müller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A; Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34.
A code of Ethics for Ethicists: What Would Pierre Bourdieu Say? “Do Not Misuse Social Capital in the Age of Consortia Ethics”.
Referencia: Özdemir V, Kılıç H, Yıldırım A, Vayena E, Dove ES, Güngör K, LLerena A, Şardaş S. A code of ethics for ethicists: what would Pierre Bourdieu say? "Do not misuse social capital in the age of consortia ethics". Am J Bioeth. 2015;15(5):64-7.
Interethnic relationships of CYP2D6 variants in native and Mestizo populations sharing the same ecosystem.
Referencia: Perez-Paramo YX, Hernandez-Cabrera F, Dorado P, Llerena A, Muñoz-Jimenez S, Ortiz-Lopez R, Rojas Martinez A. Interethnic relationships of CYP2D6 variants in native and Mestizo populations sharing the same ecosystem. Pharmacogenomics. 2015;16(7):703-12.
Population pharmacogenetics of Ibero-Latinoamerican populations (MESTIFAR 2014).
Referencia: Sosa-Macias M, Moya GE, LLerena A, Ramírez R, Terán E, Peñas-LLedó EM, Tarazona-Santos E, Galaviz Hernández C, Céspedes-Garro C, Acosta H. Population pharmacogenetics of Ibero-Latinoamerican populations (MESTIFAR 2014). Pharmacogenomics. 2015;16(7):673-6.
Trends in Antihypertensive Drug Use in Spanish Primary Health Care (1990-2012)
Referencia: Cáceres MC, Moyano P, Fariñas H, Cobaleda J, Pijierro A, Dorado P, Llerena A. Trends in Antihypertensive Drug Use in Spanish Primary Health Care (1990-2012). Advances in Pharmacoepidemiology and Drug Safety. 2015. 04(01)
Pharmacogenomic information in drug labels: European Medicines Agency perspective.
Referencia: Ehmann F, Caneva L, Prasad K, Paulmichl M, Maliepaard M, Llerena A, Ingelman- Sundberg M, Papaluca Amati M. Pharmacogenomic information in drug labels: European Medicines Agency perspective. Pharmacogenomics J. 2015 Jun;15(3):201-10.
ABCB1 gene polymorphisms and violent suicide attempt among survivors.
Referencia: Peñas-Lledó E, Guillaume S, Delgado A, Naranjo ME, Jaussent I, LLerena A, Courtet P. ABCB1 gene polymorphisms and violent suicide attempt among survivors. J Psychiatr Res. 2015 Feb;61:52-6.
Pharmacogenetics in Central American healthy volunteers: interethnic variability.
Referencia: Céspedes-Garro C, Naranjo ME, Ramírez R, Serrano V, Fariñas H, Barrantes R, LLerena A; CEIBA Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics RIBEF. Pharmacogenetics in Central American healthy volunteers: interethnic variability. Drug Metab Pers Ther. 2015 Mar;30(1):19-31.
High frequency and founder effect of the CYP3A4*20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme.
Referencia: Apellániz-Ruiz M, Inglada-Pérez L, Naranjo ME, Sánchez L, Mancikova V, Currás-Freixes M, de Cubas AA, Comino-Méndez I, Triki S, Rebai A, Rasool M, Moya G, Grazina M, Opocher G, Cascón A, Taboada-Echalar P, Ingelman-Sundberg M, Carracedo A, Robledo M, Llerena A, Rodríguez-Antona C. High frequency and founder effect of the CYP3A4*20 loss-of-function allele in the Spanish population classifies CYP3A4 as a polymorphic enzyme. Pharmacogenomics J. 2015 Jun;15(3):288-92.
A Combined high CYP2D6-CYP2C19 metabolic capacity and severity of the objective circumstances related to the suicide attempt.
Referencia: Peñas-Lledó E, Guillaume S, Naranjo ME, Delgado A, Jaussent I, Blasco- Fontecilla H, Courtet P, Llerena A. A combined high CYP2D6-CYP2C19 metabolic capacity is associated with the severity of suicide attempt as measured by objective circumstances. Pharmacogenomics J. 2015 Apr;15(2):172-6.
Regulación por el ejercicio físico del estado inflamatorio alterado: Respuesta en pacientes con fibromialgia.
Referencia: Bote M.E, Ortega E. Regulación por el ejercicio físico del estado inflamatorio alterado: Respuesta en pacientes con fibromialgia. Archivos de Medicina del Deporte. 2015 32. 136-143.
[Validation of the telephone call as a method for measuring compliance to arterial hypertension treatment in Extremadura].
Referencia: Espinosa-García J, Cobaleda-Polo J, González-Velasco M, Fernández-Bergés D. Validación de la llamada telefónica como método de medida del cumplimiento terapéutico de la hipertensión arterial en Extremadura [Validation of the telephone call as a method for measuring compliance to arterial hypertension treatment in Extremadura]. Semergen. 2014 Oct;40(7):366-73.
First MEPS/HPLC assay for the simultaneous determination of venlafaxine and O-desmethyl venlafaxine in human plasma.
Referencia: Magalhães P, Alves G, Rodrigues M, LLerena A, Falcão A. First MEPS/HPLC assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human plasma. Bioanalysis. 2014;6(22):3025-38.
CYP2D6 genetic polymorphisms in Southern Mexican Mayan Lacandones and Mestizos from Chiapas.
Referencia: López-López M, Peñas-Lledó E, Dorado P, Ortega A, Corona T, Ochoa A, Yescas P, Alonso E, LLerena A. CYP2D6 genetic polymorphisms in Southern Mexican Mayan Lacandones and Mestizos from Chiapas. Pharmacogenomics. 2014;15(15):1859-65.
Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations.
Referencia: LLerena A, Naranjo ME, Rodrigues-Soares F, Penas-LLedó EM, Fariñas H, Tarazona-Santos E. Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations. Expert Opin Drug Metab Toxicol. 2014 Nov;10(11):1569-83.
Translating biotechnology to Knowledge-based Innovation, Peace and Development? Deploy Science Peace Corps! An open letter to world leaders.
Referencia: Hekim N, Coşkun Y, Sınav A, Abou-Zeid AH, Ağırbaşlı M, Akintola SO, Aynacıoğlu Ş, Bayram M, Bragazzi NL, Dandara C, Dereli T, Dove ES, Elbeyli L, Endrenyi L, Erciyas K, Faris J, Ferguson LR, Göğüş F, Güngör K, Gürsoy M, Gürsoy UK, Karaömerlioğlu MA, Kickbusch I, Kılıç T, Kılınç M, Kocagöz T, Lin B, Llerena A, Manolopoulos VG, Nair B, Özkan B, Pang T, Sardaş Ş, Srivastava S, Toraman C, Üstün K, Warnich L, Wonkam A, Yakıcıer MC, Yaşar Ü, Özdemir V. Translating biotechnology to knowledge-based innovation, peace, and development? Deploy a Science Peace Corps--an open letter to world leaders. OMICS. 2014 Jul;18(7):415-20.
Relationship between the CYP2C9 IVS8-109A>T polymorphism and high losartan hydroxylation in healthy Ecuadorian volunteers.
Referencia: Dorado P, Gallego A, Peñas-LLedó E, Terán E, LLerena A. Relationship between the CYP2C9 IVS8-109A>T polymorphism and high losartan hydroxylation in healthy Ecuadorian volunteers. Pharmacogenomics. 2014 Aug;15(11):1417-21.
Bernard Lerer: Recipient of the 2014 Inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics).
Referencia: Ozdemir V, Endrenyi L, Aynacıoğlu S, Bragazzi NL, Dandara C, Dove ES, Ferguson LR, Geraci CJ, Hafen E, Kesim BE, Kolker E, Lee EJ, Llerena A, Nacak M, Shimoda K, Someya T, Srivastava S, Tomlinson B, Vayena E, Warnich L, Yaşar U. Bernard Lerer: recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics). OMICS. 2014 Apr;18(4):211-21.
A rapid and simple LC-MS/MS method for the simultaneous evaluation of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 hydroxylation capacity.
Referencia: de Andrés F, Sosa-Macías M, Llerena A. A rapid and simple LC-MS/MS method for the simultaneous evaluation of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 hydroxylation capacity. Bioanalysis. 2014 Mar;6(5):683-96.
Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers.
Referencia: Magalhães P, Alves G, Llerena A, Falcão A. Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers. Drug Metabol Drug Interact. 2014;29(3):129-41.
Liver enzyme abnormalities during antipsychotic treatment: a case report of risperidone-associated hepatotoxicity.
Referencia: López-Torres E, Süveges A, Peñas-LLedó EM, Doña A, Dorado P, LLerena A, Berecz R. Liver enzyme abnormalities during antipsychotic treatment: a case report of risperidone-associated hepatotoxicity. Drug Metabol Drug Interact. 2014;29(2):123-6.
CYP2D6 gene polymorphisms and predicted phenotype in eight Indigenous groups from northwestern of Mexico.
Referencia: Lazalde-Ramos BP, Martínez-Fierro Mde L, Galaviz-Hernández C, Garza-Veloz I, Naranjo ME, Sosa Macías M, Llerena A. CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico. Pharmacogenomics. 2014 Feb;15(3):339-48.
Novel CYP2C9 genetic polymorphisms and assessment of their impact on hydroxylation capacity.
Referencia: Dorado P, Peñas-Lledo EM, Llerena A. Research Highlights: novel CYP2C9 genetic polymorphisms and assessment of their impact on hydroxylation capacity. Pharmacogenomics. 2014 Feb;15(3):261-4.
Towards more transparent and reproducible OMICS studies through a common metadata checklist and data publications.
Referencia: Kolker E, Özdemir V, Martens L, Hancock W, Anderson G, Anderson N, Aynacioglu S, Baranova A, Campagna SR, Chen R, Choiniere J, Dearth SP, Feng WC, Ferguson L, Fox G, Frishman D, Grossman R, Heath A, Higdon R, Hutz MH, Janko I, Jiang L, Joshi S, Kel A, Kemnitz JW, Kohane IS, Kolker N, Lancet D, Lee E, Li W, Lisitsa A, Llerena A, Macnealy-Koch C, Marshall JC, Masuzzo P, May A, Mias G, Monroe M, Montague E, Mooney S, Nesvizhskii A, Noronha S, Omenn G, Rajasimha H, Ramamoorthy P, Sheehan J, Smarr L, Smith CV, Smith T, Snyder M, Rapole S, Srivastava S, Stanberry L, Stewart E, Toppo S, Uetz P, Verheggen K, Voy BH, Warnich L, Wilhelm SW, Yandl G. Toward more transparent and reproducible omics studies through a common metadata checklist and data publications. OMICS. 2014 Jan;18(1):10 4.
Ready to put metadata on the post-2015 development agenda? Linking data publications to responsible innovation and science diplomacy.
Referencia: Özdemir V, Kolker E, Hotez PJ, Mohin S, Prainsack B, Wynne B, Vayena E, Coşkun Y, Dereli T, Huzair F, Borda-Rodriguez A, Bragazzi NL, Faris J, Ramesar R, Wonkam A, Dandara C, Nair B, Llerena A, Kılıç K, Jain R, Reddy PJ, Gollapalli K, Srivastava S, Kickbusch I. Ready to put metadata on the post-2015 development agenda? Linking data publications to responsible innovation and science diplomacy. OMICS. 2014 Jan;18(1):1-9.
Pharmacogenetic potential biomarkers for carbamazepine adverse drug reactions and clinical response
Referencia: Jaramillo NM, Galindo IF, Vázquez AO, Cook HJ, LLerena A, López ML. Pharmacogenetic potential biomarkers for carbamazepine adverse drug reactions and clinical response. Drug Metabol Drug Interact. 2014;29(2):67-79.
Present status and perspective of Pharmacogenetics in Mexico.
Referencia: Cuautle-Rodríguez P, Llerena A, Molina-Guarneros J. Present status and perspective of pharmacogenetics in Mexico. Drug Metabol Drug Interact. 2014;29(1):37-45.
Interethnic differences in the relevance of CYP2C9 genotype and environmental factors on diclofenac metabolism in Hispanics from Cuba and Spain.
Referencia: Llerena A, Alvarez M, Dorado P, González I, Peñas-LLedó E, Pérez B, Cobaleda J, Calzadilla LR. Interethnic differences in the relevance of CYP2C9 genotype and environmental factors for diclofenac metabolism in Hispanics from Cuba and Spain. Pharmacogenomics J. 2014 Jun;14(3):229-34.
CYP2D6 polymorphism, mental and personality disorders in suicide attempters.
Referencia: Blasco-Fontecilla H, Peñas-Lledó E, Vaquero-Lorenzo C, Dorado P, Saiz-Ruiz J, Llerena A, Baca-García E. CYP2D6 polymorphism and mental and personality disorders in suicide attempters. J Pers Disord. 2014 Dec;28(6):873-83.
Altered profile of chemokines in fibromyalgia patients.
Referencia: García JJ, Cidoncha A, Bote ME, Hinchado MD, Ortega E. Altered profile of chemokines in fibromyalgia patients. Ann Clin Biochem. 2014 Sep;51(Pt 5):576-81.
An exploratory study of the effect of regular aquatic exercise on the function of neutrophils from women with fibromyalgia: role of IL-8 and noradrenaline.
Referencia: Bote ME, García JJ, Hinchado MD, Ortega E. An exploratory study of the effect of regular aquatic exercise on the function of neutrophils from women with fibromyalgia: role of IL-8 and noradrenaline. Brain Behav Immun. 2014 Jul;39:107-12.
Referencia: Marcos A, Manonelles P, Palacios N, Wärnberg J, Casajús JA, Pérez M, Aznar S, Benito PJ, Martínez-Gomez D, Ortega FB, Ortega E, Urrialde R. Physical activity, hydration and health. Nutr Hosp. 2014 Jun 1;29(6):1224-39.
Cognitive behaviour therapy response and dropout rate across purging and nonpurging bulimia nervosa and binge eating disorder: DSM-5 implications.
Referencia: Agüera Z, Riesco N, Jiménez-Murcia S, Islam MA, Granero R, Vicente E, Peñas- Lledó E, Arcelus J, Sánchez I, Menchon JM, Fernández-Aranda F. Cognitive behaviour therapy response and dropout rate across purging and nonpurging bulimia nervosa and binge eating disorder: DSM-5 implications. BMC Psychiatry. 2013 Nov 7;13:285.
Differences in cognitive behavioral therapy dropout rates between bulimia nervosa subtypes based on drive for thinness and depression.
Referencia: Peñas-Lledó E, Agüera Z, Sánchez I, Gunnard K, Jiménez-Murcia S, Fernández- Aranda F. Differences in cognitive behavioral therapy dropout rates between bulimia nervosa subtypes based on drive for thinness and depression. Psychother Psychosom. 2013;82(2):125-6.
Building a Socio-Technical GPS for Global Personalized Medicine.
Referencia: Özdemir V, Llerena A, Mckinnon R, Srivastava S, Dove ES, Ferguson LR, Masellis M, Warnich L. Building a Socio-Technical GPS for Global Personalized Medicine. Pharmacogenomics and Personalized Medicine. 2013
Characterization of CYP2D6 genotypes and metabolic profiles in the Portuguese population: pharmacogenetic implications.
Referencia: Albuquerque J, Ribeiro C, Naranjo MEG, Llerena A, Grazina M; CEIBA.FP Consortium of the Ibero American Network of Pharmacogenetics & Pharmacogenomics RIBEF §. Characterization of CYP2D6 genotypes and metabolic profiles in the Portuguese population: pharmacogenetic implications. Per Med. 2013 Sep;10(7):709-718.
Cytochrome P450 genetic polymorphisms of Mexican indigenous populations.
Referencia: Sosa-Macías M, Llerena A. Cytochrome P450 genetic polymorphisms of Mexican indigenous populations. Drug Metabol Drug Interact. 2013;28(4):193-208.
Evaluation of drug metabolizing enzyme hydroxylation phenotypes in Hispanic populations: the CEIBA cocktail.
Referencia: de Andrés F, Sosa-Macías M, Lazalde-Ramos BP, Naranjo ME, Tarazona-Santos E, Llerena A; CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics RIBEFa. Evaluation of drug-metabolizing enzyme hydroxylation phenotypes in Hispanic populations: the CEIBA cocktail. Drug Metabol Drug Interact. 2013;28(3):135-46.
MDR-1 genotypes and quetiapine pharmacokinetics in healthy volunteers.
Referencia: González-Vacarezza N, Dorado P, Peñas-Lledó EM, Fariñas H, Estévez-Carrizo FE, Llerena A. MDR-1 genotypes and quetiapine pharmacokinetics in healthy volunteers. Drug Metabol Drug Interact. 2013;28(3):163-6.
Newly identified synergy between clopidogrel and calcium-channel blockers for blood pressure regulation possibly involves CYP2C19 rs4244285.
Referencia: Stathopoulou MG, Monteiro P, Shahabi P, Peñas-Lledó E, El Shamieh S, Silva Santos L, Thilly N, Siest G, Llerena A, Visvikis-Siest S. Newly identified synergy between clopidogrel and calcium-channel blockers for blood pressure regulation possibly involves CYP2C19 rs4244285. Int J Cardiol. 2013 Oct 3;168(3):3057-8.
Highlights from the latest articles in CYP2D6 activity and breast cancer outcomes during treatment with tamoxifen.
Referencia: Dorado P, Peñas-Lledó E, Llerena A. Highlights from the latest articles in CYP2D6 activity and breast cancer outcomes during treatment with tamoxifen. Pharmacogenomics. 2013 Apr;14(6):604-6.
Influence of admixture components on CYP2C9*2 allele frequency in eight Indigenous populations from Northwest Mexico.
Referencia: Sosa-Macías M, Lazalde-Ramos BP, Galaviz-Hernández C, Rangel-Villalobos H, Salazar-Flores J, Martínez-Sevilla VM, Martínez-Fierro ML, Dorado P, Wong ML, Licinio J, LLerena A. Influence of admixture components on CYP2C9*2 allele frequency in eight indigenous populations from Northwest Mexico. Pharmacogenomics J. 2013 Dec;13(6):567-72.
Pharmacogenetics of clinical response to risperidone.
Referencia: Llerena A, Berecz R, Peñas-Lledó E, Süveges A, Fariñas H. Pharmacogenetics of clinical response to risperidone. Pharmacogenomics. 2013 Jan;14(2):177-94.
Interethnic differences in UGT1A4 genetic polymorphisms between Mexican Mestizo and Spanish populations.
Referencia: López M, Dorado P, Ortega A, Peñas-Lledó E, Monroy N, Silva-Zolezzi I, Cobaleda J, Gallego-Aguilera A, Alonso ME, Llerena A. Interethnic differences in UGT1A4 genetic polymorphisms between Mexican Mestizo and Spanish populations. Mol Biol Rep. 2013 Apr;40(4):3187-92.
Assessing clinical and functional outcomes in a gene-environment interaction study in first episode of psychosis (PEPs).
Referencia: Bernardo M, Bioque M, Parellada M, Saiz Ruiz J, Cuesta MJ, Llerena A, Sanjuán J, Castro-Fornieles J, Arango C, Cabrera B; PEPs Group. Assessing clinical and functional outcomes in a gene-environment interaction study in first episode of psychosis (PEPs). Rev Psiquiatr Salud Ment. 2013 Jan-Mar;6(1):4-16.
Use of Pharmacogenetics in bioequivalence studies to reduce sample size: An example with mirtazapine and CYP2D6.
Referencia: González-Vacarezza N, Abad-Santos F, Carcas-Sansuan A, Dorado P, Peñas-Lledó E, Estévez-Carrizo F, Llerena A. Use of pharmacogenetics in bioequivalence studies to reduce sample size: an example with mirtazapine and CYP2D6. Pharmacogenomics J. 2013 Oct;13(5):452-5.
CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitryptiline monotherapy treatment in major depressive patients.
Referencia: Peñas-Lledó EM, Trejo HD, Dorado P, Ortega A, Jung H, Alonso E, Naranjo ME, López-López M, Llerena A. CYP2D6 ultrarapid metabolism and early dropout from fluoxetine or amitriptyline monotherapy treatment in major depressive patients. Mol Psychiatry. 2013 Jan;18(1):8-9.
Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms.
Referencia: Dorado P, López-Torres E, Peñas-Lledó EM, Martínez-Antón J, Llerena A. Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms. Pharmacogenomics J. 2013 Aug;13(4):359-61.
Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population.
Referencia: Almoguera B, Riveiro-Alvarez R, Lopez-Castroman J, Dorado P, Vaquero-Lorenzo C, Fernandez-Piqueras J, Llerena A, Abad-Santos F, Baca-García E, Dal-Ré R, Ayuso C; Spanish Consortium of Pharmacogenetics Research in Schizophrenia. Association of common genetic variants with risperidone adverse events in a Spanish schizophrenic population. Pharmacogenomics J. 2013 Apr;13(2):197-204.
Mecanismos de efectividad del ejercicio físico en el tratamiento del síndrome de la fibromialgia: respuestas anti-inflamatorias y anti-estrés.
Referencia: Ortega E. Mecanismos de efectividad del ejercicio físico en el tratamiento del síndrome de la fibromialgia: respuestas anti-inflamatorias y anti-estrés. Archivos de Medicina del Deporte. 2013, 30. 108-113.
Effects of habitual exercise on the eHsp72-induced release of inflammatory cytokines by macrophages from obese Zucker rats.
Referencia: Garcia JJ, Martin-Cordero L, Hinchado MD, Bote ME, Ortega E. Effects of habitual exercise on the eHsp72-induced release of inflammatory cytokines by macrophages from obese Zucker rats. Int J Sports Med. 2013 Jun;34(6):559-64.
Influence of exercise on NA- and Hsp72-induced release of IFNγ by the peritoneal suspension of macrophages and lymphocytes from genetically obese Zucker rats.
Referencia: Martín-Cordero L, García JJ, Hinchado MD, Bote E, Ortega E. Influence of exercise on NA- and Hsp72-induced release of IFNγ by the peritoneal suspension of macrophages and lymphocytes from genetically obese Zucker rats. J Physiol Biochem. 2013 Mar;69(1):125-31.
Combined activity of post-exercise concentrations of NA and eHsp72 on human neutrophil function: role of cAMP.
Referencia: Giraldo E, Hinchado MD, Ortega E. Combined activity of post-exercise concentrations of NA and eHsp72 on human neutrophil function: role of cAMP. J Cell Physiol. 2013 Sep;228(9):1902-6.
Noradrenaline-mediated inhibition of inflammatory cytokines is altered in macrophages from obese Zucker rats: effect of habitual exercise.
Referencia: Martín-Cordero L, García JJ, Ortega E. Noradrenaline-mediated inhibition of inflammatory cytokines is altered in macrophages from obese Zucker rats: effect of habitual exercise. Endocr Metab Immune Disord Drug Targets. 2013 Sep;13(3):234-9.
Comparative effectiveness of switching to alternative tumour necrosis factor (TNF) antagonists versus switching to rituximab inpatients with rheumatoid arthritis who failed previous TNF antagonists: the MIRAR Study.
Referencia: Gomez-Reino JJ, Maneiro JR, Ruiz J, Roselló R, Sanmarti R, Romero AB; MIRAR Study Group. Comparative effectiveness of switching to alternative tumour necrosis factor (TNF) antagonists versus switching to rituximab in patients with rheumatoid arthritis who failed previous TNF antagonists: the MIRAR Study. Ann Rheum Dis. 2012 Nov;71(11):1861-4.
Effectiveness of a clinical practice intervention in early rheumatoid arthritis.
Referencia: Descalzo MÁ, Carbonell J, González-Álvaro I, Sanmartí R, Balsa A, Hernandez- Barrera V, Román-Ivorra JA, Ivorra-Cortés J, Lisbona P, Alperi M, Jiménez-Garcia R, Carmona L; SERAP and PROAR Study Groups. Effectiveness of a clinical practice intervention in early rheumatoid arthritis. Arthritis Care Res (Hoboken). 2012 Mar;64(3):321-30.
Personality changes in bulimia nervosa after a cognitive behaviour therapy.
Referencia: Agüera Z, Krug I, Sánchez I, Granero R, Penelo E, Peñas-Lledó E, Jiménez- Murcia S, Menchón JM, Fernández-Aranda F. Personality changes in bulimia nervosa after a cognitive behaviour therapy. Eur Eat Disord Rev. 2012 Sep;20(5):379-85.
Pharmacological compliance in the treatment of arterial hypertension. A review of studies published between 1975 and 2011.
Referencia: Espinosa García J, Martell Claros N, Llerena Ruiz A, Fernández Bergés Gurrea D. Cumplimiento farmacológico en el tratamiento de la hipertensión arterial. Revisión de los estudios publicados entre los años 1975 y 2011 [Pharmacological compliance in the treatment of arterial hypertension. A review of studies published between 1975 and 2011]. Semergen. 2012 Jul-Aug;38(5):292-300.
Eating disorder symptoms and CYP2D6 variation in cuban healthy females: A report from the Ibero-American network of pharmacogenetics.
Referencia: Peñas-Lledó EM, Gonzalez I, Dorado P, Calzadilla LR, Perez B, Alvarez M, Naranjo MEG, Llerena A, CEIBA.FP Consortium of the Ibero-American network of pharmacogenetics and pharmacogenomics RIBEF. Eating disorder symptoms and CYP2D6 variation in cuban healthy females: A report from the Ibero-American network of pharmacogenetics. Current Pharmacogenomics and Personalized Medicine. 2012; 10(4):288-292
Strengths and weaknesses of pharmacogenetic studies of antipsychotic drugs: the potential value of the PEPs study.
Referencia: Mas S, Llerena A, Saíz J, Bernardo M, Lafuente A. Strengths and weaknesses of pharmacogenetic studies of antipsychotic drugs: the potential value of the PEPs study. Pharmacogenomics. 2012 Nov;13(15):1773-82.
Losartan hydroxylation phenotype in an Ecuadorian population: influence of CYP2C9 genetic polymorphism, habits and gender.
Referencia: Dorado P, Beltrán LJ, Machín E, Peñas-Lledó EM, Terán E, Llerena A; CEIBA.FP Consortium of the Ibero American Network of Pharmacogenetics and Pharmacogenomics RIBEF. Losartan hydroxylation phenotype in an Ecuadorian population: influence of CYP2C9 genetic polymorphism, habits and gender. Pharmacogenomics. 2012 Nov;13(15):1711-7.
Development of a new HPLC method for the determination of losartan urinary metabolic ratio to be used for the determination of CYP2C9 hidroxylation phenotypes.
Referencia: Dorado P, Machín E, de Andrés F, Naranjo ME, Peñas-Lledó EM, Llerena A; CEIBA.FP Consortium for the Ibero-American Network of Pharmacogenomics RIBEF. Development of a HPLC method for the determination of losartan urinary metabolic ratio to be used for the determination of CYP2C9 hydroxylation phenotypes. Drug Metabol Drug Interact. 2012;27(4):217-33.
High- performance liquid chromatography method using ultraviolet detection for the quantification of aripiprazole and dehydroaripiprazole in psychiatric patients
Referencia: Dorado P, de Andrés F, Naranjo ME, Peñas-Lledó EM, González I, González AP, de la Rubia A, Llerena A. High-performance liquid chromatography method using ultraviolet detection for the quantification of aripiprazole and dehydroaripiprazole in psychiatric patients. Drug Metabol Drug Interact. 2012;27(3):165-70.
Pharmacogenetics in Latin American populations: regulatory aspects, application to herbal medicine, cardiovascular and psychiatric disorders.
Referencia: Rodeiro I, Remírez-Figueredo D, García-Mesa M, Dorado P, LLerena A; CEIBA.FP Consortium of the Ibero American Network of Pharmacogenetics and Pharmacogenomics RIBEF. Pharmacogenetics in Latin American populations: regulatory aspects, application to herbal medicine, cardiovascular and psychiatric disorders. Drug Metabol Drug Interact. 2012;27(1):57-60.
Referencia: Peñas-Lledó EM, Blasco-Fontecilla H, Dorado P, Vaquero-Lorenzo C, Baca-García E, Llerena A. CYP2D6 and the severity of suicide attempts. Pharmacogenomics. 2012 Jan;13(2):179-84.
CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population.
Referencia: Dorado P, Heras N, Machín E, Hernández F, Teran E, Llerena A. CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population. Eur J Clin Pharmacol. 2012 May;68(5):637-44.
CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans.
Referencia: Llerena A, Dorado P, Ramírez R, González I, Alvarez M, Peñas-Lledó EM, Pérez B, Calzadilla LR. CYP2D6 genotype and debrisoquine hydroxylation phenotype in Cubans and Nicaraguans. Pharmacogenomics J. 2012 Apr;12(2):176-83.
Pasteurella canis peritonitis in a peritoneal dialysis patient.
Referencia: Castellano I, Marín JP, Gallego S, Mora M, Rangel G, Suarez MA, Deira JL, Garcia-Bernalt V, Novillo R, Gómez-Martino JR. Pasteurella canis peritonitis in a peritoneal dialysis patient. Perit Dial Int. 2011 Jul Aug;31(4):503-4.
Varicella zoster virus: complications in an ANCA-positive vasculitis.
Referencia: Suárez Santisteban MA, García-Bernalt Funes MV, Mora Mora M, Novillo Santano RA, Rangel Hidalgo G, Cebrián C. Varicella zoster virus: complications in an ANCA-positive vasculitis. Nefrologia. 2011;31(5):616-8.
ATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: a case control study.
Referencia: Almoguera B, Riveiro-Alvarez R, Lopez-Castroman J, Dorado P, Lopez-Rodriguez R, Fernandez-Navarro P, Baca-García E, Fernandez-Piqueras J, Dal-Ré R, Abad- Santos F, Llerena A, Ayuso C; Spanish Consortium of Pharmacogenetics Research in Schizophrenia. ATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: a case control study. BMC Med Genet. 2011 Jun 9;12:81.
Pharmacogenomics and personalized medicine in clinical practice.
Referencia: Manolopoulos VG, Dechairo B, Huriez A, Kühn A, Llerena A, van Schaik RH, Yeo KT, Ragia G, Siest G. Pharmacogenomics and personalized medicine in clinical practice. Pharmacogenomics. 2011 May;12(5):597-610.
Pharmacogenetics of the antiepileptic drugs phenytoin and lamotrigine.
Referencia: López M, Dorado P, Monroy N, Alonso ME, Jung-Cook H, Machín E, Peñas-Lledó E, Llerena A. Pharmacogenetics of the antiepileptic drugs phenytoin and lamotrigine. Drug Metabol Drug Interact. 2011;26(1):5-12.
Relevance of CYP2D6 for risperidone pharmacokinetics, pharmacodynamics and adverse reactions.
Referencia: Llerena A, Dorado P, Peñas-Lledó EM. Relevance of CYP2D6 for risperidone pharmacokinetics, pharmacodynamics and adverse reactions. Pharmacogenomics. 2011 Mar;12(3):311-3.
High risk of lifetime history of suicide attempts among CYP2D6 polymorphism in patients with eating disorders.
Referencia: Peñas-Lledó EM, Dorado P, Agüera Z, Gratacós M, Estivill X, Fernández-Aranda F, Llerena A. High risk of lifetime history of suicide attempts among CYP2D6 ultrarapid metabolizers with eating disorders. Mol Psychiatry. 2011 Jul;16(7):691-2.
CYP2C9 allele frequency differences between populations of Mexican-Tepehuano, and Spaniards.
Referencia: Dorado P, Sosa-Macias MG, Peñas-Lledó EM, Alanis-Bañuelos RE, Wong ML, Licinio J, Lares Asseff I, Llerena A. CYP2C9 allele frequency differences between populations of Mexican Mestizo, Mexican-Tepehuano, and Spaniards. Pharmacogenomics J. 2011 Apr;11(2):108-12.
Specific eating disorder clusters based on social anxiety and novelty seeking.
Referencia: Peñas-Lledó E, Jiménez-Murcia S, Granero R, Penelo E, Agüera Z, Alvarez-Moya E, Fernández Aranda F. Specific eating disorder clusters based on social anxiety and novelty seeking. J Anxiety Disord. 2010 Oct;24(7):767-73.
Influence of CYP2D6 deletion, multiplication, -1584C-->G, 31G-->A and 2988G-->a gene polymorphisms on dextromethorphan metabolism among mexican tepehuanos and mestizos.
Referencia: Sosa-Macías M, Dorado P, Alanis-Bañuelos RE, Llerena A, Lares-Asseff I. Influence of CYP2D6 deletion, multiplication, -1584C-->G, 31G-->A and 2988G-→a gene polymorphisms on dextromethorphan metabolism among Mexican tepehuanos and mestizos. Pharmacology. 2010;86(1):30-6.
[The current situation for vascular access in the province of Caceres].
Referencia: Castellano Cerviño I, Gallego Domínguez S, Suárez Santisteban MA, González Castillo PM, Gad N. Situación actual del acceso vascular en la provincia de Cáceres [The current situation for vascular access in the province of Caceres]. Nefrologia. 2009;29(2):178-80.
[Results of applying the Scientific Technical Quality Programme and Constant Quality Improvement for peritoneal dialysis].
Referencia: Castellano Cerviño I, Gallego Domínguez S, Gad N, Suárez Santisteban M, Gómez-Martino Arroyo JR, Martín Mejías I, Domínguez de la Calle A. Resultados de la aplicación del plan de calidad científico-técnica y de mejora continua de calidad en diálisis peritoneal [Results of applying the Scientific Technical Quality Programme and Constant Quality Improvement for peritoneal dialysis]. Nefrologia. 2009;29(3):256-62.
Economic burden of knee and hip osteoarthritis in Spain.
Referencia: Loza E, Lopez-Gomez JM, Abasolo L, Maese J, Carmona L, Batlle-Gualda E; Artrocad Study Group. Economic burden of knee and hip osteoarthritis in Spain. Arthritis Rheum. 2009 Feb 15;61(2):158-65.
Subtyping eating disordered patients along drive for thinness and depression.
Referencia: Peñas-Lledó E, Fernández-Aranda F, Jiménez-Murcia S, Granero R, Penelo E, Soto A, Gunnard K, Menchón JM. Subtyping eating disordered patients along drive for thinness and depression. Behav Res Ther. 2009 Jun;47(6):513-9.
Predictors of early change in bulimia nervosa after a brief psychoeducational therapy.
Referencia: Fernàndez-Aranda F, Álvarez-Moya EM, Martínez-Viana C, Sànchez I, Granero R, Penelo E, Forcano L, Peñas-Lledó E. Predictors of early change in bulimia nervosa after a brief psychoeducational therapy. Appetite. 2009 Jun;52(3):805-808.
Relevance of CYP2D6-1584>G polymorphism for thioridazine/mesoridazine plasma concentration ratio in psychiatric patients.
Referencia: Dorado P, Peñas-LLedó EM, de la Rubia A, LLerena A. Relevance of CYP2D6-1584C>G polymorphism for thioridazine:mesoridazine plasma concentration ratio in psychiatric patients. Pharmacogenomics. 2009 Jul;10(7):1083-9.
Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis.
Referencia: Sánchez-Romero MA, Dorado P, Guarino E, Llerena A. Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting- curve analysis. Pharmacogenomics. 2009 Jun;10(6):989-95.
CYP2D6 genotyping for psychiatric patients treated with risperidone: considerations for cost-effectiveness studies.
Referencia: Rodríguez-Antona C, Gurwitz D, de Leon J, Llerena A, Kirchheiner J, de Mesa EG, Ibarreta D. CYP2D6 genotyping for psychiatric patients treated with risperidone: considerations for cost-effectiveness studies. Pharmacogenomics. 2009 Apr;10(4):685-99.
Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity.
Referencia: Llerena A, Dorado P, Peñas-Lledó EM. Pharmacogenetics of debrisoquine and its use as a marker for CYP2D6 hydroxylation capacity. Pharmacogenomics. 2009 Jan;10(1):17-28.
[Telemedicine applied to Nephrology. Another form of consultation].
Referencia: Gómez-Martino JR, Suárez MA, Gallego SD, González PM, Covarsí AR, Castellano IC, Novillo RS, Deira JL, Marigliano NC, Giménez JJ. Telemedicina aplicada a la nefrología. Otra forma de consulta [Telemedicine applied to Nephrology. Another form of consultation]. Nefrologia. 2008;28(4):407-12.
[Is it time to apply the new information and communication technologies to Nephrology?].
Referencia: Gómez-Martino JR, Suárez MA, Gallego SD, Castellano IC, Covarsí AR. Es el momento de aplicar las nuevas tecnologías de la información y comunicación a la Nefrología? [Is it time to apply the new information and communication technologies to Nephrology?]. Nefrologia. 2008;28(4):365-8.
[Hypertension high resolution consultation. A year of experience].
Referencia: Covarsí A, González P, Barrera A, Suárez MA, Gallego S, Castellano I. Consulta de alta resolución (CAR) de HTA: experiencia de un año [Hypertension high resolution consultation. A year of experience]. Nefrologia. 2008;28(2):193-7.
Referencia: Castellano I, González Castillo PM, Covarsí A, Martínez Sánchez J, Suárez Santisteban MA, Gallego S, Marigliano N. Dosificación de vancomicina en pacientes en hemodiálisis [Vancomycin dosing in hemodialysis patients]. Nefrologia. 2008;28(6):607-12.
Validity, reproducibility, and responsiveness of a twelve-joint simplified power doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis.
Referencia: Naredo E, Rodríguez M, Campos C, Rodríguez-Heredia JM, Medina JA, Giner E, Martínez O, Toyos FJ, Ruíz T, Ros I, Pujol M, Miquel X, García L, Aznar JJ, Chamizo E, Páez M, Morales P, Rueda A, Tuneu R, Corominas H, de Agustín JJ, Moragues C, Mínguez D, Willisch A, González-Cruz I, Aragón A, Iglesias G, Armas C, Pablo Valdazo J, Vargas C, Calvo-Alén J, Juan-Mas A, Salvador G, Puigdollers A, Galíndez E, Garrido N, Salaberri J, Raya E, Salles M, Díaz C, Cuadra JL, Garrido J; Ultrasound Group of The Spanish Society of Rheumatology. Validity, reproducibility, and responsiveness of a twelve-joint simplified power doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis. Arthritis Rheum. 2008 Apr 15;59(4):515-22.
Inadequate iodine nutrition of pregnant women from Extremadura (Spain).
Referencia: Sánchez-Vega J, del Rey FE, Fariñas-Seijas H, de Escobar GM. Inadequate iodine nutrition of pregnant women from Extremadura (Spain). Eur J Endocrinol. 2008 Oct;159(4):439-45.
Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers.
Referencia: González I, Peñas-Lledó EM, Pérez B, Dorado P, Alvarez M, LLerena A. Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers. Pharmacogenomics. 2008 Jul;9(7):833 40.
Subtyping undergraduate women along dietary restraint and negative affect.
Referencia: Peñas-Lledó EM, Loeb KL, Puerto R, Hildebrandt TB, Llerena A. Subtyping undergraduate women along dietary restraint and negative affect. Appetite. 2008 Nov;51(3):727-30.
Aripiprazole-induced Parkinsonism and its association with dopamine and serotonin receptor polymorphisms.
Referencia: López-Torres E, Salomón J, Vicario F, Peñas-Lledó E, Dorado P, Llerena A. Aripiprazole-induced parkinsonism and its association with dopamine and serotonin receptor polymorphisms. J Clin Psychopharmacol. 2008 Jun;28(3):352-3.
Ibero-American Program of Science and Technology for Development Program.
Referencia: Wanden-Berthe C, Dos Reis MG, Llerena A, de Camino R, Miguel LJ. La tertulia del Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo [Ibero- American Program of Science and Technology for Development]. Rev Panam Salud Publica. 2008 Mar;23(3):218-9.
High risk of polydipsia and water intoxication in schizophrenia patients.
Referencia: González I, Pérez N, Peñas-LLedó EM, LLerena A, González I, de la Rubia A.High risk of polydipsia and water intoxication in schizophrenia patients. Schizophr Res. 2008 Feb;99(1-3):377-8.
Increased use of second generation antipsychotic drugs in primary care: potencial relevance for hospitalizations in schizophrenia patients.
Referencia: Cáceres MC, Peñas-Lledó EM, de la Rubia A, Llerena A. Increased use of second generation antipsychotic drugs in primary care: potential relevance for hospitalizations in schizophrenia patients. Eur J Clin Pharmacol. 2008 Jan;64(1):73-6.
Anterior cingulate activity in bulimia nervosa: a fMRI case study.
Referencia: Peñas-Lledó EM, Loeb KL, Martin L, Fan J. Anterior cingulate activity in bulimia nervosa: a fMRI case study. Eat Weight Disord. 2007 Dec;12(4):e78-82.
Pharmacogenomics at the crossroads: what else than good science will be needed for the field to become part of Personalized Medicine?
Referencia: Llerena A, Michel G, Jeannesson E, Wong S, Manolopoulos VG, Hockett RD, Boubekeur K, Siest G, Beaune P, Haefliger C, Arnold HP, Junien C, Petrovic N, Molloy R, Bekers O, Donnelly C, Arens HJ, Kaput J, McComb J. Third Santorini conference pharmacogenomics workshop report: "Pharmacogenomics at the crossroads: what else than good science will be needed for the field to become part of Personalized Medicine?". Clin Chem Lab Med. 2007;45(7):843-50.
Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele.
Referencia: Dorado P, Peñas-Lledó EM, González AP, Cáceres MC, Cobaleda J, Llerena A. Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele. Fundam Clin Pharmacol. 2007 Aug;21(4):451-3.
Association between T102 and A-1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs
Referencia: Peñas-Lledó EM, Dorado P, Cáceres MC, de la Rubia A, Llerena A. Association between T102C and A 1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs. Clin Chem Lab Med. 2007;45(7):835-8.
Low frequency of CYP2D6 poor metabolizers among schizophrenia patients.
Referencia: Llerena A, Dorado P, Peñas-Lledó EM, Cáceres MC, De la Rubia A. Low frequency of CYP2D6 poor metabolizers among schizophrenia patients. Pharmacogenomics J. 2007 Dec;7(6):408-10.
Estudio farmacogenético del polimorfismo metabólico de debrisoquina (CYP2D6) en la población cubana en relación a la española. [Study of debrisoquine hydroxilation polymorphism (CYP2D6) in the Cuban population compared to Spaniards].
Referencia: González I, Pérez B, Alvarez M, Dorado P, Llerena A. Estudio farmacogenético del polimorfismo metabólico de la debrisoquina (CYP2D6) en la población cubana en relación con la española [Study of debrisoquine hydroxylation polymorphism (CYP2D6) in the Cuban population compared to Spaniards]. Med Clin (Barc). 2007 May 26;128(20):772-4.
No effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patient.
Referencia: Dorado P, Berecz R, Peñas-Lledó EM, de la Rubia A, Llerena A. No effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patients. Eur J Clin Pharmacol. 2007 May;63(5):527-8.
Antipsychotic drugs and QTc prolongation: the potential role of CYP2D6 genetic polymorphism.
Referencia: Dorado P, Berecz R, Peñas-Lledó EM, Llerena A. Antipsychotic drugs and Qtc prolongation: the potential role of CYP2D6 genetic polymorphism. Expert Opin Drug Metab Toxicol. 2007 Feb;3(1):9-19.