Adenosquamous cancer of the pancreas: A multicenter retrospective studyJ. M. Ramia-Ángel · I. Jaén-Torrejimeno · A. Serrablo-Requejo · G. P. Rodríguez-Laiz · D. López-Guerra · T. Abadía-Forcén · C. Alenda · M. Serradilla-Martín · G. Blanco-FernándezAntioxidants , 11(7), 2022
AbstractIntroduction: Adenosquamous cancer of the pancreas (ASCP) is an aggressive, infrequent subtype of pancreatic cancer that combines a glandular and squamous component and is associated with poor survival. Methods: Multicenter retrospective observational study carried out at three Spanish hospitals. The study period was: January 2010–August 2020. A descriptive analysis of the data was performed, as well as an analysis of global and disease-free survival using the Kaplan–Meier statistic. Results: Of a total of 668 pancreatic cancers treated surgically, twelve were ASCP (1.8%). Patient mean age was 69.2 ± 7.4 years. Male/female ratio was 1:1. The main symptom was jaundice (seven patients). Correct preoperative diagnosis was obtained in only two patients. Nine pancreatoduodenectomies and three distal pancreatosplenectomies were performed. 25% had major complications. Mean tumor size was 48.6 ± 19.4 mm. Nine patients received adjuvant chemotherapy. Median survival time was 5.9 months, and median disease-free survival was 4.6 months. 90% of patients presented recurrence. Ten of the twelve patients in the study (83.3%) died, with disease progression being the cause in eight. Of the two surviving patients, one is disease-free and the other has liver metastases. Conclusion: ASCP is a very rare pancreatic tumor with aggressive behavior. It is rarely diagnosed preoperatively. The best treatment, if feasible, is surgery followed by the standard chemotherapy regimens for pancreatic adenocarcinoma.
Loss of KEAP1 Causes an Accumulation of Nondegradative OrganellesE. Uribe-Carretero · G. Martínez-Chacón · S. M. S. Yakhine-Diop · G,. Duque-González · M. Rodríguez-Arribas · E. Alegre-Cortés · M. Paredes-Barquero · S. Canales-Cortés · E. Pizarro-Estrella · A. Cuadrado · R. A. González-Polo · J. M. Fuentes · M. Niso-SantanoAntioxidants , 11(7), 2022
Heterogeneity of management practices surrounding operable gallbladder cancer – results of the OMEGA-S international HPB surgical surveyA. Balakrishnan · A. Jah · M. Lesurtel · B. Andersson · P. Gibbs · S. Harper · E. Huguet · V. Kosmoliaptsis · S. Liau · R. Praseedom · J. Ramia · A. Branes · J. Lendoire · S. Maithel · A. SerrabloHPB, 2022